112 results
To study the feasibility and safety of permissive lung–protective ventilation in adult critically ill patients receiving invasive ventilation for acute hypoxemic respiratory failure, and to inform the design of a future randomized clinical trial in…
To gain insight in the facilitators and barriers for feedback to ED physicians about the diagnostic process
To assess the impact of short-term forearm immobilization on forearm muscle glucose uptake and amino acid net balance and kinetics of individuals with T2D compared with a control group with normoglycaemia.
Primary objective• Assess the ability of donepezil to reverse biperiden-induced effects on adaptive tracking performance at timepoint 4h Secondary objectives• Evaluate the PK of donepezil and biperiden• Investigation of pro-cholinergic effects of…
Primary objective 1: To understand how individuals with recurrent scabies symptoms experience the impact of scabies on their daily lives over time following a visit to the scabies clinic. Primary objective 2: To understand how individuals with…
The main objective of the study is to establish a controlled human infection model (CHIM) for RSV for future drug and vaccine testing and to identify the inoculation dose needed to induce RSV infection with this new strain in 50-70% of exposed…
The objectives of this pilot study are to obtain insight in: 1. healthcare visit behaviour of patients with recent onset hip or knee complaints; 2. patients’ barriers and facilitators to visit a primary healthcare professional…
The objective of this study is to pilot the feasibility of MRI and cine imaging in improving pre-operative staging of colon tumors. The specific aims of this pilot study are to establish an optimized scanning protocol and provide preliminary…
Primary objective: study the technical feasibility and safety to perform stereotactic radiotherapy on MR-linac for cT1-2 glottic cancer patients.Secondary objectives: monitor the patient safety, toxicity and tolerability of this…
To evaluate the disease course of diverticulitis in immunocompromised patients to determine a safe and effective treatment strategy.
This study aims to examine how senior year medical residents from different specialties in the Netherlands understand and apply the legal framework for reporting possible child maltreatment. Moreover, we aim to understand the threshold to report a…
[1] Mapping the demographic and clinical profile of pilots with (suspected) cardiovascular disease. [2] Investigating the role of non-invasive and invasive diagnostics within the treatment pathway of pilots with cardiovascular disease. [3]…
The aim of this study is two-fold. First, we will test a newly developed VR environment that is able to adjust to real-time physiological parameters indicative for stress such as heart rate and heart rate variability and its effects on…
Primary objective: Monitoring to evaluate the microcirculation in critically ill patients admitted to the ICU.
In a previous study, the validity of the FitMáx© in measuring physical condition was examined in comparison to the gold standard—an exertion test with breath gas analysis. The aim of the current follow-up study is to improve the international…
Primary Objective: to determine the dose effect relationship between radiation dose and liver function by comparing the change in liver function after SBRT in whole liver and liver sub-volumes receiving a low/medium/high doses of radiation.
Determine the optimal set of implementation strategies to introduce ERATS in the Netherlands; evaluate whether high protocol adherence indeed leads to the expected reduction in length of hospital stay, complications, and readmissions, alongside…
Primary ObjectiveTo assess the safety, feasibility and frequency of relapsing P. vivax PvW1 infection after experimental sporozoite-administered Controlled Human Malaria Infection (CHMI)Secondary ObjectivesTo assess the immune response to primary…
Our primary objective in this study is to predict treatment outcome for SSRI, CBT, rTMS, esketamine, and ECT in patients with MDD with the use of biomarkers and machine learning using data obtained before a new or follow-up treatment. Our secondary…
Determine the safety (oncological outcome and toxicity) of an comprehensive treatment combining recent advances in the treatment of high risk prostate cancer