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Genetic aspects of Sterno-costo-clavicular hyperostosis

• To construct the pedigree of patients with SCCH with special attention to the presence of other inflammatory disorders such as inflammatory bowel disease, psoriasis, inflammatory arthritis in patients and kindreds.• To identify the gene mutation…

Validation of the Quantified Myasthenia Gravis strength score (QMG Score): is it both sensitive and specific?

What values are normal in healthy controls for endurance and force? Are these values the same for men and female? What is the effect of age to these normal values? What are endurance and force for patients with myasthenia gravis? Are there specific…

Effect of simvastatin on myocardial triglyceride accumulation, cardiac function and al vessel wall thickness in patients with type 2 diabetes mellitus

To study the possible beneficial effect of simvastatin on accumulation of triglycerides in the myocardium of patients with DM2 and the effect on vessel wall thickness using magnetic resonance imaging and spectroscopy

Social-emotional development of children in the younger age with an Cochlear Implant and/or children with autism.

to be translated

ILLUMINATE-C: A Single Arm Study to Evaluate Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Lumasiran in Patients with Advanced Primary Hyperoxaluria Type 1 (PH1)

This study has been transitioned to CTIS with ID 2023-503382-29-00 check the CTIS register for the current data. * Evaluate the effect of lumasiran on plasma oxalate in patients who are not on dialysis therapy Cohort B* Evaluate the effect of…

An Open-Label Pilot Study of Losmapimod to Evaluate the Safety, Tolerability, and Changes in Biomarker and Clinical Outcome Assessments in Subjects With Facioscapulohumeral Muscular Dystrophy 1 (FSHD1) with Extension

This study has been transitioned to CTIS with ID 2024-512736-29-00 check the CTIS register for the current data. Primary Objective1. To evaluate the safety and tolerability of long-term dosing of losmapimod tablets in subjects with FSHD1Secondary…

A phase 2, multicenter, randomized, double-blind, placebo-controlled, dose-finding trial to evaluate the efficacy and safety of IMU-838 for treatment of patients with active Crohn*s disease with an option for open-label treatment extension (CALDOSE-2)

Primary objective• To determine the optimal dose of IMU-838 to induce symptomatic remission (based on stool frequency [SF] and abdominal pain [AP], as assessed in the Crohn*s Disease Activity Index [CDAI] patient reported outcome [PRO]-2) in…

*Validation of the ExSpiron© in patients with Amyotrophic Lateral Sclerosis*; a pilot study

Primary Objective:To validate the ExSpiron©, a device for non-invasive monitoring of respiratory volume in patients with ALS during spontaneous breathing and during NIV.Secondary Objective(s):• to observe the difference between nocturnal respiration…

Pathogenic Antibodies and (Rapidly Progressive) Dementia syndromes

1) Establish a comprehensive clinical and antibody profile of autoimmune synaptic encephalitis in dementia syndromes. 2) To assess outcome and provide diagnostic guidelines who to test and in whom testing will be unnecessary, and elucidate…

Individual music therapy and wellbeing in nursing home residents with dementia
A study protocol of a randomized controlled trial

The present study aims to address the limitations of earlier research, by employing a large sample size, and investigating the possibility that music therapy has an effect on wellbeing of people with dementia when using blinded outcome assessments…

Development and optimization of transplantation-related in vitro assays

This protocol serves to establish a formal procedure to allow collection of blood samples from healthy volunteers within the Department of Internal Medicine to be used for development and/or optimization of transplantation-related in vitro assays

Combining drug-eluting bead transarterial chemoembolisation and radioembolization for treatment of colorectal liver metastases: DEBIR90Y study

This study has been transitioned to CTIS with ID 2024-514767-26-00 check the CTIS register for the current data. To find the maximum tolerated dose of glass yttrium-90 (90Y) microspheres (TheraSphere®), when combined with DEBIRI in patients with…

The value of nerve ultrasound in patients with neurofibromatosis type 1

This will be an explorative study to examine the value of high-resolution ultrasound (HRUS) of the peripheral nerves in NF1 patients. The primary objective of this study is to determine HRUS abnormalities in a large group of NF1 patients, and to…

A Phase 3, Randomized, Double-Blind Study of Adjuvant Immunotherapy with Nivolumab versus Placebo after Complete Resection of Stage IIB/C Melanoma (CA209-76K)

This study has been transitioned to CTIS with ID 2022-502354-14-00 check the CTIS register for the current data. Primary Objective:To measure the efficacy provided by nivolumab therapy on its own compared to placebo in participants who have had…

Androgen Deprivation therapy for Oligo-recurrent Prostate cancer in addition to radioTherapy

This study has been transitioned to CTIS with ID 2024-511252-41-00 check the CTIS register for the current data. The aim of the current study is to extend the time to develop new disease progression in prostate cancer patients with recurrent disease…

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Upadacitinib in Subjects with Giant Cell Arteritis. SELECT-GCA

This study has been transitioned to CTIS with ID 2023-505476-29-00 check the CTIS register for the current data. This study consists of two periods. The objective of Period 1 is to evaluate the efficacy of upadacitinib in combination with a 26-week…

Master Protocol to Assess the Safety and Antitumor Activity of Genetically Engineered NY-ESO-1-Specific (c259) T Cells, alone or in combination with other agents, in HLA-A2+ Participants with NY-ESO-1 and/or LAGE-1a Positive Solid Tumors (IGNYTE-ESO) (study 208467)

This study has been transitioned to CTIS with ID 2024-513032-14-00 check the CTIS register for the current data. Primary:To evaluate the efficacy of NY-ESO-1-Specific (c259) T Cells, alone or in combination with other anti-cancer agents, in HLA-A*02…

A Phase III, multicenter, randomized, double-blind study to assess efficacy and safety of two doses of crizanlizumab versus placebo, with or without hydroxyureal/hydroxycarbamide therapy, in adolescent and adult sickle cell disease patients with vaso-occlusive crises (STAND)

This study has been transitioned to CTIS with ID 2023-508689-14-00 check the CTIS register for the current data. To compare the efficacy of 7.5 mg/kg of crizanlizumab versus placebo on the annualized rate of VOC leading to healthcare visit, in…

The roles of Attachment Style and Autonomy on Inter-Personal Distance and respons time in Virtual Reality in patients with persistent psychopathology.

Examining inter-personal distance in Virtual Reality in patients with persisting psychopathology and a control group in order to assess the association with attachment styles. Differences in gender will also be examined. Primary research question…

A Phase 3 Randomized, Double Blind Study of Pembrolizumab Plus Gemcitabine/Cisplatin versus Placebo Plus Gemcitabine/Cisplatin as First-Line Therapy in Participants with Advanced and/or Unresectable Biliary Tract Carcinoma (KEYNOTE 966)

This study has been transitioned to CTIS with ID 2023-506657-38-00 check the CTIS register for the current data. To compare pembrolizumab plus gemcitabine plus cisplatin to placebo plus gemcitabine plus cisplatin with respect to overall survival (OS…