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Baby breathing monitoring @home

The aim of the study is to collect video recordings which will be used retrospectively internally at Philips to test whether an algorithm can be used to measure the behavior and physiology of babies by using a camera and/or wearable. Development of…

A Prospective, Observational, Basket, Comprehensive Cohort Study of Children and Adolescents Aged Less Than 18 Years with Anemia Associated with Chronic Kidney Disease Requiring or Not Requiring Dialysis.

Primary:Evaluate the impact of SoC anemia management on Hgb concentrationsSecondary:- Characterize the use of ESA therapies in management of anemia associated with moderate to severe CKD in children and adolescents aged <18 years- Evaluate…

A multi-center, non-randomized study to characterize biomarkers in cerebrospinal fluid (CSF) of patients with infantile-onset (IOPD) or late-onset Pompe disease (LOPD)

To evaluate Hex4 concentrations in CSF from patients with infantile-onset (IOPD) and late-onset (LOPD) Pompe disease

Specturi Device - Feasibility study

Clinical feasibility of the urine collection device, indicated by staff and parents.

Pharmacokinetics of cytostatic agents and tyrosine kinase inhibitors in pediatric oncology

To assess the pharmacokinetics of various cytotoxic agents (carboplatin, cisplatin, cytarabine, dactinomycin, daunorubicin, dinutuximab bèta, doxorubicin, etoposide, methotrexate, vincristine or thiotepa) and kinase inhibitors (ALK, RAS pathway,…

Early Feasibility Data Collection using ClearSight on Children Less than Two Years Old.

In this study, we to confirm the cuff design and make sure it works. Aspects such as safety and ease of use are also evaluated.

Searching Patterns In the Robustness of Immunological FVIII Tolerance

The aim of SPIRIT is to investigate the mechanisms of the immunological tolerance to FVIII in patients with hemophilia A aged younger than 18 years using NFT for prophylaxis.

A Natural History Study of Exocrine Pancreatic
Function in Infants with Cystic Fibrosis Less Than
12 Months of Age

To characterize the natural history of exocrine pancreatic function as measured by FE-1 in infants with CF <12 months of age

Assessment of muscle properties in neuromuscular disorders: The muscle toolbox

Primary objective• To characterise natural disease progression rates of MRI- and/or US-assessed measures of muscle properties and muscle function and strength tests in children with neuromuscular disorders through standardized annual follow-up…

Ultrarapid genomics for the critically ill

We have recently implemented ultrarapid genetic testing using Nanopore long-read genome sequencing (LR-GS) at Erasmus MC to guide treatment and enhance outcomes in urgent care scenarios. In this study, we aim to retrospectively…

FOCUS

The primary objective of this research is to assess the occurrence, variability and underlying causes of treating pediatric patients with respiratory infections at the ED. This is done in order to identify and ultimately de-implement ineffective…