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A Single-Dose, Open-Label, Randomized, Replicate Crossover Pivotal Bioequivalence Study in Healthy Subjects to Assess the Bioequivalence of Darunavir 675 mg, Emtricitabine 200 mg, and Tenofovir Alafenamide 10 mg in the Presence of Cobicistat 150 mg when Administered as a Fixed Dose Combination (Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide) Compared to the Coadministration of the Separate Agents (Darunavir, Cobicistat, and Emtricitabine/Tenofovir Alafenamide), Under Fed Conditions

- To evaluate the single-dose PK and pivotal bioequivalence of 3 compounds darunavir (DRV) 675 mg, FTC 200 mg, and tenofovir alafenamide (TAF) 10 mg in the presence of cobicistat (COBI)150 mg when administered as an fixed-dose combination (FDC) (D/C…

The enrichment of the fat graft in facial fat grafting for increased volume retention

The comparison of standard fat grafting with enriched fat grafting.

Extension of the randomized, double-blind, placebo-controlled single ascending dose study to assess the safety and tolerability of AP30663 in healthy subjects.

Primary ObjectivesTo evaluate the safety and tolerability of AP30663 in healthy males at doses up to 12mg/kgExploratory ObjectiveTo evaluate the effect of AP30663 on electrocardiographical parameters.

Intra-operative visualization and treatment of salivary glands affected by sjögren*s syndrome using contrast enhanced ultrasound sialendoscopy (ceuss): a pilot study

our aim is to investigate practical applicability and safety of contrast enhanced ultrasound sialendoscopy (CEUSS) in salivary Parotid and Submandibular glands affected by Sjögren*s Syndrome

Improving respiratory monitoring by directly capturing the electrical activity of the diaphragm

To collect reference data of dEMG in neonates to use for testing the Bambi Belt B.V. algorithm which is under development.

How effective is local treatment of Molluscum Contagiosum compared to whatchful waiting?

The aim of this study is to compare the effect of early treatment on healing and quality of life with the usual expectant policy in children with mollusca contagiosa.

Clinical Observational Study into Mitochondrial Oxygenation Predicting Ominous Lactate In Trajectory around Abdominal Surgery

Primary objectives: - To test the hypothesis that a relationship between mitochondrial oxygenation and serum lactate existsSecondary objectives:- To provide data for estimating the number of patients needed for a clinical trial to prove the above…

A Single-Dose, Open-Label, Randomized, Replicate Crossover Pivotal Bioequivalence Study in Healthy Adult Participants to Assess the Bioequivalence of Darunavir 675 mg, Emtricitabine 200 mg, and Tenofovir Alafenamide 10 mg in the Presence of Cobicistat 150 mg when Administered as a Fixed Dose Combination (Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide) Compared to the Co-administration of the Separate Agents (Darunavir, Cobicistat, and Emtricitabine/Tenofovir Alafenamide), Under Fed Con

- To evaluate the single-dose PK and pivotal bioequivalence of 3 compounds darunavir (DRV) 675 mg, FTC 200 mg, and tenofovir alafenamide (TAF) 10 mg in the presence of cobicistat (COBI)150 mg when administered as an fixed-dose combination (FDC) (D/C…

An Open-label, Randomized Study in Healthy Participants to Investigate Effects of Food (high-fat) and Repeated Administration of Itraconazole on the Pharmacokinetics of JNJ-67953964.

- To assess the effect of food (high-fat) on the bioavailability and pharmacokinetic (PK)- profile of a solid dosage formulation of JNJ-67953964.- To assess the effects of repeated QD administration of 200 mg of itraconazole (steady state) on the…

Early detection of head and neck cancer relapse by expression profiling of blood platelets and/or ctDNA analysis in plasma and oral rinses

Accuracy of early detection of recurrent/metastatic disease in HNSCC patients treated for cure, and the median and range of time intervals between relapse and presence of ctDNA in plasma and oral rinses as well as TEPs.

PLEASE5+: Long-term outcomes and quality of life of patients with symptoms attributed to Lyme borreliosis

The primary objective is to assess the long-term (5-8 years) quality of life in patients who previously participated in the placebo-controlled randomized controlled trial on the effect of prolonged antibiotic treatment on persistent symptoms…

In vitro characterization of the immune response of recovered COVID-19 patients and healthy controls to SARS-CoV-2.

- To assess the in vitro memory T cell response to 20 therapeutic SARS-CoV-2 vaccine candidate synthetic long peptides (SLPs);- To assess the in vitro humoral immune response to 20 therapeutic SARS-CoV-2 vaccine candidate SLPs.

Effectiveness and cost-effectiveness of internet-based treatment for insomnia in depressed patients treated at a mental healthcare outpatient clinic.

The current project aims to assess both the effectiveness and cost-effectiveness of an internet-based insomnia intervention (i-Sleep) in addition to usual care for depression, compared to usual care alone, in depressive patients with comorbid…

Repeated exposure to sweet and sweet-sour drinks: do sweet taste preferences change in toddlers?

The aim of this study is to investigate the influence of repeated exposure to sweet and sweet-sour apple juices on sweet taste preferences of 2.5-3 years old children.

Identifying disease specific pathways and modifiers in Phospholamban r14del cardiomyopathy

Our main objective is to identify disease modifiers in PLN r14del cardiomyopathy by studying patients are different ends of the PLN r14del cardiomyopathy disease spectrum with respect to differences in the circulating proteome and metabolome and in…

Effect of Iodine treatment in patiënts with COVID-19 disease.

Demonstrate that iodine treatment has a beneficial effect on the course of COVID-19 disease. Beneficial effect is defined as less critically relevant deterioration such as transfers from regular to intensive care units, fewer days of hospitalization…

Early detection of Barrett's esophagus and esophageal cancer: accuracy and acceptability of a novel screening strategy in primary care.

To determine the accuracy and acceptability of a minimal-invasive screening strategy (breath testing (eNose) followed by unsedated transnasal endoscopy (uTNE)) for Barrett*s esophagus (BE) and esophageal adenocarcinoma (EAC).

Gastric emptying and digestion of whey protein gels

Primary: To investigate the effect of protein density and texture on gastric emptying of protein-rich solid food. Secondary: To investigate the use of MRI T2 and T1 of gastric content on indicating protein hydrolysis in stomach.

The value of biomarkers as diagnostic tool in Obstructive Sleep Apnea

To identify biomarkers associated with OSA and OSA disease severity by investigating whether there are biomarkers in agreement with PSG, pre- and post-treatment and does OSA treatment result in improvement of these markers associated with…

A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Nemolizumab (CD14152) in Subjects with Moderate-to-Severe Atopic Dermatitis

Primary objective: The primary objective is to assess the efficacy and safety of nemolizumab (CD14152) after a 16-week treatment period in adult and adolescent subjects with moderate-to-severe atopic dermatitis (AD) not adequately controlled with…