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Dietary changes and markers of stress and depression in freshman bachelor students at Wageningen University

Our first primary research objective is to investigate if and how students are changing their diet toward a more plant-based diet. Our second primary objective is to assess changes in stress by using subjective methods (questionnaires) and a…

A 5-year Natural History Study in LAMA2-related muscular dystrophy and SELENON-related myopathy: the extended LAST STRONG Study

With the extended LAST STRONG Study, we aim to (1) collect 3-year and 5-year natural history data, (2) implement the natural history data collection into clinical care and international guidelines (reach trial readiness), and (3) do in-depth…

Efficacy of Pectoral Nerve (PECS II) Block with Liposomal Bupivacaine versus Levobupivacaine for Patients undergoing a Mastectomy: A Prospective Randomized Controlled Trial.

This study has been transitioned to CTIS with ID 2024-515183-30-00 check the CTIS register for the current data. The aim of this prospective randomized, double blind study is to evaluate the analgesic effects of pre-operative PECS II-block with (…

A Multi-Centre Study in Patients Undergoing Total Knee Replacement with Smith+Nephew Porous Total Knee Arthroplasty (TKA) System.

The primary objective is to assess 2-year survivorship of Total Knee Arthroplasty (TKA) procedures performed using the Smith+Nephew (S+N) Porous Knee System. The secondary objective is to generate safety and performance evidence up to 5 years post-…

HealThy fAt, haPpy mIcRobiome - Proof-of-Concept Study

To assess the effect of dietary lipids on the small intestinal microbiome in humans (proof-of-concept), the primary objective is to measure production of microbiota-derived lipid metabolites in the human small intestine after consumption of a high-…

nCLE-guided bronchoscopy for peripheral lung cancer diagnosis: a Randomized Controlled Trial

To evaluate the added value of nCLE-imaging to conventional bronchoscopic peripheral lung lesion analysis on the diagnostic yield.

Comparison of a solid state versus balloon esophageal catheter for estimation of pleural pressure in surgical ICU patients

To evaluate the accuracy of Pes measurement with a solid-state catheter during controlled and assisted ventilation.

A Phase 1/2 Randomized, Umbrella Study to Evaluate the Safety and Efficacy of Pembrolizumab Plus Enfortumab Vedotin (EV) in Combination With Investigational Agents Versus Pembrolizumab Plus EV, as First-Line Treatment for Participants With Advanced Urothelial Carcinoma (KEYMAKER-U04): Substudy 04B

This study has been transitioned to CTIS with ID 2023-506385-30-00 check the CTIS register for the current data. Primary Part 1:-To evaluate ORR in participants treated with MK-4280A plus EV (Arm A), MK-7684A plus EV (Arm B), and pembrolizumab plus…

A Phase 1, Open-label, Multicenter Study of the Safety, Pharmacokinetics, and Pharmacodynamics of MK-4464 as Monotherapy and in Combination with Pembrolizumab in Participants with Advanced / Metastatic Solid Tumors

This study has been transitioned to CTIS with ID 2023-504855-28-00 check the CTIS register for the current data. To determine the safety and tolerability and to establish a preliminary RP2D and/or an MTD or an MAD of MK-4464 administered via IV…

A Phase 2, Multicenter, Multi Arm, Study to Evaluate MK-1308A (Coformulated
quavonlimab (MK-1308)/pembrolizumab) Versus Other Treatments in
Participants with Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient
(dMMR) Stage IV Colorectal Cancer: (MK-1308A-008)

This study has been transitioned to CTIS with ID 2022-502100-70-00 check the CTIS register for the current data. The aim of this research is:1. To test the safety of MK-1308A, MK-4280A, MK-7684A and MK 4830 + pembrolizumab against pembrolizumab as…

A PHASE Ib/II, OPEN-LABEL, MULTICENTER STUDY EVALUATING THE SAFETY, ACTIVITY, AND PHARMACOKINETICS OF GDC-6036 IN COMBINATION WITH OTHER ANTI-CANCER THERAPIES IN PATIENTS WITH PREVIOUSLY UNTREATED ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER WITH A KRAS G12C MUTATION

This study has been transitioned to CTIS with ID 2023-507171-22-00 check the CTIS register for the current data. The purpose of this study is to evaluate the safety, pharmacokinetics, and activity of GDC-6036 combined with other anti-cancer…

Hemodynamic characterization of the respect and resect approaches in mitral valve repair surgery: a 4D-flow MRI study (RES-P-ECT 4D trial)

The aim of this study is to investigate potential differences in blood flow patterns, wall shear stress and energy loss in patients after mitral valve repair with the resect and respect approach.

Selective Control Assessment of the Lower Extremities to probe the increased metabolic cost of walking after Stroke

The main objective is to examine the relationship between energy cost and (1) hip extensor and knee extensor co-activation, (2) plantar flexor and hip extensor co-activation and (3) plantar flexor and knee extensor co-activation in able-bodied…

Study on PhArmacokiNetics of first liNe Antiretrovirals in healthy Breastfeeding volunteers
(PANNA-B PK)

This study has been transitioned to CTIS with ID 2023-510232-36-00 check the CTIS register for the current data. to determine the concentration of currently often used ARV (doravirine, raltegravir, bictegravir, tenofovir alafenamide, emtricitabine)…

Preoperative Intermittent Fasting versus Carbohydrate Loading to Reduce Insulin Resistance: a Randomised Controlled Trial

The main objective is to investigate whether preoperative TRF improves perioperative insulin resistance compared to CHL and standard preoperative fasting.Our secondary objective is to investigate the feasibility of preoperative TRF in terms of…

DEnosumab for the treatment of FIbrous Dysplasia/McCune-Albright Syndrome in adults (DeFiD): a randomized double-blind placebo-controlled trial

This study has been transitioned to CTIS with ID 2024-511090-30-00 check the CTIS register for the current data. To investigate whether 3 monthly Dmab will improve the clinical, radiological and biochemical manifestations of FD bone lesions.

Evaluation of GeranylGeranylAcetone in heart failure with preserved ejection fraction

Primary objectivesTo study whether Geranyl-Geranyl Acetone (GGA) reduces left ventricular (LV) diastolic dysfunction in patients with HFpEF compared to placebo (and to assess/confirm its effectiveness and safety in patients with HFpEF)Secondary…

Peroperative Administration of Tranexamic acid in Roux-en-Y and one-anastomosis gastric bypass to reduce hemorrhage rates (PATRY study): a randomized controlled trial

This study has been transitioned to CTIS with ID 2024-513570-22-00 check the CTIS register for the current data. This trial aims to investigate whether peroperative administration of TXA reduces haemorrhage rates in patients who undergo metabolic…

Phase 3, Multicenter, Randomized, Double-Masked, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Tinlarebant in the Treatment ofStargardt Disease in Adolescent Subjects

This study has been transitioned to CTIS with ID 2024-513483-26-00 check the CTIS register for the current data. To assesses the efficacy of Tinlarebant in slowing the rate of growth of atrophic lesion(s) in adolescent subjects with STGD1.

ABCD-study Phase 7: follow-up measurements at age 19-20 years*

Objectives of phase 7 of the ABCD-study are:(i) to follow-up on growth trajectories during childhood/adolescence and identify lifestyle and environmental factors that influence thesetrajectories;(ii) to follow-up on cardiometabolic health during…