35 results
Primary Objective: To investigate the efficacy and safety of octreotide treatment (a somatostatin analogue) in decreasing the transfusion requirements (IV iron infusions and / or red blood cell transfusions) in patients with GI bleeding caused by…
The objectives of this study are: 1) to assess the feasibility, accuracy and efficacy of simultaneous, conventional and micro-electrode mapping using the QDOT catheter to delineate and ablate the functional substrate of post-MI VT compared to…
Primary Objective: The first objective of this study is to evaluate efficacy of adjuvant HAIP chemotherapy after repeat hepatectomy for recurrent CRLM in the Erasmus MC.Secondary Objective(s): The second objective is to determine treatment related…
The objectives and relevant endpoints of the study are as follows:Primary: To assess the safety and tolerability of ATL001 as amonotherapy and in combination with pembrolizumabSecondary: To evaluate the clinical efficacy of ATL001treatment as a…
The aim of this PMCF study is to confirm the clinical safety and performance aspects of intracranial catheter placements forthe medical indications, hydrocephalus of any origin or ICP elevation. The study design requires determination of…
Goal of the UMBRELLA Study is the optimization of existing MRI protocols and processing techniques required for MRI guided radiation treatment on the Marlin system (MRI of the MR-Linac) and diagnostic MRI scanners in the radiology department needed…
The primary objective of this study is to determine the effect of exposure to hypoxia on the reaction time to visual stimuli presented at a FoV of 30 and 60 degrees horizontally and vertically.The secondary objective of this study is it to determine…
Objectives (all are exploratory):• To measure and analyze 89Zr-Df-IAB22M2C uptake cluster of (CD8+ PET signal) at and between baseline and post-treatment in tumor lesions and reference normal tissues, including T-cell rich tissues, using PET imaging…
This study has been transitioned to CTIS with ID 2024-510778-26-00 check the CTIS register for the current data. Primary Objective:To evaluate the efficacy of LN-145 measured by objective response rate (ORR) usingResponse Evaluation Criteria in…
- The objective of the proposed clinical trial is to evaluate the safety and effectiveness of the Navitor Transcatheter Aortic Heart Valve in patients with severe, symptomatic aortic stenosis who are at intermediate or low risk of surgical mortality…
The objective of this clinical study is to evaluate the safety and effectiveness of the CapBuster System in crossing de novo or restenotic chronic total occlusions in infrapopliteal peripheral arteries.
The primary aim of the proposed study is to test the effectiveness of CBT + ERT in reducing depressive and anxiety symptoms against CBT alone in adolescent patients (aged 13-19) with depressive or anxiety disorders in a randomized controlled trial (…
The objective is to validate the effects of chronic roflumilast treatment on cognitive function (i.e. episodic memory) by means of behavioral tasks, in people suffering from cognitive impairments at least 1 year after stroke.
The aim of this study is to investigate whether a smartphone app can increase physical activity in PDpatients for a long period of time (one year). The secondary aim is to test the potential effects of an increase in physical activity on physical…
Main: To evaluate the efficacy of continuing SZC as part of the discharge medications, compared to SoC, in maintaining NK Secondary:To evaluate the effect of continuing SZC as part of the discharge medications, compared to SoC:1. in reducing the…
The aim of this study is to investigate whether prehabilitation could enhance preoperative physical condition and weight loss before bariatric surgery and induce a lifestyle behavior change.
The overall aim of the present study is to develop and test a cognitive rehabilitation intervention for OHCA patients with cognitive deficits. The intervention will be designed to improve cognitive functioning in the domains of attention, memory,…
Primary Objectives:• To assess the efficacy of soticlestat in reducing major motor drop (MMD) seizure frequency as add-on therapy to SOC as compared with placebo during the full treatment period (titration + maintenance).For European Medicines…
The aim of the Mint study is to investigate the effectiveness of peppermint oil capsules compared to placebo capsules in reducing abdominal pain intensity in these children. In addition, we investigate the effect of peppermint oil capsules compared…
Primary Objective: to explore the effect of SMIs on the pharmacokinetics of DOACs in patients with solid tumours who receive a DOAC and SMI concurrently. Secondary Objective(s): - To determine the percentage of patients with DOAC peak and trough…