63 results
To answer the question if structural changes of the brain and impairments of cognitive functioning in type 1 diabetes are related to the presence of microvascular disease we will· Compare brain structure (brain volume, white matter lesions) and…
Are changes in cognitive functioning related to structural changes in the brain in patients with type 1 diabetes mellitus. How are these changes related to diabetic complications like duration of chronic hypoglycaemia, disease duration and presence…
The primary objective is to develop algorithms that define digital biomarkers for disease progression in Progressive Supranuclear Palsy patients. The biomarkers, when developed systematically, can eventually serve as primary or secondary clinical…
to test the feasibility of the study protocol for operability, intensity and logistics and to test whether the chosen activities can be measured as expected, in order to provide a guideline for testing maximum aerobic capacity and the metabolic…
This study has been transitioned to CTIS with ID 2024-516057-42-00 check the CTIS register for the current data. The primary aim is to examine whether early addition of IVIg to standard treatment with prednisone in patients with newly diagnosed…
The main objectives of this study are(I) to compare the sensitivity of CT-venography and ultrasound for screening-detected, catheter-related thrombosis in cancer patients and (II) to assess intrinsic coagulation levels in cancer patients prior to…
Primary objective is assessment of the pharmacokinetic profile of MPD in pregnancy. Secondary objectives are the safety and efficacy of any use of MPD during pregnancy.
This study has been transitioned to CTIS with ID 2024-513412-10-00 check the CTIS register for the current data. Phase 1: • To determine the MTD/RP2D regimen of brigatinib monotherapy when administered in pediatric and AYA patients with ALK+ ALCL or…
The primary objective of this study is to compare cholinergic innervation of the cerebral cortex of GBA-PD and non-GBA-PD patients, using [18]FEOBV PET imaging of the brain.
Fluorescence guided surgery for intra-operative detection of meningioma using Bevacizumab-IRDye800CW
In the present study, we aim to perform a feasibility study with Bevacizumab-IRDye800CW in patients with meningioma who are scheduled for elective surgical resection. The ability of fluorescence imaging to identify residual meningioma tissue that is…
To evaluate the long-term safety and performance of the HARPOON* MVRS for use in patients presenting with severe degenerative mitral regurgitation due to posterior leaflet prolapse in the post-market phase.
The overarching goal is to optimise the treatment of KD in children/adolescents across Europe.KD-CAAP will test the hypothesis that adding immediate adjunctive corticosteroid treatment to IVIGand aspirin will reduce CAA rates in unselected KD…
To study the long-term changes in DNA methylation and gene expression in sepsis survivors and their association with long-term morbidity and mortality after sepsis.
To evaluate the effectiveness of a peer-led, video-based self-management support programme for patients with advanced cancer and their relatives. The programme aims to improve the wellbeing of patients with advanced cancer and their relatives,…
To demonstrate safety and efficacy of Firehawk® rapamycin eluting stent system in comparison to currently approved 2nd generation DESin wide clinical use.
The objective of this study is to assess the non-inferiority of analgesic efficacy of ESP vs PVB for patients undergoing unilateral mastectomy followed by immediate reconstruction.
This study has been transitioned to CTIS with ID 2024-513924-41-01 check the CTIS register for the current data. The primary objective of this study is to compare effectivity of suboxone and methadone on reducing opioid misuse.Secondary objectives…
We hypothesize that one possible mechanism may involve the free radical formation. Therefore, measuring free radical generation will be correlated to the diversity of seminal microbiota and related with semen-parameters defined by the WHO guidelines…
The main objective of PD0053 is to provide POC for the efficacy of the ASYN misfolding inhibitor UCB0599 in reducing disease progression in study participants with early-stage PD, and to instruct later stage development. The ultimate goal is to…
The primary objective of the study is to test whether peripheral endothelial function assessed using Laser speckle contrast analysis and CED measured with ICFT are correlated.