31 results
The primary objective of the current study is to assess the efficacy of qHPV vaccination in preventing recurrence of high-grade AIN in HIV+ MSM with CD4 counts >350 x 10E6/l who were successfully treated for high-grade intra-anal AIN in the…
To determine a suitable co-trimoxazole regimen for testing in a future larger clinical trial to determine the efficacy of antibiotic prophylaxis in patients with a temporary urinary tract catheter.
The purpose of this study is to determine whether it is useful to decolonize patients undergoing primary hip or knee replacement surgery from the S. aureus skin bacteria.
• To determine the pharmacokinetics of posaconazole (new solid oral and IV) given as prophylaxis to patients who are at risk for developing fungal infections after receiving conditioning therapy (except strictly non myeloablative (NMA)) for…
The aim of this study is to evaluate if IV albumin administration improves short-term survival in patients with advanced cirrhosis (serum creatinine * 1.2 mg/dl, serum sodium * 130 mEq/l and/or serum bilirubin *4 mg/dl), signs of systemic…
Primary:To determine trends in vaccine- and nonvaccine-serotype S. pneumoniae asymptomatic colonisation in healthy 11-month-old and 24-month-old infants who have been immunized according to the Dutch NIP with 7-valent pneumococcal conjugate vaccine…
To protect children with hiv and children using immune-suppressive medication against hepatitis A and B, and to determine the immunogenicity of the combined hepatitis A and B vaccine in these children.
The main purpose of this study is to determine the appropriate age (10, 12 or 15 years) for a second MenC conjugate (MenCC) vaccine immunization in Dutch children that received a primary MenCC vaccination at a young age. A conclusion will be based…
To determine the efficacy of antibiotic prophylaxis after a tick bite in the Dutch setting, in relation to tick infection, tick engorgement and attachment time.
The purpose of the study is to test whether a centre-wide policy of incremental antibiotic therapy will reduce arrhythmia device infection in patients undergoing arrhythmia device procedures compared to a policy of conventional antibiotic…
Determine asymptomatic nasopharyngeal pneumococcal carriage and serotype distribution in elderly aged 65-70 years, 71-80 years ald 80 years and older. Assessment of the value of PCR compared with conventional culture methods.
How long does B-cell memory persist after a single conjugate MenC vaccination and which cells are involved? How is this related to the age of first vaccination? And how to define correlates of protection for immunity and memory after MenC conjugate…
The objective of the study is to evaluate the general safety of ZOSTAVAX* in subjects >=60 years of age.
The aim of this study is to investigate the immune response to a tetravalent MenACWY-TT vaccine in 10-, 12- and 15-year old children primed with the monovalent MenC-TT conjugate vaccine at a young age and to1. determine whether the MenC-specific…
Primary objective: To reduce clinically relevant respiratory tract infections (including COVID-19) ind community dwelling older persons during the pandemic of SARS-CoV-2. Secondary objective: To reduce disease severity, the duration of hospital…
The aim of this multicenter open-label, randomized controlled trial is to investigate the superiority of 5 days (extended) versus a single dose of cefazolin prophylaxis in revision arthroplasty of the hip and knee.
The main objective of this study is to determine differences in vaccine responses in the pre-elderly age group (50-65 years of age) to a primary immunization with vaccine antigens to which no or (very) low pre-vaccination antibody levels and memory…
The aim of this study is to demonstrate that a single dose of rabies vaccine can induce an equally rapid and adequate anamnestic antibody response as 2-dose PrEP to revaccination six months later.
Our primary objective is to evaluate the effect of an enhanced perioperative care program added on to usual care on the incidence of SSI. Secondary objectives are to evaluate SSI rate at 3 months follow-up, assessment of health and disability with…
The main purpose of this study is to assess the long-term antibody responses and cellular memory immunity against B. pertussis in a cohort of Dutch children, 8-9 years of age, who have been vaccinated with aP in the first year of life. Furthermore,…