53 results
Answering the question if there are any associations between hormonal status in adolescence on the one hand, and immunological reactivity and pharmacodynamics on the other hand; and if such associations can explain the more rapid deterioration of…
To study the effectiveness of gut-directed hypnotherapy in the treatment of IBS-like symptoms in patients with inflammatory bowel disease.
To study the frequencies and differentiation status of CD4 and CD8 T cell populations (Tnaive, TCM, TEM, TEMRA) in young (18-50) and old (>65) treatment naive metastasized melanoma patients at baseline and after treatment.
Does humoral and/or cellular rejection play a role in recurrent miscarriage of unknown etiology?Can biomarkers of humoral and/or cellular rejection be used for the detection of patients who are likely to suffer a miscarriage in a next pregnancy?
To investigate the time course in which (peri-)implant complications (i.e. inflammation and bone loss around dental implants and implant technical complications) develop and to identify the associations of sleep bruxism with these complications.
To investigate the role of the gut microbiota in the systemic priming of immune effector cells
Primary Objective: 1. Will an exposure to oxygen with a PO2 = 190 kPa lead to changes primarily in DLno compared to DLco?Secondary Objectives: 1. After an exposure to oxygen with a PO2 = 190 kPa for one hour, are the changes primarily located in the…
Do patients with (recent onset, medicated) psychotic disorder (PDM), in persons at ultra high risk for later psychosis (UHR), in patients with schizophrenia who do not use anti-psychotics anymore (PDUM) report higher levels of trait anxiety (…
The aim of our studies is to explain weight gain in individuals based on their geneticpredisposition, and their physiological and behavioral responses to the current obesogenicenvironment and to define personality subtypes, which specify the…
To assess whether changes in insulin sensitivity through dietary interventions affect postprandial bile acid metabolism and kinetics. Secondary objective: to assess TGR5 and FXR mediated pathways in insulin resistant and insulin sensitive states.
RESEARCH QUESTIONS* Is the currently used RNAF protocol for the acute medical care on the Battlefield sufficient.* What recommendation can be made to enhance this protocol, with emphasis on the transfer of information from battle field to second…
The objective for this study is to examine alpha suppression in PTSD and evaluate it as a predictor of treatment outcome. We will first examine if there are differences in alpha suppression PTSD patients (prior to treatment) and the typical…
We plan to compare the costs and effects of both methods.
The general aim of the Generation R Study is to examine environmental and genetic causes that influence growth, development and health during fetal life, childhood and adulthood.The more specific aims of the study are: (1) To describe normal and…
(1) To investigate the rate of glycaemic deterioration in subjects at high-risk of type 2 diabetes and with clinically manifest diabetes.(2) To identify biomarkers that define sub-classes of diabetes and thus enable targeted diabetes prevention or…
The aim of this study is to compare the integrity of the corticospinal tract and cortical reorganization of shoulder girdle muscle representations in chronic stroke patients with and without GHS as well as healthy controls.
Primary objectives:1a. To determine the severity and course of obstructive sleep apnea in children with congenital mandibular hypoplasia (both isolated and syndromal).1b. To determine the growth pattern of the lower face in relation to the upper…
The aim of this research is to contribute to the understanding of the pathophysiology of severe infections, and subsequently providee relevant new insights in the development of new treatment modalities. In the present research proposal we would…
The objective of the current experiment is to validate cognitive- and EEG-diagnostic markers of ADHD-symptoms by studying differences in cognitive task performance between subjects diagnosed ADHD, undiagnosed ADHD subjects showing ADHD symptoms and…
The overall aim of this project is to elucidate the interaction between stress and epileptic seizures in childhood epilepsy. The specific aim of this study is to compare the possible differences in stress hormone regulation, hippocampal function and…