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Quantifying various effects of closed-loop Spinal Cord Stimulation (SCS) on pathophysiological mechanisms in Complex Regional Pain Syndrome (CRPS); an explorative study

To evaluate and quantify the various clinical effects of closed-loop SCS versus open-loop SCS on the underlying pathophysiological effects in CRPS.

PeRsonalIzed MEdicine in Rheumatoid Arthritis (PRIMERA trial): a multicenter, single-blinded, randomized controlled trial comparing usual care with a tailor-made approach

This study has been transitioned to CTIS with ID 2024-511530-12-01 check the CTIS register for the current data. We hypothesize that treatment of RA can be individualized by taking into account the presence of autoantibodies and quick response to…

The Impact of Cognitive Behavioral Therapy (CBT) on Treatment Outcome after Lumbar Spinal Fusion Surgery in Patients with High Pain Catastrophizing: a Two-center Randomized Controlled Trial of CBT vs. Education

To assess the impact of CBT on treatment outcome after lumbar spinal fusion surgery in patients with high pain catastrophizing, a two-center randomized controlled trial comparing CBT care to education.

Pharmacological Magnetic Resonance Spectroscopy

To demonstrate that combined phMRI/phMRS can characterize the dose-dependent neurometabolic response to S-ketamine.

Economic evaluation of the surgical treatment of cervical myelopathy, radiculopathy, or myeloradiculopathy: anterior cervical discectomy with arthroplasty versus anterior cervical discectomy with fusion.

The aim of the proposed study is to examine whether ACDA compared to ACDF is preferable in terms of costs, effectiveness and utility from a hospital and a societal perspective.