1227 results
The primary objective of this study is to assess whether the CD4+ T cell compartment displays a less pro-inflammatory profile in patients which are supplemented for the SOLAR study with high doses of vitamin D3 when compared to patients which are…
- To educate adolescents about clinical drug studies by involving them as project team members and participants in a class experiment with negligible risk and minimal burden;- To educate adolescents about the effects of a low (*social*) dose of…
The first aim of the study is to investigate whether DCS addition to exposure therapy enhances symptom reduction in PD+AGO. The second objective of the study is to establish the optimal timing of administration of DCS (30 minutes before or directly…
A study to investigate the safety, pharmacokinetics and pharmacodynamics of a new recombinant human factor VIIa in healthy males, compared to Novoseven.
Cholesterol absorption inhibition (%) calculated from plasma concentration vs. time curves from labeled cholesterol, for the PS or PSE containing products, compared to a control product without PS or PSE.
The purpose of this study is to evaluate the safety and performance of Hydros and Hydros with triamcinolone acetonide, (Hydros TA) for treatment of pain from osteoarthritis of the knee, in patients who have failed to respond adequately to…
The primary objective of this study is to determine the glycaemic index of palm sugar in healthy adults
The objectives of this exploratory trial are:1. To measure the pharmacodynamic (PD) effect on parameters derived from 24-hpH/impedance (MII) monitoring,2. To explore the effect on symptoms,3. To evaluate the safety and tolerabilityof treatment with…
To establish if and how the endocannabinoid system is involved in ADHD and related symptoms. This will be investigated by assessing the acute effects of a cannabinoid agonist (THC) on brain function related to ADHD and ADHD symptoms.
The main objective of the present protocol is to investigate to what extent oxytocin modulates specific aspects of approach behavior and action control in healthy volunteersResults from this study shall give rise to designing a future study on the…
Primary Objective: to investigate the effect of rosuvastatin 20 mg qd on subsequent immune activation markers in treatment-naïve HIV-patients: circulating LPS (LAL assay), TLR mRNA expression in whole blood, circulating IL-6, D-dimer, hsCRP, CD38…
1. Primary Objectives of the study: The primary objectives of this study are to evaluate the efficacy and safety of 2 SC dosing tiers of ustekinumab in the treatment of adolescent subjects * 12 to < 18 years of age with moderate to severe…
The objective of this study is to evaluate the safety and efficacy of two doses of FFNS (110 mcg once daily and 110 mcg twice daily) compared to placebo as monotherapy in the treatment of adult and adolescent subjects 12 years of age and older with…
Probleemstelling: Er is geen duidelijkheid of rTMS, toegepast binnen het reguliere revalidatieprogramma na een beroerte, leidt tot een extra verbetering in motorische herstel volgens de klinimetrie zoals gehanteerd binnen de in Nederland gebruikte…
Research into the effects of memory training on behavior and cognitive performance of ADHD children.
Studying and comparing the short and long-term effects of two different memory trainings on the behavior and cognitive performance of children with ADHD within a controled design. Training excersizes are dereived from a published training from…
Investigate the effects of levocetirizine, diphenhydramine and placebo on cognitive and psychomotor functioning during controlled simulated diving in a recompression chamber in professional navy divers at 10 mt (2 bar) and 30 mt (4 bar).
The purpose of the study is to investigate the effects of oxyntomodulin, a substance that is naturally produced in your body, when you fast (not eat for a period of time) and when you are given a glucose (sugar water) infusion.
The (cost) effectiveness of an intervention on energy balance related behaviours and work engagement
The study aims to develop an intervention to improve workers' energy balance related lifestyle behaviours (EBRB) to prevent overweight and to improve work engagement and subsequently evaluate the intervention developed.
Primary:* To evaluate safety and tolerability.* To evaluate antiviral activity.Secondary:* To evaluate plasma and urine PK.* To evaluate the effect of food on the PK of the study drug.
The primary objective of this proof of principle study is to determine the effect of levosimendan on the strength and endurance of the diaphragm in healthy subjects. The secondary objective is to gain insight in the neural activation and efficiency…