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IBIS: A single-centre, phase II study to evaluate the safety, tolerability and pharmacokinetics of 2-IminoBiotin in acute Ischemic Stroke due to large vessel occlusion

This study will be a prospective, placebo controlled, randomised phase 2 single centre study with the primary objective to evaluate the safety and tolerability of 2-IB when administered to patients with AIS due to LVO, treated with IVT and/or EVT.…

A Prospective, Randomized, Controlled Trial to Assess the Management of Moderate Aortic Stenosis by Clinical Surveillance or Transcatheter Aortic Valve Replacement

To establish the safety and effectiveness of the Edwards SAPIEN 3/ SAPIEN 3 Ultra Transcatheter Heart Valve (THV) in subjects with moderate, calcific aortic stenosis (AS)

Additional effect of hydrolysed collagen/vitamin C in exercise treatment for Patellar Tendinopathy (Jumper*s knee); a randomized controlled trial

The primary aim of this RCT is to evaluate whether the use of oral supplementation of hydrolysed collagen/vitamin C in addition to usual care (education, load management and PTLE) is superior to usual care and placebo on VISA-P score after 24 weeks…

The influence of a pain education program on pain perception and psychosocial functioning in
patients with complex regional pain syndrome

1. Mapping the effects of pain education on pain perception and psychosocial functioning of patients with CRPS.2. Further optimize the quality of care for patients with CRPS by further exploring the possibilities of a pain education program.

ENERGIZE IBD - The effect of intensive physical exercise on fatigue and quality of life in patients with quiescent inflammatory bowel disease: A randomized controlled trial

Primary Objective:To assess the effect of a 12-week moderate-vigorous intensity exercise intervention in fatigued IBD patients with quiescent disease on fatigue and health-related quality of life (HRQoL) (short term, measured at 3 months).Secondary…

Stereotactic Arrhythmia Radiotherapy in the Netherlands no. 2

To confirm our STARNL-1 pilot efficacy and safety data in a larger cohort and obtain insights in the mechanism of action by evaluating electro-anatomical alterations of stereotactic arrhythmia radiotherapy in patients with therapy refractory…

Evaluation of a Compensatory Brain Game supporting Goal Management Training intervention targeting executive function after Acquired Brain Injury using single-case experimental design methodology

The primary objective of this study is to assess whether the use of a compensatory brain game supported GMT treatment could be of interest in people with EF deficits after ABI, to improve goal achievement, their executive function performance during…

Percutaneous intratumoural holmium microspheres brachytherapy for patients with pancreatic cancer;
a single centre, prospective safety and feasibility study

To test the feasibility and safety of minimally invasive CT-guided percutaneous holmium-166 microsphere brachytherapy in patients suffering from irresectable pancreatic cancer.

Towards Precision Medicine for Diabetes in Pregnancy

In the present study, we propose to investigate the efficacy of pharmacological treatment of GDM (using metformin) by the pathophysiological cause of hyperglycemia, namely reduced insulin sensitivity or reduced insulin secretion. Primary Objective:…

EvaLuating negAtive pressUre wound theRapy in brEast coNserving surgery - the LAUREN pilot study

The primary objective of this trial is to compare the number of postoperative wound complications in patients with and without negative pressure therapy after breast conserving surgery in the first three months after surgery. Wound complications…

An Open-Label, Single-Arm, Phase 2 Study to Evaluate the Safety, Pharmacokinetics, and Biologic Activity of Pegcetacoplan in Pediatric Patients with Paroxysmal Nocturnal Hemoglobinuria

The objectives of the study are to assess safety and tolerability, pharmacokinetics (PK), and biological activity (including efficacy and pharmacodynamics [PD]) of multiple subcutaneous doses of pegcetacoplan in pediatric patients with paroxysmal…

Improving therapeutic ratio with hypofractionated stereotactic radiotherapy for brain metastases.

To determine if the incidence of adverse local events (local failure or radionecrosis) can be reduced with more than 20% using fSRT versus SRT in one or three fractions.

A randomized controlled trial on the visual function after bilateral implantation of two novel Extended Depth-of-Focus intraocular lenses.

The primary objective of this study is to compare the binocular uncorrected intermediate visual acuity (UIVA) at 66 cm under photopic conditions 3 months postoperatively, in a series of patients bilaterally implanted with the Acunex® Vario IOL…