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To understand, from the perspective of the 3-hit hypothesis of psychopathology, individual differences in the neuropsychiatric outcome of previous glucocorticoid (GC) excess in treated Cushing patients.
To study the effects of transient severe endogenous stress hormone exposure on the structure and functioning of brains circuitry regulating emotion, and the association with cognition and psychopathological symptoms.
• To investigate if FD in CRPS is associated with specific structural and functional changes of the brain.• If so, to find out which of these changes are specific for FD in CRPS, i.e., independent regardless the clinical setting (pain versus…
Objectivesi)) To study whether reproductive hormones play a role in migraine susceptibility in malemigraine patients; ii) to study functionality of the trigeminal system prospectively duringinterictal and premonitory phases of the migraine attack (…
Testing the hemostasis of oral surgery wounds with the HemCon dental dressing in patients on oral anticoagulation therapy
The objective of this study is to gain insight in the effects of the triage method on the identification of children with mental or physical problems, the basic JGZ care for children age 4-12, the extra care for children with mental or physical…
Is there a better way to detect REM sleep atonia than with the current visual analysis of submental muscle EMG? To which degree do muscles become atonic during REM sleep? Which muscle exhibit the largest decrease? How can this decrease best be…
Primary:To investigate the effect of VLCD (very low calorie diet) in obese patients with type 2 DM and cardiovascular complications on cardiac function, pulse wave velocity and myocardial triglyceride contentSecondary:To investigate the effect of…
pg 7-8One objective of this study is to assess whether preventive health consults for elderly people reach the elderly and whether the consults result in a better attendance to existing interventions. This objective is operationalized by the…
Primary Objective:To validate the ExSpiron©, a device for non-invasive monitoring of respiratory volume in patients with ALS during spontaneous breathing and during NIV.Secondary Objective(s):• to observe the difference between nocturnal respiration…
This protocol serves to establish a formal procedure to allow collection of blood samples from healthy volunteers within the Department of Internal Medicine to be used for development and/or optimization of transplantation-related in vitro assays
This study has been transitioned to CTIS with ID 2024-514767-26-00 check the CTIS register for the current data. To find the maximum tolerated dose of glass yttrium-90 (90Y) microspheres (TheraSphere®), when combined with DEBIRI in patients with…
This study has been transitioned to CTIS with ID 2023-503382-29-00 check the CTIS register for the current data. * Evaluate the effect of lumasiran on plasma oxalate in patients who are not on dialysis therapy Cohort B* Evaluate the effect of…
The present study aims to address the limitations of earlier research, by employing a large sample size, and investigating the possibility that music therapy has an effect on wellbeing of people with dementia when using blinded outcome assessments…
This will be an explorative study to examine the value of high-resolution ultrasound (HRUS) of the peripheral nerves in NF1 patients. The primary objective of this study is to determine HRUS abnormalities in a large group of NF1 patients, and to…
Primary objective• To determine the optimal dose of IMU-838 to induce symptomatic remission (based on stool frequency [SF] and abdominal pain [AP], as assessed in the Crohn*s Disease Activity Index [CDAI] patient reported outcome [PRO]-2) in…
1) Establish a comprehensive clinical and antibody profile of autoimmune synaptic encephalitis in dementia syndromes. 2) To assess outcome and provide diagnostic guidelines who to test and in whom testing will be unnecessary, and elucidate…
This study has been transitioned to CTIS with ID 2024-512736-29-00 check the CTIS register for the current data. Primary Objective1. To evaluate the safety and tolerability of long-term dosing of losmapimod tablets in subjects with FSHD1Secondary…
This study has been transitioned to CTIS with ID 2024-510630-40-00 check the CTIS register for the current data. The objective of this prospective, randomized study is to investigate the efficacy and safety of HSCT compared to the comparator group (…
Primary objective: 1. To compare the difference in thyroid uptake of a low tracer dose radioactive iodine (10 MBq 123I or 37 MBq 123I) (1a), in DTC patients after thyroidectomy, before and after a LID of 7 days (1b).Primary objective described in…