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ARTEMIS: A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multi-Center, Parallel-Group, Event-Driven Study to Evaluate the Efficacy and Safety of Ambrisentan in Subjects with Early Idiopathic Pulmonary Fibrosis (IPF).

The primary objective of this study is to determine if ambrisentan is effective in delaying disease progression and death in subjects with IPF.Secondary objectives include evaluation of the safety and effect of ambrisentan on development of…

DISCOVER: Dutch Iliac Stent trial: COVERed balloon-expandable versus uncovered balloon-expandable stents. A prospective, randomized, controlled, triple-blind, multi-center trial comparing PTFE-covered balloon-expandable stents versus uncovered balloon-expandable stents in patients with advanced occlusive disease of the common iliac artery in terms of morphologic, clinical, and hemodynamic outcome after a 2-year follow-up.

Our primary objective is to assess the absence of binary restenosis rate, the reocclusion rate and target-lesion revascularization rate of endovascular treatment of advanced atherosclerotic lesions of the common iliac artery with a balloon…

PILOT
Conservative treatment of midclavicular fractures with Kinesio® clavicular tape and sling vs sling

Goal of our study is to compare conservative treatment of mid-shaft clavicle fracture with Kinesio® clavicle tape combined with sling to conservative treatment with sling. Goal of our Pilot-studie is;Investorise if the VAS-score, the DASH…

A Phase 3, Randomized, Double-Blind, Multicenter Trial Comparing Orteronel (TAK-700) Plus Prednisone With Placebo Plus Prednisone in Patients With Chemotherapy-Naïve Metastatic Castration-Resistant Prostate Cancer

To determine if orteronel plus prednisone improves radiographic progression-freesurvival (rPFS)To determine if orteronel plus prednisone improves overall survival (OS)

A phase I, randomised, double-blind, placebo-controlled study in patients with amyotrophic lateral sclerosis to further assess the safety and tolerability of intracerebroventricular administration of sNN0029 infusion solution.

The objective of the trial is to assess the safety and tolerability of i.c.v. administration of sNN0029 infusion solution at a dose of 4 µg per day delivered via a Medtronic SynchroMed® II Infusion System.

The effect of cognitive bias modification of interpretive bias in the treatment of dental phobia

Investigation of the effect of interpretive bias modification on anxiety levels in dental phobia. If CBM-I indeed has positive effects in the treatment of dental phobia, it could be integrated in the treatment-as-usual as an additional intervention…

The value of Platelet-Rich Plasma injections in the treatment of the jumper's knee: a double-blind randomised trial

There is a double study objective:- First the effects of a PRP-injection in the treatment of the jumper's knee in comparison with the effects of a placebo injection - Second the effects of a PRP-injection in comparison with the effects of an…

Embryo selection using time-lapse monitoring in IVF and ICSI patients

Does embryo selection using time-lapse monitoring (TLM) with Eeva (Early Embryo Viability Assessment) improve the (cumulative) ongoing pregnancy rate after IVF & ICSI treatments?

Trial NL77388.056.21

Publication withdrawn by sponsor

Task-induced sensitized brain circuits during rTMS in major depressive disorder

The objective of this study is to detect whether stimulation during task induced activation of brainnetworks leads to a higher efficacy of rTMS and other neurobiological changes.

Excitability Modeling And Correction of Hyperactive Brain Networks in Alzheimer*s disease

The overall objective is to perform simulations in a computer model of the human brain to map out the optimal parameters for non-invasive brain stimulation in AD. Simulations will be performed in both general and personalised models, the latter…

A Phase 3, Randomized, Double-Blind, Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Subjects with Active Psoriatic Arthritis Who Have a History of Inadequate Response to at Least One Non-Biologic Disease Modifying Anti-Rheumatic Drug (DMARD) - SELECT - PsA 1

This is a Phase 3 multicenter study that includes two periods. Period 1 is designed to compare the safety, tolerability, and efficacy of upadacitinib low dose once daily (QD) and high dose B QD versus placebo and versus adalimumab every other week (…