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The MPAC-study: validating craniocaudal tumor extension on MRI with histoPAthology in patients with Cervical cancer

To validate MRI for assessing craniocaudal tumor extension with histopathology using non-rigid egistration. In addition to 3 Tesla magnetic resonance T2-weighted imaging, diffusion weighted imaging (DWI) and dynamic contrast enhanced (DCE) imaging…

Observational cohort study to assess the association between mitochondrial function and recovery after a primary total knee arthroplasty in the elderly.

The objective of this study is to determine the association between mitochondrial function (activity and protein abundance of electron transport chain complexes I, II, III, IV and V) before TKA and change in KOOS score before versus 6 + 12 months…

Prostate Cancer Imaging with [18Flourine]Prostate Specific Membrane Antigen (PSMA) PET: a study on pharmacokinetics and test repeatability

The present study aims to:A) acquire a pharmacokinetic model of [18F]PSMA ([18F]-DCFPyl), by which simplified methods to quantify [18F]PSMA PET signal will be validated ; andB) assess the repeatability of those simplified quantitative method.

'To scope or not to scope' - Reducing oesophagoduodenoscopies for uncomplicated dyspepsia: a randomised controlled trial

Primary:To evaluate the superiority of a patient-centred, education based, clinical strategy to reduce the volume of endoscopies for dyspepsia in patients over 18 years of age without alarm symptoms, referred for OGD through open-access endoscopy…

The physiology of glucagon-like peptide-l receptor expression in patients with endogenous hyperinsulinism: correlation with histopathology

The main study aim is the in vivo and ex vivo investigation of the expression and distribution of the GLP-1R in the pancreas of children (< 16 years) with proven endogenous congenital hyperinsulinism who qualify forsurgery based on response…

A single arm multicenter biomarker study determining the response to taxane-based chemotherapy in metastatic breast cancer (MBC) patients with ESR1 mutations in cell-free DNA: TAX-ESR1 study.

The primary objective of this study is to assess the outcome of taxane- based chemotherapy in ER-positive MBC HER2-negative patients with progression after receiving endocrine therapy (with at least an AI) who have an ESR1 mutation measured in…

Phase II study of preliminary diagnostic performance of [68Ga]-NeoBOMB1 in adult patients with malignancies known to overexpress Gastrin Releasing Peptide Receptor

Primary Objective• To characterize preliminary targeting properties of [68Ga]-NeoBOMB1 in patients with malignancies known to overexpress GRPR.Secondary objectives• To assess safety and tolerability of a single diagnostic dose of [68Ga]-NeoBOMB1…

Using Interactive Virtual Reality Exposure to Understand Aggressive Behavior Problems in Youth; A pilot-study

The current pilot-study aims to validate Virtual Reality (VR) environments that elicit variance in virtual aggression and social information processing (SIP) and consist of the following research questions.1. Do children experience VR environments…

Examining brain phenotypes in carriers of (common) mutations in Polymerase gamma (PolG) using 7T MRI imaging.

I) To apply MRI techniques to identify anatomical and functional POLG related cerebral biomarkers. II) Investigate differences in said biomarkers between subjects and healthy controls.