Search for a trial

Effects of VERApamil versus metoprolol to prevent progression from Paroxysmal to persistent Atrial Fibrillation

We hypothesize that verapamil reduces progression from paroxysmal to persistent AF, improves rate control, exercise tolerance and quality of life and reduces costs compared to metoprolol.

NERVE GROWTH FACTOR * MEASUREMENT METHOD VALIDATION STUDY: DRIED BLOOD SPOT ANALYSIS AND SALIVA SAMPLE TESTING COMPARED TO VENOUS SERUM CONCENTRATION

To answer the question if dried blood spot (DBS) analysis and saliva hormone testing are reliable methods to determine the concentration of NGF-ß in healthy subjects.

The sIL-2R level in patients referred with a suspicion of Complex Regional Pain Syndrome.
Comparison between those who are diagnosed with CRPS and those who are not.

To compare the level of the sIL-2R between patients who are referred to the Center for Pain Medicine with a suspicion of CRPS but do not fulfill the new IASP Clinical Diagnostic Criteria for CRPS and those who do fulfill the new IASP Clinical…

PILOT STUDY PROTOCOL: LOW-PRESSURE PNEUMOPERITONEUM WITH DEEP NEUROMUSCULAR BLOCKADE IN BARIATRIC SURGERY TO REDUCE POSTOPERATIVE PAIN

Aim of this pilot study is to determine which intervention groups are feasible in a larger trial which aims to a compare postoperative pain and complication rates in moderate versus deep neuromuscular blockade, and normal versus low intra-abdominal…

Study on intracranial meningioma using PET ligand investigation during follow-up over years [SIMPLIFY]

Compare the combined MRI/MET-PET report to the MRI-only report.

Implementing Self management using eHealth for monitoring and management after Catheter ablation in the treatment of Atrial fibrillatioN.
A study on the diagnostic accuracy and the effects of eHealth rhythm monitoring on patient related outcomes, clinical management and health outcomes.

Optimise post PVI management using ambulant continuous patient-driven eHealth monitoring after catheter ablation in the treatment of atrial fibrillation.Primary Objective:1) Determine the effect of eHealth on clinical management, outcomes and…

Concept and Feasibility Investigation of Planning to Live and Easy Echo for Mitral Interventions

The purpose of Part 1 of the research is to look at the usability and accuracy of the automatically determined CT visualizations and measurements.The purpose of Part 2 of the study is to determine whether the use of the combined information provides…

Blind versus Ultrasound-guided Radius Reduction STudy

This multicentre randomised controlled trial aims to investigate whether PoCUS can be used as an adjunct to improve first attempt success rate in closed reductions of displaced distal radial fractures in adults in the ED.

First in-human study on the Safety, Tolerability and Efficacy of the Aqua Medical focal vapor ablation system, for the eradication of Barrett*s Esophagus

The aim of the current study is to assess the feasibility, safety and efficacy of the Steam ablation System for eradication of small BE areas

Cortical activation patterns measured with functional near-infrared spectroscopy (fNIRS) during freezing of gait triggered by turning and passing doorways in Parkinson's disease.

The main objective of this study is to identify cortical brain regions that show significant altered fNIRS activity during FOG in patients with PD. This is accomplished by considering four secondary objectives. First, we compare the cortical…

A phase 1a/1b/2 study to assess the safety, tolerability and pharmacokinetics of OTL78, a PSMA-targeted fluorescent agent, for the intraoperative imaging of prostate cancer

Part A: healthy volunteers (n=up to 15)Primary/safety objective: - To assess the safety, tolerability and pharmacokinetics of a single IV dosage of OTL78 Secondary objective: - To assess the pharmacodynamics of OTL78 by measuring the temporal…

Transcutaneous vagus nerve stimulation to enhance exposure efficacy in public speaking anxiety

To investigate whether augmentation of one standardized exposure session for SAD with tVNS results in lower fear compared to expsoure plus sham. We also aim to test if tVNS yields enhanced retention of extinction memory, during a second exposure…

Evaluation of a new powered knee prosthesis (Reboocon IntelLeg Knee)

The primary objective is to evaluate the added value of the IntelLeg Knee on the execution of activities of daily living for individuals with a transfemoral amputation when compared to the use of an auto-adaptive or mechanical (non-powered)…

Advanced Image Supported Left Ventricular Lead Placement in Cardiac Resynchronization Therapy
(ADVISE-CRT II trial)

To determine the safety, feasibility and efficacy of targeted left ventricular lead placement with CRT procedures, using the CARTBox software.

Routine Microcirculation Measurements in Intensive Care Unit Patients and Validation by PiCCO Technology. ROUMI-study

With this project, we aim to validate Cytocam-IDF imaging as a routine monitoring tool in critically ill patients. To this end, we will compare Cytocam-IDF imaging to an invasive hemodynamic monitorization tool (PiCCO) in terms of comparability and…

Safety and efficacy of the addition of IMM-101 Heat-Killed Whole Cell Mycobacterium obuense to standard stereotactic radiotherapy in locally advanced pancreatic cancer patients (LAPC-2 trial).

This phase I/II study consists of 2 subsequent study parts. In the phase I part we will investigate the safety of combining IMM-101 administration with SBRT in 20 patients with locally advanced pancreatic cancer who have completed at least 4 cycles…

A randomized, double-blind, two-way cross-over study to determine the effects of levetiracetam on corticospinal excitability in patients with treatment-controlled epilepsy, as measured by single and paired pulse TMS-EMG and TMS-EEG

- To evaluate effects of levetiracetam 2000 mg on single and paired pulse TMS-EMG and TMS-EEG in patients with epilepsy treated with mono-therapy levetiracetam, when compared to placebo (levetiracetam trough concentrations). - To evaluatethe effects…

A study to evaluate the sensitivity of muscle velocity recovery cycles to determine changes in muscle excitability, by evaluating pharmacological effects in healthy subjects, and by comparing healthy subjects with myasthenia gravis patients

Primary ObjectivesPart A- To evaluate the sensitivity of muscle velocity recovery cycles (MVRCs) to determine effects of ischemia on muscle membrane potentials- To evaluate the sensitivity of MVRCs to determine effects of mexiletine on muscle…

Wearables and challenging behaviour in geriatric psychiatry

The purpose of this research is to determine the usability of a wearable regarding the care of people with dementia showing challenging behaviour in a nursing home (geriatric psychiatry department). The relationship between biomedical data and…

Low-field MRI visualisation of gravity-dependent endograft migration in patients with suspected endoleaks after EVAR (endovascular aneurysm repair)

The objective of this study is to see if the apposition and position of the endograft in the aorta changes between an upright and laying down position of the patient. An upright position with other geometrical parameters than in supine position…