71 results
The primary objective of this study is to analyse the microenvironment of the primary tumour and sentinel and non-sentinel lymph node(s) (i.e. various T-cell populations, antigen presenting cells and myeloid-derived suppressor cells) in patients…
The primary objective of this study is to analyse the microenvironment of the tumour, (sentinel) lymph nodes (i.e. various T-cell populations, antigen presenting cells and myeloid-derived suppressor cells) in patients with vulvar carcinoma. The…
Primary Objective: To evaluate persisting pulmonary morbidity and echocardiographic signs of pulmonary hypertension in young adults born with CDH that interfere with physical fitness and participation in society.Secondary Objective(s): To evaluate…
We aim to determine if in vivo MSOT can distinguish benign from malignant thyroid nodules by correlating and validating optoacoustic signals in vivo with pathology results.
The primary objective of this study is to optimize a workflow for identification of circulating melanoma cells in LA using flow cytometry. Secondary objectives include the detection of known mutations in different CMC subsets.
Primary Objectives: - Is IBA non-inferior to CBT in treating patients with OCD?Secondary Objectives:-* Does treatment modality predict pre- to posttreatment changes in neural networks, and is this related to symptom reduction and changes in…
Aim:To evaluate the effects of a structured nursing supportive intervention on family caregivers in palliative home care. Question:What are the effects of a new nurse-led supportive intervention on family caregivers* preparedness and burden?
We hypothesize that synchronous tACS in the theta range will cause an enhancement of fronto-parietal brain synchronization and improvement in EF of MCI patients.We aim to apply tACS in the theta range over the left frontal and parietal areas of…
To evaluate the performance of an optimized glaucoma genetic risk score (GRS) by inviting genotyped individuals from the population-based Lifelines cohort for in-depth ophthalmic examinations.
1. The primary objective of the European NAFLD Registry observational study is to assemble a cohort of well-characterised patients with Non-Alcoholic Fatty Liver Disease (NAFLD) and to collect associated clinical information, biological samples and…
The current study will investigate the beneficial effects of an experimental congruent movement training (eye and hand movements), compared to a control intervention with only eye movements (visual scanning therapy). Primary objectives are changes…
Our main objective is to evaluate the effect of RAS inhibition on ascending aortic dilatation rate by cardiac magnetic resonance (CMR) imaging in CoA patients, and compare this to CoA patients without RAS inhibition. As secondary objectives, we aim…
1. To determine the feasibility of performing a few functional magnetic resonance imaging (fMRI) tasks and clinical neurophysiological measurements in patients with mild to moderate AD.2. To validate the visual perception fMRI task in healthy…
Objective: In this project we, as a collaborative network of Netherlands academic hospitals from Utrecht, Amsterdam, Rotterdam, Leiden and Groningen, propose to further optimize and validate MG-NIPD at early stages (week 8-10) of pregnancy, in order…
The goal is to gain more clarity in the wishes of the patient and family members by means of Advance Care Planning with the help of an early outpatiënt consultation of the PACT. This is hoped to show the intervention leads to a reduced number of…
The primary aim of the study is to generate a cohort, which provides information on sex- and gender differences in: prevalence and incidence of (clinically relevant clusters of) PFS, risk factors and prognostic factors for PFS, factors that reveal…
Relevancy: Groin explorations are regularly performed procedures in vascular surgery. To date, the chosen technique will be either electrocoagulation or the Ligasure, depending on the operator*s preference. It is yet unclear whether the chosen…
The primary objective of this project is to map differences in joint loading between athletes receiving visual feedback and those who will not receive visual feedback in both retention and transfer to field-specific situations. From there. we will…
To prospectively study the effect of salt restriction on the rise in blood pressure in response to anti-cancer treatment with the VEGF inhibitor sunitinib and regorafenib.
The primary objective of this study is to investigate the effects of stress exposure on the epigenetic profile of preterm infants. Secondary objectives include to determine (a) the relation between stress exposure and early childhood outcomes (…