18 results
To assess sorafenib pharmacokinetics and biodistribution, K-Ras mutational status, tumor uptake and tumor response in NSCLC patients.
1) To determine clinical safety and tolerability of local i.d. administration of a single dose of tremelimumab in clinical stage II melanoma patients scheduled to undergo a SLN procedure. 2) To ascertain the immunological effects of local i.d.…
Primary Objective: 1. To determine if and in what way the pelvic organ prolapse influences the sexual function and the self-image of the patient2. To compare the POP group and the control group on level of sexual function and (sexual) self-concept…
This study has been transitioned to CTIS with ID 2025-520915-14-00 check the CTIS register for the current data. Primary objectiveTo investigate the client*s satisfaction over time for the treatment of glabellar frown lines (GFL), horizontal…
This pilot study aims to explore whether and why the cardiorespiratory fitness is compromised in newly diagnosed patients with early Relapsing Remitting Multiple Sclerosis (RRMS) with no or minimal clinical symptoms (i.e. Expanded Disability Status…
The objective of our randomized controlled trial (RCT) is to assess the effectiveness of a multimodal manual therapy treatment compared to usual care for the prophylactic treatment of migraine.
This study has been transitioned to CTIS with ID 2024-513537-21-00 check the CTIS register for the current data. To investigate the association between quantitative changes in whole body F-18-PEG Folate PET/CT (Folate PET) after 4 weeks and clinical…
This study has been transitioned to CTIS with ID 2024-516125-31-02 check the CTIS register for the current data. Primary objective is to determine safety and tolerability, dose limiting toxicities (DLTs), maximum tolerated dose (MTD) and recommended…
The overall objective of this study is to use standard clinical measures to explore the safety and effects of open-label manualized MDMA-assisted psychotherapy with a flexible dose of MDMA in participants with severe PTSD, and to serve as an…
In the present randomised double blind controlled study, we will study the effects of GOS or FOS vs a placebo on stool consistency. Other parameters to be investigated include stool frequency, stool consistency in number of cases (%), painful…
This study aims to investigate if endoscopic trans-sphenoidal prolactinoma resection as a first line treatment (PRolaCT-1), or as an equally valid second line treatment after a short (2-12 months) or long (>12 months) period of pretreatment…
The primary hypothesis of this study is that the 6-month OS rate of patients with newly diagnosed stage 3B AL amyloidosis will exceed 50% after primary therapy with daratumumab
To investigate whether on demand dosing using population-based PK-models in VWD patients is reliable and feasible.
Primary objective: To classify the effect of the pharmacogenetic profile of CYP2C19 and CYP2D6 in HD gene carriers, compared to more classic medication prescribing parameters (such as age and comorbidities) on negative medication effects of HD-…
The objectives of this study are to acquire PPG data in patients during an ablation procedure simultaneously with reference measurements (ECG, ABP), investigate differences in PPG measurement between patients with failing and non-failing hearts, and…
Primairy objective:- Identify causes of secondary deterioration or failure to improve after viral encephalitis by studying activation of the immune system and production of autoantibodies.Secondary Objectives are to:- Determine if the delayed…
The primary objective of this study is to assess the improvement in clinical outcome of rTSA with Glenius one year after surgery. The secondary objectives are to gather patient-reported clinical outcomes, radiological outcomes (implant position/…
The aim of this prospective observational study is to assess the relation between femoral component rotation and patient reported outcomes in a large group of patients, and to define a clear cut-off point for revision for malrotated components.The…