366 results
We hypothesize that dietary supplementation with seaweed will improve glucose regulation in T2DM patients.
This study has been transitioned to CTIS with ID 2024-515755-37-00 check the CTIS register for the current data. Primary: • To investigate whether adjuvant atezolizumab treatment after standard, concurrent chemo-radiotherapy improves overall…
This study has been transitioned to CTIS with ID 2024-512030-15-00 check the CTIS register for the current data. Our primary objective is to assess the effect of diltiazem on coronary microvascular function as assessed by coronary reactivity testing…
Primary study aim:To determine the efficacy, in terms of the meadian progression-free survival, in patients with recurrent or metastatic endometrial cancer (including carcinosarcoma of the endometrium) receiving treatment with durvalumab and…
To evaluate the effect of baricitinib 4-mg QD and background standard-of-care therapy compared with placebo and background standard-of-care therapy on SLE disease activity.
The main objective of this study is to identify similarities and/or differences in social cognition between males and females with ASD at the behavioral, neuropsychological, and neurophysiological level during adolescence.
The primary objective is:• To evaluate the anti-tumor activity of bempegaldesleukin (NKTR-214) in combination with nivolumab by assessing the objective response rate (ORR) by Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1) per…
The primary objective of the study is to evaluate the clinical efficacy of antisense inhibitor of prekallikrein (ISIS 721744) in patients with hereditary angioedema (HAE) type 1 (HAE 1), HAE type 2 (HAE 2), or HAE with normal C1-inhibitor (C1-INH).…
Primary objectives1. To evaluate the pharmacokinetic (PK) profile of the parent compound (anethole trithione, ATT) and its main metabolite (5-[4-hydroxyphenyl]-3H-1,2-dithiole-3-thione, ATX ) following administration of a range of doses of i.v.…
This study has been transitioned to CTIS with ID 2024-513394-42-01 check the CTIS register for the current data. To assess long-term outcomes in low-immunological risk renal transplant patients beyond one year after transplantation using tacrolimus…
HV cohort 1Primary Objectives* To characterize the local tolerability of topical bimiralisib after 21 days* To characterize the systemic PK of topical bimiralisib after 21 daysSecondary Objective* To characterize the safety of topical bimiralisib…
This study has been transitioned to CTIS with ID 2024-517701-81-01 check the CTIS register for the current data. To assess the effect of citalopram on chest pain in patients with achalasia and to evaluate the effect of citalopram on esophageal…
To evaluate tailoring components in a web application for THA patients and to refine guidelines for tailored web applications for patients.Secondary objectives:- To assess how and how often THA patients use a prototype of the tailored web…
The primary objective of this study is to evaluate the safety and tolerability of intramuscular administration of the HIV-1 envelope protein ConM SOSIP.v7 gp140 vaccine, adjuvanted with MPLA liposomes, in HIV-uninfected adults. The secondary…
To evaluate the safety and efficacy of 177Lu-PSMA RLT in patients with R/M ACC and SDC with PSMA ligand uptake.
The objective of the study is to asses the efficacy and safety of intravenous ATB200 co-administration with oral AT2221 by evaluating the changes in key clinical outcome measures (eg, motor, respiratory, fatigue) in adult subjects with late-onset…
2.1 HypothesisPrimary infection with Mtb induces temporal changes in the innate immune system, known trained innate (aangeboren) immunity, and the extent of trained innate immunity influences subsequent activation of adaptive (verworven) immunity.2.…
To study the progression of high and pathologic myopia over time.
In this study, the agreement between liquid biopsy and tissue biopsy based KRAS/EGFR molecular diagnostics will be determined. Additionally, pairwise comparison of different liquid biopsy based molecular tests will be performed based on several…
In the specified patient groups, quantitative outcomes will be compared in both weight-bearing images and non-weight-bearing images. In detail, the location, displacement and rotation of individual bone fragments in the foot will be measured in 6…