172 results
To determine the effects of biphosphonates on radiation induced microvascular damage in the skin of breast cancer patients by comparing skin biopsies taken prior to and 4 months after treatment with a biphosphonate.
Primary Objective: To define a top set of genes that most reliably (r >=0.95) distinguish psoriasis from normal skin. We will define this set from differential methylation genes to indicate potential biomarkers.Secondary Objective(s):…
Primary Objective:Pilot study: Selection of the titanium derivatives which are capable of penetrating the skin, and thus can be used in the full study as patch test materials.Full study: To compare the results of three different diagnostic tests…
This study will investigate the effect of shear and pressure on tissue viability of human skin. Skin vitality is determined by tissue oxygenation and blood flow, measured with the 'Oxygen to See'. The focus will be on individual response…
The primary objective To assess the effectiveness of an intervention program, consisting of provision of skin care products and regular group feedback, on the skin condition in health care workers The secondary objectiveTo assess whether this…
Objective: We want to extend our understanding of the disease aetiology by performing a small pilot study that incorporates other immunologic sites involved in the disease (the skin and the microbiome) while additionally strengthening our disease…
To investigate biomarkers that play a role in the induction and resolution of AD.Secondary objective: to develop therapeutic interventions (pharmacologically) based on the revealed biomarkers.
In light of the above, our objective is to study the (cost-) effectiveness of a single intravenous gift of antibiotic prophylaxis with a firstgeneration cephalosporin prior to implant removal following surgical fixation of foot, ankle and/or lower…
The primary objective of this study is to evaluate whether the recovery of the skin barrier after acute perturbation by repetitive application of adhesive tape (*tape stripping*) is accelerated following irradiation with visible light. The secondary…
To investigate whether the upregulation of CK16 and Ki-67 (a marker for cell proliferation) in the FPSU is specific for HS, measured in inflammatory nodules and pseudo-comedones, in comparison to other dermatologic conditions that have comparable (…
Athlete*s foot is a contagious fungal infection affecting many people worldwide. This has led to the development of a self-care medical device for the treatment of athlete*s foot, which is effective, safe and easy to use in home care. Medical Brands…
1. To characterize long-term neurologic- and cognitive disorders, audiological and ophthalmological alterations in cCMV-infected children.2. To identify immunological, neurological host factors and virological factors that are predictive of…
There are indications that early laser treatment of wounds can reduce scar formation. With the laser device the wound will be heated, which is thought to be responsible for a reduced inflammatory reaction and hence for a reduced scar formation. The…
This is a pilot study with the objective of studying the effect of vaselin on TSLP expression in nonlesional human AD skin.
The objective of this study is to analyse the microbiome of the skin of patients with ichthyosis vulgaris (FLG -/-). This microbiome will be compared to the microbiome of healthy volunteers (FLG +/+) and first grade family members of patients with…
In the present study we sought to determine the levels of IL-1 cytokines in the SC and to relate them to FLG genotype, pH and the levels of filaggrin degradation products. Furthermore, we aim to investigate whether FLG genotype status relates to the…
In this study we will evaluate the effect of Sunshower Medical device at home and compare it with the effect of customary UV hardening performed in the hospital to assess whether the former is not inferior to the latter treatment. The ultimate goal…
This single-center investigation will assess the prevalence of psoriasis in a population of patients with hepatitis C and compare the prevalence in those patients receiving pegylated interferon-* therapy to those not receiving pegylated interferon…
The major aim is to apply deep sequencing technology to obtain a detailed unbiased overview of the bacterial microbiome of human skin. This will be performed in healthy individuals, psoriasis patients and atopic dermatitis patients. Furthermore, we…
Primary Objective - To determine if afamelanotide can reduce the severity of PLE related pruritis.Secondary Objectives- To determine if afamelanotide can reduce the frequency of PLE episodes;- To determine if afamelanotide can reduce the duration of…