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Mood, serotonin and social interaction

This project aims to study how changes in serotonin alter interpersonal functioning in adults with or without a first degree family member diagnosed with MDD. The primary goal is to investigate the effect of experimentally lowered brain serotonin…

Early Diagnostics of Depression in Primary Care.

Which of two strategies for early detection of depression in primary care performs best, i.e. results in higher number of identified depressions. The two strategies are:1. Active case finding of high risk patients by a nurse practitioner;2. Routing…

Interns InSight Study: The effect of mindfulnesstraining on the wellbeing and functioning of medical interns.

Based on current literature we hypothesize that mindfulness based stress reduction training reduces psychological distress and improves 'positive mental health' in medical interns. Possibly MBSR can prevent psychological distress in the…

Sex differences in Social Cognition in Autism Spectrum Disorders (ASD)

The main objective of this study is to identify similarities and/or differences in social cognition between males and females with ASD at the behavioral, neuropsychological, and neurophysiological level during adolescence.

Subjective neurosurgical evaluation of cervical spine synthetic *BoneMRI* CTs generated with convolutional neural networks.

The primary aim of this pilot study is to evaluate whether adding BoneMRI to the current workflow, which consists of a standard MRI scan and only on indication an X-ray or CT scan, improves the neurosurgeon satisfaction and certainty in the surgery…

First trimester differences in ultrasound parameters between pregnancies complicated by uteroplacental insufficiency and uncomplicated pregnancies: an observational study

Primary objective: To investigate whether there are differences in Doppler ultrasound (US) parameters measured during the routine 13-week scan between pregnancies complicated by uteroplacental insufficiency (UPI) and pregnancies not complicated by…

A phase 1 trial to assess P-gp mediated drug interactions with ASTX660 in healthy volunteers

The main purpose of this study is to investigate the effect of ASTX660 on how quickly and to what extent quinidine and fexofenadine are absorbed, distributed, broken down and eliminated from the body. Quinidine and fexofenadine have been chosen…

Bloodsamples of healthy controls for usage for biomediscal research laboratories.

To interpret pathophysiological data obtained in ongoing intranslational respiratory research on immunology, oncology and vascular diseases by comparison with healthy controls.

Treating microalbuminuria over 24 weeks in subjects with or without type 2 diabetes or hypertension

To assess the albuminuria lowering effects of dapagliflozin in subjects with and without diabetes or hypertension and persistent elevated albuminuria.

Phase I, Open-Label, 2-Period, Single-Sequence Study to Evaluate the Mass Balance and Absorption, Disposition, Metabolism and Excretion of [14C] enpatoran, and the Absolute Bioavailability of Enpatoran in Healthy Male Participants

The study includes 2 periods, Period 1 and Period 2. Subjects will participate in both periods. Period 1:The purpose of Period 1 is to investigate how quickly and to what extent enpatoran is absorbed, transported and eliminated from the body (this…

A 104-Week, Multicenter, Single-Arm, Long-Term, Phase 3 Extension Trial Investigating the Safety and Efficacy of Glepaglutide in Adult Patients with Short Bowel Syndrome (SBS) Completing the EASE SBS 2 Trial

This study has been transitioned to CTIS with ID 2024-513373-43-00 check the CTIS register for the current data. The objectives of this extension trial are to assess the long-term safety and maintenance of efficacy beyond 2 to 2.5 years of treatment…

An Open-label, Randomized, Crossover, Single Ascending Dose Pharmacokinetic Study of Continuous Subcutaneous Infusion of Lenalidomide Compared with Revlimid® Oral Capsules in Healthy Adult Male Subjects

The purpose of this study is to investigate how quickly and to what extend lenalidomide is absorbed and eliminated from the body (this is called pharmacokinetics). In this study the pharmacokinetics will be compared when lenalidomide is administered…

A GnRH Agonist IN pre-menopausal women STudy to treat severe Polycystic Liver Disease

This study has been transitioned to CTIS with ID 2023-506637-30-00 check the CTIS register for the current data. The main objective of this study is to determine whether lowering estrogen and progesterone levels with leuprorelin decreases liver…

Phase 1/2 Study to Investigate the Safety, Pharmacokinetics and Efficacy of Tinostamustine, a First-in-Class Alkylating Histone Deacetylase Inhibition (HDACi) Fusion Molecule, in Patients with Advanced Solid Tumors

The ability to fuse discrete small molecules with different types of pharmacologic activity has created remarkable opportunities in drug discovery and development. Bendamustine itself is a fusion molecule of the nitrogen mustard mechlorethamine and…

Signal TrAnsduction Pathway activity analysis for OVarian cancER treatment. STAPOVER study

This study aims to investigate the progression-free survival (PFS) according to RECIST 1.1 criteria on matched targeted therapy by STA-analysis (PFS2) in comparison to the PFS recorded on the therapy administered immediately prior to enrolment (PFS1…

A randomized, multi-center, open-label, cross-over study comparing critical errors, overall errors, training/teaching time, and preference attributes of the ELLIPTA dry powder inhaler versus the BREEZHALER dry powder inhalers, in adult participants with mild to moderate asthma.

Primary objective:To compare the proportion of participants who make at least one critical error after reading the section on inhaler use in the patient information leaflets (PILs) for ELLIPTA and BREEZHALER inhalersSecondary Objectives:To compare…

A Phase 1, open-label, single-dose, single-center, mass balance study of IPN60130 following a single 60-mg oral dose of IPN60130 containing 9 µCi of [14C]-IPN60130 in healthy male participants

In this study we will investigate how quickly and to what extent the new compound IPN60130 is absorbed, transported, and eliminated from the body (this is called pharmacokinetics). IPN60130 is radioactively labelled with carbon-14 (14C). In this way…

rTMS and cognitive control training in the context of depression

In this study, we want to combine rTMS and CCT to assess whether the combination of these two treatment would have synergistic effects and strengthen each other. We specifically want to assess the effect on mood and cognitive control, in a group of…

The cerebellum in anger and behavioural inhibition: An fMRI study

To assess the spatial topographical representation of anger and behavioural inhibition in the cerebellum.

Effect of oral magnesium supplementation on insulin sensitivity in people with type 2 diabetes

To investigate the effect of oral magnesium supplementation on insulin sensitivity in people with T2DM and a low serum magnesium concentration.