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Effectivity and Working Mechanisms of Schema Therapy for patients with a Treatment Resistant Depression

Main research question:Does group-based schema therapy result in a reduction of depressive symptoms when comparing symptom change during the treatment to patients* baseline symptom level?Sub research questions:Does group-based schema therapy result…

Corcym Mitral, Aortic aNd Tricuspid post-maRket Study in a reAl-world setting

Monitor ongoing safety and performance of the CORCYM heart valve devices and accessories for aortic, mitral and tricuspid valvular diseases in a real-world setting.

Effect of tactile breathing guidance on oxygen saturation during exposure to hypoxia

The primary objective is to determine whether tactile breathing guidance is effective in increasing SpO2 while engaged in a cognitive task during exposure to hypobaric hypoxia.The secondary objectives are:1. Determine whether a difference in SpO2…

A Phase 1a/1b Study Exploring the Safety and Tolerability of INCB081776 in Participants With Advanced Malignancies

This first-in-man study will investigate the safety and tolerability as well as establish a recommended dose of INCB081776 as a monotherapy (Part 1) and then in combination with INCMGA00012 (Part 2) in participants with advanced malignancies. During…

'A clinical study of the difference in the effect of pocket-irrigation in the treatment of peri-implantitis compared to a conventional therapy, the airflow: a randomized controlled trial'

The aim of this study is to assess the effectivity of the Fluxion, in combination with Bluem (Bluem, Bluem Europe, Zwolle, The Netherlands) and in combination with demineralised water. This aims to find a minimally invasive treatment for peri-…

A randomized controlled trial to investigate the (cost)effectiveness of oral immunotherapy with different allergens in young children with an established food allergy.

What is the clinical- and cost-effectiveness of early low-dose oral immunotherapy aimed at long-term tolerance induction in children under the age of 30 months with an established food allergy compared to routine care?What is the effect of early low…

T-REEX: Phase locked TRanscranial Electrical EXcitation

The aim of this study is to demonstrate that accurate brain stimulation is possible in anatomical location and timing.

Response and Toxicity Prediction by Microbiome analysis in locally advanced NSCLC treated with IO (durvalumab) after Chemoradiotherapy (sequential and concurrent)

The predictive value of the microbiome (throat swabs and stool samples) to identify patients who will relapse during durvalumab treatment after CRT (False negative Rate) at 6 months. Exploratory endpoints include the effects of antibiotic therapy…

Biomarker identification of radionuclide therapy-induced radiation responses.

This is a pilot study to validate the possibility of determining the effect of PRRT with 177Lu-DOTATATE on transcriptional regulation and DNA damage induction in PBMCs and how this is related to the radiation dose.We will also want to explore if we…

Breast reconstruction and neoadjuvant radiotherapy, a changing algorithm.

The purpose of the pilot study is to assess acute post-surgical complications following mastectomy and immediate breast reconstruction after NART. We hypothesize that NART will avoid the negative effects of PMRT on the capsule of an implant, or on…

A Randomised Open-Label Trial of Early, Very High-Titre Convalescent Plasma Therapy in Clinically Vulnerable Individuals with Mild COVID-19

To determine whether convalescent plasma collected from donors who have recovered from COVID-19 and who have a very high titre of anti-SARS-CoV-2 antibodies reduce the risk of hospitalization or death due to COVID-19 in patients with early symptoms…

Compensatory reading training for people with homonymous visual field defects

This project aims to determine the effectiveness of two reading interventions: Vistra and Rotated Reading. The effects will be investigated on the level of functions, activities and participation. A nuanced view will be provided as to which training…

Endothelial cell loss in pseudophakic patients receiving a Paul glaucoma drainage device with its tube inserted in the anterior versus posterior chamber: a randomized controlled trial

Primary: to determine the loss of corneal endothelial cells after implantation of a Paul GDD with its tube either anterior or posterior of the iris. Secondary: to compare efficacy and safety of both procedures.

Pilot study of the eHealth application *Cancer Patients Better Life Experience*

To compare health-related quality of life, specifically fatigue, in melanoma patients treated with immunotherapy who use or do not use a patient-centered mobile coaching and monitoring system (CAPABLE). We expect that by using the CAPABLE eHealth…

Triple therapy convenience by the use of one or multiple inhaler and digital support in Chronic Obstructive Pulmonary Disease

The primary objective of this study is to investigate if single-inhaler triple therapy (SITT, in this study Trimbow®) is superior to multi-inhaler triple therapy (MITT, in this study Bevespi® and Qvar®) in terms of adherence to inhaled…

Comparing the Baerveldt and Paul glaucoma drainage devices and their effects on the corneal endothelium

To detemine whether the Paul tube induces less damage to the corneal endothelium than the Baerveldt GDD.

Dual hormone closed loop in type 1 diabetes: a randomized trial

To determine the long-term clinical effectiveness of treatment with a dual-hormone (insulin and glucagon) fully closed loop system during 12 months compared to the current most used care and to the currently most advanced technological care.…

A First-In-Human study of 89ZR-DFO-REGN5054 (anti-CD8) Positron Emission Tomography in patients with solid malignancies treated with cemiplimab

The primary objective:To determine the safety and tolerability of 89Zr*DFO*REGN5054 alone and in combination with cemiplimab.Secondary ObjectivesFor Part A:• To characterize the radioactivity pharmacokinetic (PK) profile of 89Zr DFO REGN5054• To…

Prospective, Single-arm Pivotal Study for the Treatment of Subjects with Severe Symptomatic Calcific Aortic Valve Stenosis Using Valvosoft® Non-Invasive Ultrasound Therapy (NIUT)

The objective of the study is to evaluate the safety and performance of a new Non-Invasive Ultrasound Therapy (NIUT) with Valvosoft® in the treatment of CAS.

Conversion of unresponsiveness to immunotherapy by Fecal Microbiota Transplantation in patients with metastatic melanoma and non-melanoma skin cancer: a randomized phase Ib/IIa trial

Primary objective:• To investigate the efficacy, defined as clinical benefit (stable disease (SD), partial response (PR), complete response (CR)) at 12 weeks, confirmed on a second scan after 4 weeks, of an FMT-intervention with responder and non-…