1418 results
The aim of this project is to assess whether 4D-CTA can generate 3D cranial image data sets with sufficient spatial and temporal resolution to enable its use as a diagnostic tool in cerebrovascular pathology and physiology such as arteriovenous…
Part I of the study: I) to determine if one or a batch of aging marker(s) is/are associated with the presence of objectively diagnosed COPD related co-morbidity (muscle wasting, osteoporosis, cardiovascular risk, glucose intolerance, renal failure,…
1. Evaluation of gene-expression profiles of endometria of PCOS women compared to normal ovulatory women2. Identify genes and pathways which contribute to a high rate of miscarriages of PCOS women3. Identify genes and pathways related to the high…
Objective: The main objective is to establish the strength of the relationship between improvements in dyspnea and health related Quality of Life (HR-QoL) with the decrease in hyperinflation during the resolution of a COPD exacerbation in the…
The present research protocol aims at the development and implementation of a valid self-report instrument for suicidality amongadolescents. The instrument needs to be invariant for ethnicity and needs to register fluctuations in suicide risk and…
The first aim of this study is to determine the prevalence of cognitive impairment in COPD patients compared with persons without COPD. The second aim is to study the clinical characteristics of COPD patients with cognitive impairment. The third aim…
1. To construct a Dutch multicenter prospective biorepository for validation of biomarker and imaging products.2. To provide a Medical Technology Assessment (MTA) of newly developed biomarkers, contrast enhanced ultrasound and multimodality MR Iin…
Obtain information regarding the movement abilities and muscle strength in persons with several neuromuscular diseases, which can be used to develop a motion controlles arm suport for daily use and training of arm function.
Main objective is to investigate whether the use of a modified CellSearch enrichment for the enumeration of pleural effusion tumor cells (PTCs) is able to increase sensitivity of pleural effusion evaluation in MPM, as compared to standard…
ObjectiveThe main goal of this investigation is to evaluate the thyroid hormone response in patients with TMNG and control subjects in response to various pharmacological and physiological stimuli, administered according to the dynamic exposure test…
The primary objective of the study is to determine sensitivity, specificity, positive and negative predictive value of the enzyme analyses (myeloperoxidase, human neutrophil elastase and lysozyme) with wound biopsies as the gold standard.…
The aim of this study is to investigate immune response to pneumococcal vaccination in patients after community acquired pneumonia with S. pneumoniae compared to pneumonia patients with another pathogen.
Our primary objective is to determine the incidence of EPS after kidney transplantation in patients previously treated by PD. We hypothesize that there is an increasing incidence of symptomatic and asymptomatic EPS after kidney transplantation.
What is the cost-effectiveness of referral to MRI compared to usual care by the general practitioner in patients with persistent traumatic knee complaints.
1- to describe the presence and severity of hemiplegic CP on the basis of neonatal MRI findings and correlate the involvement of different structures (basal ganglia, posterior limb of the internal capsule and hemisphere) with the size of the lesion2…
1. Feasibility and reproducibility of transcutaneous (tc) dEMG on premature neonates. - Are the signal quality (heart rate and respiratory rate), bradycardias and apneas similar to the current impedance monitoring2. Can we differentiate between…
Estimate the maximum tolerated dose (MTD) of AEB071 (dose escalation) and characterize the safety and tolerability of the MTD or recommended Phase 2 dose of AEB071 in patients with metastatic uveal melanoma (dose expansion).
In the future, the determination of CTCs and ctDNA in the CSF could be a new quantitative method for the anti-tumor response assessment of systemic or intrathecal therapy (as opposed to CSF cytology, which is subjective and not a quantitative method…
The aim of this study is to retrieve extra measurements by Nexfin and laboratory testing in the per- and postoperative period. Can the use of Nexfin contribute in the generation of meaningful data to get an idea of the hemodynamic state of the…
The primary objective is to study 1/ cross-sectionally the prevalence of bone erosions and 2/ longitudinally the progression of bone erosions in the 2nd and 3rd proximal interphalangeal (PIP) joints and metacarpophalangeal (MCP) joints of the hands…