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Randomized controlled trial of controlled hand/foot cooling to prevent neuropathy and preserve quality of life in adults treated with oxaliplatin.

This randomized phase II open label study examines the effect of controlled cooling versus no cooling on the incidence and severity of oxaliplatin-induced peripheral neuropathy (OIPN) in patients treated with oxaliplatin.

Effectiveness of a guided e-health CBT-I based intervention for insomnia in autistic adults (i-Sleep Autism)

Objective: To test if participants with autism engaging in a CBT-I based online guided intervention (i-Sleep Autism) will experience a significant reduction in insomnia symptoms and improved mental health outcomes compared to the control group (…

A randomized clinical trial to study positive effects of "T-REX Twente regimen" (Thoracic surgery Rehabilitation Experts Twente) on quality of life and mobilisation activities for cardiac surgery patients after full median sternotomy, compared to usual care

Do the T-REX Twente precautions have a positive impact on the quality of life (MAcNew QLMI), level of physical activity, and reduction of fear of movement in heart patients after a total median sternotomy compared to the (current) standard…

High intensity interval training in patients with a right ventricle to pulmonary artery conduit

Primary Objective: To assess the efficacy, expressed by change in peak oxygen consumption obtained with cardiopulmonary exercise testing (CPET), of a HIIT program in patients with an RV-PA conduit.Secondary Objective(s): To determine predictors for…

Early variations of immune aging: the EVIA-NL study

The aim of this study is to characterize the immune system and its changes over time. We aim to identify the factors that influence the kinetics of immune system aging, to describe potential aging endotypes in different individuals, and correlate…

SUicidality and Needs among people Seeking EuThanasia based on psychological suffering (SUNSET)

1. To gain insights into care needs with regard to death wishes, death thoughts and suicidality of people requesting euthanasia due to psychological suffering;2. To gain insights into characteristics of death wishes, death thoughts and suicidality…

Research on the mechanism of cognitive decline in patients after cerebellar pontine angle tumour surgery

Our aim is to identify cognitive dysfunction in patients with a cerebellar pontine angle tumour (koos classification grade 4 schwannoma) that have been operated in order to prevent cognitive decline in future patients. For this purpose, we want to…

LIGHT (Lifestyle Intervention in the memory clinics of General and academic Hospitals Trial): Secondary prevention of dementia in memory clinics: implementation and (cost-) effectiveness of an integrated lifestyle intervention

The primary objectives are to examine both the (cost-)effectiveness of an innovative 1-year lifestyle intervention on lifestyle change measured by the validated Lifestyle for Brain Health Score (LIBRA) in older adults with a subjective cognitive…

Evaluating the Feasibility of a Gamified Lifestyle Change Intervention for Patients with Symptomatic Atrial Fibrillation (EHRA Class IIb or Higher): GAMES4CARE.

The primary objective of this study is to evaluate the adherence to a 3-month gamification intervention integrated with a recently developed platform for continuous lifestyle monitoring (Care-On) in patients with recurrent atrial…

Measurement of Leakage of FFP2 Respirators and Surgical Masks in Human Volunteers

Primary Objective: Assess the leakage of FFP2 respirators and surgical masks in human subjects using inhalable aerosols consisting of a solution of fluorescein in water. Secondary Objective(s): (a) Study the variability in total…

Establishing a Controlled Human Infection Model with the Chikungunya live attenuated vaccine VLA1553 in healthy volunteers

The main objective of this study is to establish a controlled human infection model for Chikungunya using the VLA1553 vaccine.Primary objectives:- To assess the infection rate induced by a single administration of the VLA1553 vaccine- To assess the…

The NUTRIOME study: Precision nutrition and postprandial immune response

To acquire metabolic health data from three dietary challenge meals for thedevelopment of an algorithm for personalised dietary advice, and subsequentlytest the effectiveness of this personalised dietary advice compared to ageneral healthy diet…

Lifestyle Self-Monitoring of Individualized Multiple Risk Factor Management towards Disease Modification of Dementia and other Age-related Diseases ;Pilot Study: DEVELOPMENT OF A PERSONALIZED MULTI COMPONENT LIFESTYLE INTERVENTION AND TESTING OF THE BAM-COG TOOL AGAINST COGNITIVE DECLINE.

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Direct procurement (DP) and hypothermic oxygenated perfusion (HOPE) of donor hearts after circulatory death (DCD) using the XVIVO Heart Assist Transport System

Primary objective:To evaluate patient survival after direct procurement and hypothermic oxygenated machine perfusion of DCD donor hearts using the XVIVO Heart Assist Transport System.Secondary objective(s):The secondary objectives are to evaluate…

ENRICHED

To compare the effect of a 6-month of enriched care consisting of additional protein intake and regular resistance exercise on the prevalence of disproportional fat-free mass loss (defined as a FFML/WL>30% as main outcome parameter) in…

A web based cognitive behavioral therapy that addresses gender
dysphoria, gender minority stress and suicidality among gender minority youth. A Randomized Control Trial

Research question:To what extent is a web-based, Cognitive Behavioral Therapy (CBT) specially designed for young gender diverse youth in the Netherlands, an effective treatment to reduce their suicidality? Are there gender, sex assigned at birth,…

Randomized, double-blind, sham-controlled trial to investigate combined occipital and supra-orbital neuromodulation in resistant migraine. The RECLAIM study.

To evaluate the safety and performance, including clinical benefit, of the PRIMUS System for the treatment of Resistant Migraine.

Exploring diabetes numeracy and health literacy across Europe - EDUCATE study

For this study, we will: - Quantify health literacy and numeracy in people with type 1 or type 2 diabetes on intensive insulin therapy (Multiple daily injections of insulin (MDI), or continuous subcutaneous insulin infusion (CSII)) - Examine the…

Feasibility of Pre-emptive VACStent Placement after Ivor Lewis Esophagectomy, to Prevent Anastomotic Leakage (PREVENT feasibility study)

We aim to evaluate the technical and logistic feasibility and safety of pre-emptive VACStent placement in patients undergoing esophagectomy with gastric conduit reconstruction, to prevent anastomotic leakage by early endoscopic vacuum therapy (EVT…

RUTI-FREEDOM: Recurrent Urinary Tract Infections in Females Receiving Effective Education, Digital Outreach & Management - a multicenter prospective randomized controlled trial in the Netherlands

A pilot study on digital coaching in rUTI at the Urology Department of Isala tested an app-based treatment additional to standard care.[8] The app provides information on rUTI aetiology, lifestyle recommendations, treatments, and the value of…