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OUTER SPACE-2: a randomised study on inhaler treatment adherence using a smart spacer in adults with asthma

Primary objective:To assess the overall feasibility of undertaking a definitive randomized controlled trial on the effects of tailored inhaler education by the GP/nurse supported by a smart spacer, in primary care treated adults with asthma.…

Treatment of posttraumatic anger: A study into the feasibility and acceptability of a research protocol investigating an EMDR-based intervention directed at reducing trauma related anger symptoms in forensic outpatients*

Objective: The Directed Anger Protocol (DAP) is an EMDR-based treatment for anger symptoms and revenge urges. Although professionals working with the DAP express positive results in lowering anger symptoms and revenge urges, no quantitative research…

Personalized microbial substrates to prevent type 2 diabetes

In this project we intends to study the therapeutic potential of a personalized fibre mixture in individuals at high risk of developing T2DM, and aims to address the following key objectives: 1. To investigate whether a mixture of fermentable…

Macrophages and monocytes in uncomplicated pregnancy and fetal growth restriction

The goal of this study is to obtain insight into possible differences in macrophage and monocyte populations in uncomplicated pregnancies and pregnancies complicated by FGR.

Better control and treatment of Atopic Dermatitis disease by exploring the universe of microenvironment imposed tissue signatures and their correlates in liquid biopsies

To collect prospective clinical and molecular data on the phenotypical characteristics of patients with atopic dermatitis (AD) receiving standard care targeted systemic treatment.

Prostaglandin E metabolites in urine as a marker for disease activity in colitis ulcerosa. A substitute for calprotectin in faeces?

The objective is to investigate the relation between the concentration of PGE-MUM in urine and disease activity in patients with colitis ulcerosa. PGE-MUM is analyses in urinary 24 hr collection sample and a sample of each urinary portion urinated…

Studying respiratory infections and colonisation in children using daily minimally-invasive nasal sampling

Primary: Associate acquisition of pneumococcal colonisation with levels of pre-existing polysaccharide specific memory B cells. Secondary: a) To validate the use of synthetic absorptive matrices (SAM) for detection of other (non-pneumococcal)…

A randomized prospective clinical trial comparing OsteoActivator-P coated membranes vs Collagen Membrane-P uncoated for accelerated localized alveolar ridge preservation.

Collagen barrier membranes are widely used for ridge preservation applications. Once an extraction socket is filled with a bone filler and covered by a collagen membrane, guided bone regeneration (GBR) is observed due to the barrier function of the…

Fecal microbiota transplantation for improved Fructose catabolism and Insulin sensiTivity In patients with metabolic syndrome : the FFIT study

We would like to investigate if use of donor FMT enriched desulfovibrio bacterial strains has a beneficial effect on gut microbiota diversity and subsequent improvement of (diet derived) fructose catabolism and insulin sensitivity in patients with…

VITAMin Insufficiency in esophagogastric Neoplasms

To identify which micronutrient deficiencies are most common after surgery for esophagogastric neoplasms and to observe the effect of supplementation.

Improving patient care through early and objective detection of delirium for geriatric trauma patients in a trauma geriatric center

To quantify the impact of the use of DeltaScan on patient outcome (duration of admission) in patients with high risk of delirium compared to the currently used delirium screening tools.

GAG-therapy Efficacy Trial Solution for Bladder pain syndrome/ Interstitial cystitis

Main objective is to determine short and long term efficacy of GAG therapy (bladder instillations) for people with BPS-IC H+ as compared to placebo treatment on dominant symptoms such as pain. Secondary objectives are to determine the 1) cost-…

PARADIGM - PARAvalvular leak closure with the Amplatzer Valvular Plug occluDer for Interventional transcatheter closure for PVL with surgical bioloGical and Mechanical heart valve

The rationale for conducting the PARADIGM study is to evaluate the safety and effectiveness of the AVP III for closure of PVLs. Until recently, current treatment in the US and OUS included off-label use of various occluder devices. The study will…

A prospective, multicenter, randomized, parallel-group controlled trial to compare conservative versus surgical treatment of foot drop in peroneal nerve entrapment.

The primary research question of the trial is to assess whether foot drop, caused by peroneal nerve entrapment in adult patients* recovers better within 9 months after decompressive surgery compared to prolonged standard conservative treatment. *…

Image-guided surgery for inguinal sentinel node removal

Inguinal removal of sentinel nodes (SN) is a routine procedure for vulvar cancer, but despite using blue dye and injecting a radioactive tracer, finding the SN can be very challenging in some patients. In this study, we will investigate the…

Primary care decision rule for chest pain using the Marburg heart score rule and troponin point of care test

To determine the effectiveness of a decision rule compared to the usual care of GP*s for patients presenting with non-traumatic chest pain in primary care.

The face of neuromuscular dysfunction: artificial intelligence for the analysis of video data of facial movement, with a focus on Myasthenia Gravis

Primary objectives: To determine and compare the diagnostic yield of two different methods (FaceReader technology and a deep learning model specifically developed for video data) to analyse facial weakness from video recordings (04:00m) with…

Assessment of the Axone micro quadripolar lead for enhanced cardiac resynchronization therapy.

Assessment of the Axone micro quadripolar electrode for enhanced cardiac resynchronization therapy.A clinical study designed to obain the CE-mark.This new, quadripolar micro electrode allows for easier placement of the left ventricular lead,…

Polyethylene Wear of the N2Vac and X3 insert in the Triathlon Total Knee Prosthesis: 10 years follow up of a prospective Randomized Single Centre RSA study

The primary objective is to assess the in vivo wear of the two randomized polyethylene insert types N2Vac and X3 10 years after surgery. The secondary objective is to assess the migration and long-term survival of the Triathlon CS Peri-Apatite…

COvid-19 vaccination and Biomarkers in cirrhosis And post-Liver Transplantation

The primary objective of this observational study is:- to determine if patients with Chronic Liver Disease (CLD) mount comparable humoral immune responses to healthy controls at 8-months following SARS-CoV-2 vaccination.Secondary objectives of this…