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Climb Every Mountain

To study prevalence and consequences of cognitive, psychological, social and functional decline in elderly breast cancer patients, in comparison to a population elderly without breast cancer.

PreCARA: Preconception Counselling in Active Rheumatoid Artritis and other chronic inflammatory arthritides;
Preconception counselling for women with rheumatoid arthritis (RA) or another chronic inflammatory arthritis and a pregnancy wish, which is evaluated in a prospective observational study monitoring pregnancy, delivery, postpartum period of the mother, and (growth) parameters of the child.

In the present study we will evaluate the standardized care protocol developed in our outpatient clinic, intended to guide counselling for medication use prior to pregnancy. This protocol guides treatment decisions based on disease activity,…

Assessing and predicting functional and quality of life-related outcomes of islet and pancreatic transplantation in patients with type 1 diabetes mellitus

There are two objectives for this study: first, to find specific serum beta cell damage markers that can serve as a clinical predictive tool for beta cell allograft loss. Second, to compare quality of life and diabetes-related outcomes in patients…

A proof of concept study for [18F]FB-IL2 PET imaging of infiltrating T cells after renal transplantation; a diagnostic tool for acute rejection

To investigate if [18F]FB-IL2 PET/CT is able to detect acute allograft rejection in kidney transplantation patients.

Open-Label, Multi-Center, Randomized Study of Anti-CCR4 Monoclonal Antibody KW 0761 (mogamulizumab) Versus Vorinostat in Subjects with Previously Treated Cutaneous T-Cell Lymphoma (CTCL)

The main purpose of this study is to determine if KW-0761, an investigational drug will work against cutaneous T-cell lymphoma (CTCL) that has failed to respond to other treatments, and to evaluate its side effects. An investigational drug is one…

The role of regulatory T cells in the pathogenesis of sarcoidosis.

Our primary objective is to identify which intrinsic defect in Tregs is crucial for sarcoidosis pathology. To this end we will examine the genetic and functional properties of Tregs in the peripheral blood and at the site of disease, i.e. the lung…

Intrathoracic versus Cervical ANastomosis after minimally invasive esophagectomy for esophageal cancer: a randomized controlled trial

The ICAN research question is: What is the effectiveness of an intrathoracic compared to a cervical esophagogastric anastomosis after (hybrid) minimally invasive esophagectomy in terms of anastomotic leakage, morbidity, quality of life and costs?

Breast conserving therapy using Accelerated Partial Breast Irradiation (APBI) in elderly patients: a feasibility study

Confirm favorable treatment results of international studies.Relate (loco regional) tumor control, side effects and (inter current) death to geriatric questionnaires/condition, co-morbidity and usage of medication.

Surgical Replacement and Transcatheter Aortic Valve Implantation Trial 10 Year Follow-up

The objective of this trial is to characterize annually the safety and durability data through 10 years in a subset of subjects randomized in the SURTAVI trial.

Acute anterior cruciate ligament rupture: RecOnsTruction Or Repair?

Primary goal: Investigate the hypothesis that suture repair of a ruptured vkb, combined with a dynamic intraligamentary stabilization and microfracture of the femoral notch, results in at least equal effectiveness compared with an ACL reconstruction…

The use of Prevena Incision Management System on clean closed sternal midline incisions in subjects at high risk for surgical site occurrences.

The objective of the study is to assess the performance of topical negative pressure therapy application with Prevena* Incision Management System (IMS) versus standard conventional wound therapy (SCWT) on closed median sternal incisions in patients…

The long-term follow-up interferon-α treatment for chronic hepatitis B infection

To study the long-term effects of interferon-α treatment for chronic hepatitis B patients infection.

Unravelling aetiology and risk factors in patients with a Bicuspid Aortic Valves * study of clinical outcome and genetics

The BAV study is a clinical and genetic study to unravel biomarker and imaging predictors of adverse outcome and to explore the pathogenetic basis of bicuspid aortic valves and it*s associated pathologies. We will also deliver insights in the…

The neural signature of self-concept development in adolescence in relation to romantic relations and sexuality in youth

Original study:The goal of this study is to have a theoretically based understanding of how sub processes of self-concept development emerge in relation to each other. The primary objective is to test a neuroscientific model of self-concept…

Unravelling intestinal inflammation: from Celiac Disease genotype to autoimmunity.

The primary aim of the current proposal is to get a better understanding of how CeD risk genes contribute to disease aetiology. To achieve this, we will apply a holistic approach in which we will study the behaviour of immune cells and the…

Toward a More Effective Treatment of Obesity: A RCT on Emotional Eating Reduction by Dialectical Behaviour Therapy

This study assesses the effectiveness of DBT in comparison to the effectiveness of the treatment as usual, the (standard) cognitive behavioural therapy, by using a randomised controlled design situated in the eating disorder and obesity unit of…

Repeat CT scans to determine shape variation during radiotherapy of the esophagus in esophageal cancer patients: ReShape study

Primary objective: to investigate the intra- and interfraction motility of the CTV (the primary tumor as well as any affected celiac lymph nodes) in radiotherapy for esophageal cancer, and to determine adequate CTV-ITV margins.Secondary objective:…

European Non-invasive Trisomy Evaluation (EU-NITE Study): Evaluation of a targeted analysis of cell free fetal DNA in maternal blood for prenatal diagnosis of fetal trisomies.

our primary aim is to validate a targeted analysis of circulating DNA in maternal blood by assessing the diagnostic accuracy for fetal trisomy 21. In addition, test characteristics for fetal trisomy 18 detection will be evaluated.

Intracranial pressure variability in migraine;
A prospective study to evaluate changes in intracranial pressure during different migraine attack phases

ObjectivesOur main hypothesis is that ICP shows a dynamic profile over the course of different attack phases in migraine. Therefore, we aim to detect dynamic changes in ICP in relation to different phases of the migraine attack. In concreto, the…

Effects of bosentan in a homogeneous population of SSc subjects with a predefined restriction of blood flow in the hands

The primary objectives are:- To demonstrate the relationship of blood flow in the hands and the extent of digital ulcera in patients with systemic scleroderma;- Evaluate the effect of bosentan on the blood flow in the hands from baseline to 12 weeks…