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Clinical and cost-effectiveness of group schema therapy for
complex eating disorders: the GST-EAT study

The aim of the current project is to test the clinical and cost-effectiveness of GST for patients with an ED (i.e., anorexia nervosa, bulimia nervosa, other specified), that are not likely to benefit from CBT-E. The study will focus on those…

First-in-human, randomized, double-blind, placebo-controlled, single ascending dose study to evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic effects of Apta-1.

Part ATo evaluate the safety and tolerability of single and split intravenous doses of Apta-1 in healthy volunteers.Part BTo evaluate the safety and tolerability of split intravenous doses of Apta-1 after LPS infusion in healthy volunteers.

Dutch ICH Surgery Trial; minimally invasive endoscopy-guided surgery for spontaneous intracerebral hemorrhage

1. To study whether minimally invasive endoscopy-guided surgery, in addition to standard medical management, for the treatment of spontaneous supratentorial ICH performed within 8 hours of symptom onset, improves functional outcome in comparison…

A randomized, double-blind, placebo-controlled, Phase III trial to
evaluate the efficacy and safety of intra-articular injections of
RTX-GRT7039 in adult subjects with pain associated with osteoarthritis of the knee

Primary objective:Demonstrate the analgesic efficacy of intra-articular RTX-GRT7039 compared with placebo.Secondary objective:• Demonstrate the analgesic efficacy of intra-articular RTX-GRT7039 compared with placebo.• Demonstrate the efficacy of…

EffectiveNess of a multimodal preHAbilitation program in patieNts with bladder canCEr undergoing cystectomy. The ENHANCE randomized controlled trial.

To study the effectiveness of a multimodal prehabilitation program preceding radical cystectomy in reducing the number and severity of perioperative complications within 90 days, shortening the length of hospitalization and reducing the number of…

A randomized, placebo-controlled, double-blind, parallel-group Phase 2a exploratory study with placebo run-in to investigate PK/PD effects, safety, tolerability and pharmacokinetics of REM0046127 oral suspension compared with placebo in subjects with mild to moderate Alzheimer's disease

• To assess the tolerability and safety of the investigational medicinal product

A First-in-Human, Double-Blind, Randomised, Vehicle-Controlled Phase I/II Proof of Concept Study to Investigate the Safety, Tolerability, Pharmacokinetics and Efficacy of BEN2293 in Patients with Mild to Moderate Atopic Dermatitis.

PrimaryThe primary objective of this study is to assess the safety and tolerability of BEN2293, administered as multiple topical doses to increasing body surface area (BSA), in patients with mild to moderate AD.SecondaryPharmacokinetics· To…

Electrophysiological markers of cortical excitability to predict response to treatment with anti-seizure medication

To address the potential of cortical excitability measures using TMS-EEG/EMG to differentiate between responders and non-responders to ASM in people with refractory focal epilepsy. The secondary objectives are to validate visual evoked potentials (…

Alternative dosing scheme of pomalidomide 4 mg every other day versus pomalidomide 2 mg and 4 mg every day: reduction in costs, same efficacy? A PKPD bioequivalence pilot study - the POMAlternative study

Primary objectiveTo assess in which percentage of patients the AUC/MIC ratio is above the target of 270 µg*h/L and Ctrough is above the target EC50 (2.7 µg/L) during usage of pomalidomide 4 mg every day, pomalidomide 4mg every other day, and…

An explorative and experimental study to assess the feasibility, acceptability and effectiveness of four imagery intervention techniques in the treatment of auditory vocal hallucinations

The main objective of this study is to assess the feasibility, acceptability, and effectiveness of four imagery intervention techniques adapted from the protocol of Holmes (2019) for auditory vocal hallucinations. We are primarily interested in…

A randomized, double-blind, placebo-controlled, parallel-group, phase 2 study to evaluate the safety and efficacy of CT1812 in subjects with mild to moderate Alzheimer's disease

The purpose of this study is to evaluate the safety and efficacy of two doses of the study drug CT1812 per day for six months in subjects with mild to moderate Alzheimer's disease. CT1812 will be compared with a placebo. A placebo is a product…

A multicenter, open-label extension study to investigate the long-term safety of FAB122 in patients with Amyotrophic Lateral Sclerosis.

To evaluate the long-term safety of FAB122 in patients with ALS.

A Randomized, Double-blind, Placebo-controlled, Single Ascending Dose and Multiple Ascending Dose Study to Investigate the Safety, Tolerability, and Pharmacokinetics of REC-3964 in Healthy Subjects

REC-3964 is a new investigational drug, meaning that it has not yet been approved or marketed in the Netherlands or anywhere else at this time.In this study, REC-3964 is investigated in humans for the first time. REC-3964 has not been used by humans…

The influence of electroencephalographic density spectral array guidance of sevoflurane administration on recovery from general anaesthesia in children between 6 months and 12 years.

To evaluate the influence of DSA monitoring, provided by the NarcotrendTM monitor, on the speed of emergence and recovery from GA.