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Intraarticular treatment of osteoarthrits of the hip: A randomized trial of hyaluronic acid (Fermathron S) vs corticosteroids (Depomedrol).

Will the hyaluronic acid injections have impact on pain reduction and functional improvement in patients with osteoarthritis of the hip ?

Flexible versus standard intramedullary rod in Triathlon primary total knee replacement: effects on sagittal contour of the distal femur, implant positioning, functional outcome and sizing

Primary Objective: To compare the standard IM rod with the flexible IM rod in terms of post-operative sagittal contour of the distal femur. Secondary Objective(s):To compare the standard IM rod with the flexible IM rod in terms of post-operative…

Recovery of circadian rhythm of the hypothalamic-pituitary-adrenal axis during glucocorticoid tapering in ANCA-associated vasculitis, a pilot study

The primary aim of this study is to investigate the recovery of the circadian rhythm of the hypothalamic-pituitary-adrenal axis during a glucocorticoid tapering regime. Secondary objectives include the effect of a tapering regime on melatonin rhythm…

Cost-effectiveness of vocational rehabilitation for workers on sick leave due to subacute or chronic musculoskeletal pain

1) For workers on sick leave due to subacute or chronic musculoskeletal pain, is a 40 hours vocational rehabilitation program non-inferior on work participation compared with a 100 hours vocational rehabilitation program? 2) For workers on sick…

Short dental implants (4 mm) in the posterior region of the mandible to support a single crown

The aim of this study to evaluate the clinical performance of short implants (4 mm in length) in the resorbed posterior mandibular region of partially edentulous patients that will be restored with a single crown.

The effects of body weight support, guidance, and gait speed on patterns of muscle activity in the Lokomat, in persons with post stroke hemiparesis and in healthy walkers

a. To establish the effects of (1) body weight support (2) treadmill speed, and (3) level of guidance/ movement support, on the neuromuscular control of the lower extremities in patients with post-stroke hemiparesis, and to determine possible…

Influence of an acidic beverage on the absorption of erlotinib

To determine the influence of the acidic beverage Coca-Cola, concomitantly taken with erlotinib (with or without a PPI), on erlotinib plasma pharmacokinetics compared to erlotinib concomitantly taken with water in cancer patients.

Effect of a Platelet Rich Plasma (PRP) injection on the outcome of chronic lateral epicondylitis.
A double blinded randomized controlled clinical trial.

The effectiveness of PRP treatment in patients suffering from chronic lateral epicondylitis is still ambiguous. Therefore we study PRP treatment in a double blind randomized controlled trial in a homogeny patient population with respect to duration…

A RCT on the effectiveness of Behavioral Activation for Negative Symptoms (BANS) for negative symptoms in schizophrenia

Primary objective of the study is to investigate whether Behavioral Activation for Negative Symptoms (BANS) improves negative symptoms. Secondary objective is to investigate whether effects of BANS on negative symptoms is mediated or moderated by…

Driving performance in patients with idiopathic cervical dystonia; a driving simulator pilot study

To investigate the differences in driving performance and safety between CD patients and healthy controls in a driving simulator. To compare the subjective evaluation of the difficulty of various aspects of the driving task driving in CD patients…

Pilot study evaluating the feasibility of endoscopy guided fiducial marker placement for rectal cancer.

This pilot study will evaluate the feasibility of endoscopic guided placement of gold markers in rectal cancer patients including:- Technical success of fiducial marker placement by (EUS guided) endoscopy- Visibility of fiducial markers on MRI and…

Blended versus face-to-face Cognitive Behavioral Therapy for major depression in specialized mental health care * a pilot randomized controlled trial examining health care efficiency

This pilot cost-effectiveness study will compare blended cognitive behavioral treatment (bCBT) with standard face-to-face CBT (CBTAU) among patients with a diagnosis of major depressive disorder (MDD), who are treated in outpatient specialized…

Randomized Evaluation of short-term DUal anti platelet therapy in patients with acute coronary syndrome treated with the COMBO dual-therapy stEnt

To evaluate safety of 3-months versus standard 12-months of DAPT

Does oral administration of dabigatran etexilate, a direct thrombin inhibitor, achieve clinical significant concentrations of dabigatran and thrombin inhibiting activity in vitreous and subretinal fluid?

To investigate whether oral administration of dabigatran etexilate in patients with a rhegmatogenous retinal detachment leads to clinical significant dabigatran levels and thrombin inhibiting activity in the vitreous and subretinal fluid.

Phase I pharmacological study of continuous and intermittent chronomodulated capecitabine therapy

To determine the maximum tolerated dose (MTD), dose-limiting toxicities (DLTs) and recommended dose (RD) of continuous and intermittent chronomodulated capecitabine.Secondary study objectives are:To determine plasma pharmacokinetics of capecitabine…

Mechanochemical Endovenous ablation (MOCATM) versus radiofrequency ablation (RFA) in the treatment of primary Small Saphenous vein Insufficiency: a multicentre randomized trial

Objective: To evaluate the anatomical success of MOCA versus RFA in treatment of symptomatic insufficient SSV.

Patient Blinded Randomized Clinical Trial comparing two types of mobile bearing unicondylar knee replacement

To assess non inferiority of a Multi Radius design (ACS® unicondylar) compared to a Single Radius design Unicondylar knee implant (Oxford) on clinical outcome using the Oxford Knee Score.

The effectiveness of the POPP-Treatment Program for sexually abused preschoolers: Healing Play as core element in Trauma-Focused Cognitive Behavioral Therapy.

Objective: The main objective is to evaluate the effectiveness of the POPP-treatment program in reduction of severity of post-traumatic stress symptoms for sexually abused preschoolers. Secondary objectives are to evaluate the effectiveness of the…

SOS-training Social skills and Street skills: Improving strength and reducing vulnerability for victimisation: a randomised controlled trial in addicted patients with psychiatric disorders

The goal of this study is obtaining knowledge about the effectiveness of a training that aims to decrease victimisation of dual diagnosis patients.The primairy research question is:- What is the effect of the SOS-training on the frequency of…

Proactive treatment of collateral ventilation in CV-positive emphysema patients
before EBV treatment.

Primary objective: 1. To investigate the feasibility of injecting autologeous blood or blood derived products into the interlobar collateral ventilation channels region to make the target lobe suitable for endobronchial valve treatment.Secondary…