28 results
The objective of this study is to assess whether or not apical surgery that is carried out with the help of a microscope has a higher success rate than apical surgery without the use of a microscope. No RCT is found in present literature (Del Fabbro…
The aim of this prospective study is the prevention of progression of premalignant lesions to invasive head and neck cancer by modifying the out-patient follow up and patient management.
1) Evaluating the effect and recovery of glioma surgery in eloquent areas on cognitive functioning.2) Examining the effec tof glioma surgery in eloquent areas on quality of life.3) Examining the effect of gliomas in eloquent areas on the…
Primary objectives:(1) Prevent progression of precursor lesions of the head and neck mucosa by treating selected lesions at risk for malignant outgrowth(2) Demonstrate that the detection of chromosomal instability (CIN) is indeed a powerful tool to…
Primary Objective1. Investigate the feasibility of intraoperative imaging with CBCT in open maxillectomy for verifying resection of the intended treatment volume. 2. Assess the feasibility of the intended treatment volume segmentation and resection…
Aim of studyTo investigate whether patients with disease eligible for (salvage) surgery would potentially benefit from immunotherapy, we want to study the anti-tumor reactivity of T cells that have infiltrated the tumor. Infiltration of T cells in…
To evaluate the feasibility and potential of sentinel node biopsy in patients with (recurrences of) laryngeal carcinomas and clinically negative neck undergoing total laryngectomy and neck dissection.
To evaluate the efficacy and cost-effectiveness of CBCT imaging compared to panoramic radiography prior to removal of third molars in reducing patient*s morbidity.
The primary objective of this study is to assess the diagnostic accuracy, in terms of sensitivity and negative predictive value, of preoperative CT lymphography as compared with conventional lymphoscintigraphy for SLN detection. Secondly, we aim to…
Determining the feasibility of SLN detection in the neck of oral cancer patients using a magnetic tracer (Sienna+®), MRI and hand-held magnetometer (SentiMag®).When the magnetic approach of sentinel node detection is found to be feasible, the main…
The primary objective of this feasibility study is to investigate the detection rate of SLNs using MR lymphography.
Primary Objectives: - Assess the feasibility and clinical value of 7T MR to provide a more detailed anatomic description of the anterior visual pathway in NFMA patients compared to conventional MRI. - Assess the feasibility of high-field MRI to…
The primary objectives of this study are:* Analyse if shear wave ultrasound elastography with ElastQ and LASTIC are both feasible techniques to identify differences in tongue tissue elasticity and analyse if there is a correlation between both…
Primary objective: The primary objective of this study is to compare the preoperative radiotracer kinetics (rate of injection site clearance and rate of SLN uptake) for Lymphoseek and 99mTc-Nanocoll. Secondary objectives: * To compare the number of…
The primary objective of this study is to investigate how treatment affects tissue elasticity and to what extent those effects vary in patients. The secondary objective is to link elasticity to tongue muscle strength and to functional outcome.
The next step is to personalize the model and validate the model using different modalities. These modalities are grouped into four subprojects. Finally, the results of the subprojects will be integrated within the biomechanical model so that a…
The primary objective is to clarify the frequency of t-BPPV in patients after mild TBI. Secondary objectives are: assessment of the symptoms of t-BPPV and the treatment success of t-BPPV.
This study has been transitioned to CTIS with ID 2024-514233-37-00 check the CTIS register for the current data. To evaluate the feasibility and prove the concept of sentinel node biopsy in patients with carcinoma of the parotid gland and scheduled…
We propose to use an alternative superparamagnetic tracer containing ironoxide, which can be detected with MRI and with a magnetic probe. The spatial resolution of MRI is superior to gamma camera detection. Moreover, there is no radiation exposure…
With this prospective randomized clinical trial, we aim to investigate if the use of prophylactic PMMF on the pharyngeal closure for reinforcement in TL patients under high risk for PCF because of low (SMM), can reduce the risk of PCF to a level of…