19 results
Primary Objective:Pilot study: Selection of the titanium derivatives which are capable of penetrating the skin, and thus can be used in the full study as patch test materials.Full study: To compare the results of three different diagnostic tests…
To investigate the changes in facial- and hand analysis in patients with acromegaly as a result of medical treatment and pituitary surgery, and to investigate the changes in relational proportions between facial- and hand structures, incidence and…
1. The objective of this study is to aquire knowledge about the development of reactive hyperaemia and inflammatory responses of the skin after shear- force and pressure loading. We want to investigate if patients with diabetes type 2 will develop…
To determine long-term scar quality in patients admitted to a Dutch burn centre with burn wound of indeterminate depth.
Examine in vivo muscle energy metabolism in patients with burns, during rest, (prolonged) exercise and recovery.
The objective of this studie is to gather knowledge about cytokine concentrations (IL-1 *) in the skin of healthy volunteers after the application of shear- force. We want to use this knowledge in the future to investigate if different prophylactic…
Construction of a biobank of peripheral blood and skin biopsies from patients with SLE, to evaluate gene polymorphisms, gene expression profiles, new antigens and/or antibodies and to store material for analysis in future in case of newly discovered…
To test the feasibility of an intended large scale fragrance-allergy prevalence study in the population of the north of the Netherlands and to make a more reliable estimate of the prevalence in the population for poweranalysis of the intended large…
We hypothesized that one of the key mechanisms explaining the differences in effect between adalumimab and etanercept on psoriatic skin is that adalumimab, by being a monoclonal antibody like infliximab, is a better inducer of apoptosis resulting in…
To elucidate the molecular basis of skin disease.
MelanoScan
The main objective of this study is to compare calcification promoting and inhibiting factors and their interactions in the serum of PXE patients and healthy controls. Secondary objectives (optional) are:1) to identify differences in cognitive…
The overall aim of the study is to improve our understanding of the role of T cells and ILCs in cutaneous GvHD, to lay the foundation for the development of better therapies to treat cutaneous GvHD.1. T cells in GvHDThe dominant cell population in…
To investigate the difference in number, phenotype and function of plasmacytoid dendritic cells and T cells in and between patients with SSc, LS and EF and between patients with these diseases and healthy controls / patients with psoriasis.
Primary Objective: To determine the monitoring and quantificational use of RCM in patients with rosacea using topical Ivermectin.Secondary Objective(s): 1. To correlate the in vivo skin changes, identified by RCM, to the clinical assessment.2. To…
Primary: To identify potential diagnostic cytokine profiles for an allergic reaction towards a dental device in patients with symptoms of oral metal allergy. Which might lead to a better understanding of allergic based systemic reaction of oral…
The aim of this study is to measure the lymphflow in the superficial lymphvessels in the dorsal forearm in patients with no history of lymphedema. In order to further study lymphedema and to improve the technique of lymphaticovenous anastomoses, it…
pSS: • To compare the efficacy of branebrutinib with PBO at Week 24 in the treatment of subjects with pSS• To compare the safety and tolerability of branebrutinib with PBO in subjects with pSSRA: • To compare the efficacy of branebrutinib with PBO…
This study has been transitioned to CTIS with ID 2024-513534-38-00 check the CTIS register for the current data. Investigate whether treatment with azithromycin has an inhibitory effect on the mTOR pathway and/or C. acnes, causing a reduction of the…