167 results
To validate MRI for assessing craniocaudal tumor extension with histopathology using non-rigid egistration. In addition to 3 Tesla magnetic resonance T2-weighted imaging, diffusion weighted imaging (DWI) and dynamic contrast enhanced (DCE) imaging…
- To systematically determine the influence of disease activity of RA on the metabolic syndrome of patients with chronic RA (disease duration > 2 years).
The primary objective of this project is to investigate whether using prognostic factors from the PD, NP and PP domain will lead to a better prediction of treatment outcome in veterans with PTSD. Our secondary objective is to investigate whether the…
The primary objective of this study is to study whether driving ability may be affected in de novo, treatment naïve PD patients, by comparing their driving simulator performance to age- and sex-matched healthy controls (HC). The secondary objective…
The primary aim of this study is to investigate the safety and feasibility of ultra-high field magnetic resonance imaging (MRI) of the brain in neonates and to optimize scan protocols.
This study has been transitioned to CTIS with ID 2024-512030-15-00 check the CTIS register for the current data. Our primary objective is to assess the effect of diltiazem on coronary microvascular function as assessed by coronary reactivity testing…
Primary objectives: To evaluate safety of ZED88082A in combination with CED88004S. To determine appropriate ZED88082A/CED88004S dosing and PET imaging time-points. To evaluate pharmacokinetics (PK) of ZED88082A/CED88004S in patients before and…
The objective of the study is to determine the quality and usability of blood collection systems.
The objective of the study is to improve the detection of sepsis in primary care by developing a clinical decision rule for GPs, consisting of the most relevant clinical features and point-of-care (POC) measurements of biomarkers. This decision rule…
To determine the relationships between respiratory function, secretion management, RTIs and mortality in order to optimize medical decision-making.
2.1 HypothesisPrimary infection with Mtb induces temporal changes in the innate immune system, known trained innate (aangeboren) immunity, and the extent of trained innate immunity influences subsequent activation of adaptive (verworven) immunity.2.…
The primary objective of the entire study is to compare rogaratinib (BAY1163877) with chemotherapy (docetaxel, paclitaxel or vinflunine) in terms of prolonging the Overall survival (OS) of patients with FGFR positive urothelial carcinoma.
The objective of this study is to determine the association between mitochondrial function (activity and protein abundance of electron transport chain complexes I, II, III, IV and V) before TKA and change in KOOS score before versus 6 + 12 months…
The present study aims to:A) acquire a pharmacokinetic model of [18F]PSMA ([18F]-DCFPyl), by which simplified methods to quantify [18F]PSMA PET signal will be validated ; andB) assess the repeatability of those simplified quantitative method.
Main objective is to compare the incidence of subclavian vein thromboses after TLE by manual traction alone versus TLE with use of the mechanical rotational dilator sheath in case of fibrous adhesions hampering extraction by manual traction alone.…
Primary:To evaluate the superiority of a patient-centred, education based, clinical strategy to reduce the volume of endoscopies for dyspepsia in patients over 18 years of age without alarm symptoms, referred for OGD through open-access endoscopy…
This study has been transitioned to CTIS with ID 2024-520392-27-00 check the CTIS register for the current data. The primary objective is to evaluate the difference in 68Ga-exendin tracer accumulation in the pancreas of women with and without a…
Primary objective:* Assess the test-retest repeatability and reproducibility of radioligand [11C]-UCB-J binding.Secondary objective:* Compare the precision and accuracy of PET data analysis using 60 versus 90 minutes of scan data.* Assess group…
In this study, the agreement between liquid biopsy and tissue biopsy based KRAS/EGFR molecular diagnostics will be determined. Additionally, pairwise comparison of different liquid biopsy based molecular tests will be performed based on several…
In the specified patient groups, quantitative outcomes will be compared in both weight-bearing images and non-weight-bearing images. In detail, the location, displacement and rotation of individual bone fragments in the foot will be measured in 6…