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Chronic Cerebrospinal Venous Insufficiency and Multiple Sclerosis: An age and sex-matched controlled Study.

The main point of this study is to detect in a controlled fashion if there is a relationship between CCSVI and MS. We focus on 5 parameters indicative of CCSVI: 1-reflux in the internal jugular vein (IJV) or in the vertebral vein (VV), or both with…

A 24-week, multicenter, international, randomized (1:1), parallel-group, open-label, comparative study of insulin glargine versus liraglutide in insulin-naïve patients with Type 2 diabetes treated with oral agents and not adequately controlled, followed by a 24-week extension period with insulin glargine for patients not adequately controlled with liraglutide

The primary objective of this study is to demonstrate the superiority of insulin glargine over liraglutide in termsof percentage of patients reaching a HbA1c < 7% at the end of the comparative period in Type 2 diabetic patientsfailing…

Genetic Susceptibility to Papilloma-induced Voice Disturbance

To discover human genes which are likely to confer susceptibility for recurrent respiratory papillomatosis

The role of corticosteroids on coagulation and inflammation in asthma

Primary objective:- To evaluate the effects of a 10 day-course of prednisolon on coagulation and fibrinolysis parameters in patients with mild-moderate astma, patients with severe asthma, and healthy controls.Secondary objectives:- To compare the…

Influence of ryanodyne receptor 1 mutations on pulmonary arterial pressure and ventilation during isocapnic hypoxia

W want to investigate the influence of a mutaion in the MH allel on the HPV and the normal reaction of MH patients to hypoxia

A novel neurophysiological measurement (MUNIX) in neuromuscular disorders; test-retest reliability and longitudinal follow up measurements in ALS patients

PrimaryTo investigate the inter-rater and intra-rater variability of a novel neurophysiological measurement (Motor Unit Number Index, MUNIX) for estimation of functioning motor units, in healthy controls and ALS patientsSecondaryTo evaluate the…

Study of the effectiveness of a coping self-help intervention for women in the waiting period after an embryo transfer during an IVF/ICSI treatment

To investigate if a short copingintervention reduces anxiety in patients undergoing an IVF or ICSI treatment in the UMCU during the waitingperiod after an embryotransfer.

Evaluation of an intervention to decrease the need for recovery in office employees by increasing daily physical activity and relaxation at work.

The aim of this study is to evaluate an intervention program consisting of group motivational interviewing (GMI), supported by a social media platform, and/or environmental modifications, to decrease the need for recovery in office employees by…

Long term prospective observational cohort study of the safety and efficacy of golimumab in the daily clinical practice of rheumatoid arthritis with emphasis on the lipid profile

To determinate the efficacy and safety of golimumab in rheumatoid arthritis patients in daily clinical practice during 48 months. In addition, the effect of treatment with golimumab on the lipid profile will be monitored during this study.

A Phase IIIb Double-Blind, Randomised, Placebo-Controlled Study of Patient Reported Outcomes in Friedreichâ¤*s Ataxia Patients after withdrawal from Treatment with Idebenone (PROTI Study)

The primary objective of the PROTI study is to establish whether patients can correctly determine which treatment assignment they received during the randomised phase of the trial.The key secondary objective is to compare the rate of withdrawal from…

Achilles tendinopathy, biomechanics with an adapted shoe

Primary Objective: The primary goal of this research project is to evaluate the effect of a rockered shoe on walking and running biomechanics in healthy athletes and athletes with Achilles tendinopathy. The reason for using a patient group is that…

The effects of ARA290 on the cognitive and neural processing of emotions in healthy volunteers

To study the effects of ARA290 on the cognitive and neural processing of emotions in healthy volunteers 7 days post-administration.

Can motor performance of chronic low back pain patients be improved via motivating feedback by means of gaming?

Determine whether feedback by means of motivational gaming can (partially) restore cognition-related deviations in motor performance as seen in back challenging conditions in CLBP patients.

Bone density as outcome parameter in haemophilia treatment

• Compare bone density between patients with mild haemophilic and those with severe haemophilia*.• Compare the relationship between treatment regimen: prophylactic (high-dose vs. intermediate dose) and on-demand and bone density.• Examine the…

Psychological interventions for familymember and partners of murdered persons

This study aims to determine to which degree the offered help - according to our treatment program - for familymembers and partners of murdered persons helps to treat complicated grief and PTSD (Murphy, 2006, Shear et al 2006) and to gain insight…

The effect of Local Infiltration Analgesia on postoperative pain in Total Knee Arthroplastia

Reduction of the postoperative pain in Total Knee Arthroplatia through the use of a peri- and intracticular injection of Local Infiltration Analgesia.

Ventricular Tachycardia Ablation vs. ENhanced Drug Therapy In Structural Heart Disease

To compare aggressive antiarrhythmic drug therapy to catheter ablation (ablation) for ventricular tachycardia (VT) in patients who have suffered prior myocardial infarction.

The effectiveness of a microscope during apical surgery; a prospective randomized controlled blinded clinical trial.

The objective of this study is to assess whether or not apical surgery that is carried out with the help of a microscope has a higher success rate than apical surgery without the use of a microscope. No RCT is found in present literature (Del Fabbro…

Long term follow up of the clinical and immunological responses following HPV 16 E6/E7 synthetic long peptides vaccination in women with HPV 16 positive vulvar intraepithelial neoplasia grade 3

To determine the long term clinical and immunological responses in patients with high grade VIN who have been vaccinated with an HPV 16 E6/E7 SLP vaccine approximately 3 years ago.

Sweet and Salt preferences in children that started weaning exclusively with fruit or with vegetables.

Objective: The main objective is to test the preference for sweet and saltwater solutions in infants that started weaning exclusively with fruit or with vegetables. Acceptance of sweet and salt intensity is compared between the fruit and vegetable…