22 results
1. Implementation of a point-of-care fully automated analysis of neutrophils in the emergency department trauma bay in monotrauma geriatric hip fracture patients. 2. To determine if patients who develop infectious complications demonstrate decreased…
The aim is to provide enough evidence through RifRam model analysis, physical tests and clinical study of 10 patients that our new type of personalized mandibular implant is safe to use, resulting in significantly fewer complications and can be…
To investigate whether treating children with high refractive errors at age one with glasses prevents the development of amblyopia.
The main objective is to assess the effects of environmental pollution risk factors on bone health in-vivo in patients with osteoporotic fractures. We hypothesize that higher levels of heavy metals, particularly lead, are detectable in some patients…
To investigate whether proton MRI can be used to visualize disease and to study lung mechanics. This new information might give us new insights into the pathophysiology of asthma.
In this study we will assess the applicability of a digital intake in the Dutch colorectal cancer screening program in participants with a positive FIT who are referred for colonoscopy.
To investigate brain morphology and brain activation in response to odor stimulation in participants with a normal smelling ability.
The overall aim of the study is to gain more insight in as well as understand and map the pharmacokinetics of tacrolimus during pregnancy. Therefore, we will study tacrolimus concentrations in maternal whole blood (routine care) and via area under…
Primary Objective: The primary objective of this study is to investigate the prevalence EPI in the advanced HF population Secondary Objectives: • To determine the association between exocrine pancreatic function and markers of HF• To determine the…
Determine the difference in mitoPO2 in between the cannulated and non-cannulated and the difference in DLS red blood cell velocity (RBV) between the two legs, in patients undergoing a cardiopulmonary bypass (CPB) MICS with standard cannulation.
Primary Objective (PHASE 1: feasibility study): - Determine whether measurements of glycocalyx and other microvascular parameters using SDF imaging (on the conjunctiva and sublingually) are feasible in aSAH patients during a period of 2 weeks post-…
The objective of this clinical study is to evaluate the impact of Multipoint Pacing (MPP) and SyncAV programming on ventricular electrical activation time and activation sequence using noninvasive electrocardiographic imaging (ECGi) in patients…
Primary Objectives: Safety Assessments: Effect of Administration of Relacorilant on: • Incidence of TEAEs (assessed monthly): TEAEs, SAEs, treatment-related TEAEs, TEAEs leading to early discontinuation of study treatment• Clinical laboratory tests…
Primary:To assess the effect of bilateral treatment with AAV5-hRKp.RPGR on functional vision as measured by vision-guided mobility assessment.Secondary:To assess changes after treatment administration in retinal function, functional vision, visual…
- To compare the pressure signals measured by the different available pressure guidewires, specifically the FFR value- To assess the occurrence of hydrostatic errors when using sensor-tipped wires- To assess the occurrence of drift between the…
The objectives of this study are to determine:• The safety and tolerability of trimetazidine in patients with ALS/MND• The change from baseline in oxidative stress markers in patients with ALS/MND after the initiation of trimetazidine• The change…
Objective: to evaluate the effects of MOF in comparison to placebo on exercise blood pressure, endothelial function, inflammatory and redox status in healthy volunteers. In addition, the study will aim to assess the impact of MOF supplementation on…
Primary ObjectiveTo validate biomarkers of response to bariatric surgery and to develop algorithms, which combine these variables, to predict individual responses. Secondary Objectives* To establish the predictive value of selected preoperative…
Primary:The primary objective of this open-label, LTFU study is to evaluate the long-term safety and tolerability of sotatercept when added to background PAH therapy in adult participants with PAH.Secondary:The secondary objective is to follow…
In this study we clinically validate if host cell DNA methylation markers can predict (non-)regression of HGAIN, thus determining the need of immediate treatment versus active surveillance and the safety of withholding treatment. This could prevent…