39 results
Primary:To understand the relationship between novel risk markers (based on the following) and clinical outcome. Secondary:Developing a score from the predictive model that can be used to assess risk given a patient*s combination of risk factors.
Determine the frequency, phenotype and function of disorder-related immune cells, or levels of immune molecules in skin and peripheral blood of patients with inflammatory skin diseases, during the active phase of disease prior to and/or at any time…
The aim of the 100-plus Study is to identify moleculair and environmental constellations that maintain cognitive healthduring extreme aging.
To optimize (early) diagnosis and risk-stratification of (early) cardiomyopathy phenotypes and to create a better understanding of underlying pathophysiological processes.
Primary objective: 1. To identify the components in human milk (e.g. nutrients, oligosaccharides, fatty acids and (pathogen specific) immunoglobulins) that have a protective effect against respiratory tract infections during the first year of life.…
To explore the feasibility and opportunities for new imaging procedures, of relevance of Amsterdam UMC prioritized areas, that a ultra-high sensitivity total body PET-CT system can offer for improving diagnosis and dose reduction.The protocol…
Primary objectives:To prospectively assess longitudinal changes in Proteolipid Protein 1 (PLP1) and additional disease-related biomarkers in cerebral spinal fluid (CSF) and blood and evaluate their utility in support of the development of therapies…
Primary Objective:The primary objective of this study is to prospectively validate a novel intestinal ultrasound (IUS) Crohn*s disease (CD) activity index and component items, correlating CD activity and responsiveness to therapy as evaluated by IUS…
Primary Objective: to develop and evaluate a machine learning (ML) prediction model of brain injury in neonates at high-risk for CP to predict motor, behavioral, and cognitive outcome more accurately.This aim will be achieved by: developing and…
The study aims to determine the feasibility and diagnostic accuracy of quantitative Magnetic Resonance Imaging (MRI) techniques for determining the presence of portal hypertension in patients with severe liver disease. The secondary objectives are…
Primary objective:The objective of this randomized phase 2 study is to demonstrate efficacy of RE in terms of PFS in colorectal cancer patients with liver-only metastases who are candidates for palliative systemic treatment with capecitabine plus…
To determine which biological processes play an essential role in immune-pathological changes in vitiligo skin depigmentation.
The primary research objective is to assess the feasibility of fetal CMR in all academic centers in The Netherlands.The second research objective of the study is to investigate the diagnostic capacity of fetal CMR for aortic and pulmonary CHD and…
We propose to set up a bladder cancer infrastructure within the logistic framework of the NCR. Patients with HR-NMIBC, MIBC and mBC will be prospectively recruited for ProBCI with longitudinal assessments from primary diagnosis until death. Main…
The purpose of the study is to systematically document the signs and symptoms of sexual abuse in infants and very young children and the short-, medium-, and long-term effects of the abuse, including the effects of the persistence of pornographic…
Primary objective • In this study we will investigate whether biochemical imaging of change (Δ, figure 1) in the metabolic phospholipid ratios of PME and PDE between baseline and after 2 weeks of therapy are predictive for progression free survival…
The primary objective of this Clinical Performance Study is to utilize the Device for performance evaluation to detect HLA-A Locus alleles as part of the eligibility criteria for patients to receive an experimental medicinal product under the DS2243…
The primary aim of this study is to investigate whether a canal wall up (CWU) tympanomastoidectomy with obliteration of the mastoid and paratympanic or epitympanic spaces reduces cholesteatoma recurrence and residual rates compared to the same…