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The effects of internal and external attentional focus instructions on motor learning after stroke

The primary objective of this study is to assess whether motor learning using external attentional focus instructions results in superior single-task motor performance, movement automaticity, and dual-task performance in inpatient stroke patients…

e-COGRAT: The development, efficacy and implementation of *blended care* treatment in acquired brain injury-induced fatigue. First step: feasibility of e-COGRAT, a pilot study.

1) Is e-COGRAT usable within the ABI population?2) What are the patients* experiences with e-COGRAT?3) What are the therapists* experiences with e-COGRAT?4) What changes in the e-COGRAT are necessary?5) Does this pilot with e-COGRAT show a decline…

An open label, crossover study to investigate the safety and tolerability of Sifrol® (pramipexole) (Boehringer Ingelheim) prolonged release tablets in order to establish the maximum tolerable dose and to assess bioequivalence of Pramipexole prolonged release tablets (Synthon B.V.) compared to Sifrol® prolonged release tablets (Boehringer Ingelheim) in healthy subjects in steady-state conditions

To determine the relative bioavailability of pramipexole 4.5 mg tablets vs. 4.5 mg Sifrol in healthy subjects after up-titration.

The effect of transcranial direct current stimulation on processing speed in patients after ischemic stroke

To evaluate the effects of tDCS on information processing speed in comparison to sham tDCS in patients after stroke with ascertained reduced processing speed. A proof of principle study.

Brain metabolic changes during awake and asleep craniotomy measured by cortical microdialysis

Does anesthesia itself or transition of anesthesia to an awake state and vice versa lead to changes in the lactate/pyruvate ratio, glucose, glycerol and glutamate concentration as measured in the brain interstitial fluid?Are the metabolic…

Audiometric evaluation of tinnitus inhibition by cochlear implant stimulation.

To evaluate the efficacy of various masking strategies in cochlear implants as a treatment for tinnitus in patients with profound hearing loss.

Cognitive rehabilitation treatment of deficits in emotion, social cognition and regulation of behaviour after traumatic brain injury; development of treatment protocol and pilot study

To determine the feasibility and the estimation of the effect for the primary study parameter of a cognitive rehabilitation treatment for deficits in social cognition after traumatic brain injury.

Effect of functional power training on the walking ability of children with spastic cerebral palsy in the age of 4 to 10 years

The purpose of this study is to examine whether walking ability and plantar flexor strength of young children with CP who follow functional power training improve more compared to usual care.

Intra-subject reliability of non-invasive brain stimulation on lower limb motor control

The objective is to assess the intra-subject reliability of tDCS induced effects on the reaction time in the lower extremities of healthy subjects.

PITUITARY DAMAGE AFTER TRAUMATIC BRAIN INJURY;
Occurrence of growth hormone deficiency at long term follow-up and the beneficial effects of growth hormone substitution on cardiovascular performance, quality of life and functional abilities

To evaluate whether GH substitution in patients with an isolated GHD after TBI could reverse the severity of symptoms which characterize GHD.

Long-term effect modification by age of methylphenidate on the development of the dopaminergic system in the brain

Primary objective of the study: 1. To report on the long-term effect modification by age of MPH treatment on the outgrowth of the DA system using state-of-the-art Magnetic Resonance Imaging (MRI) techniquesSecondary objectives:1. To report on the…

The glutamate/GABA balance as novel therapeutic target for psychotic and cognitive symptoms in 22q11.2 deletion syndrome

The objective of this study is to examine the effect of riluzole on the glutamate/GABA balance in the brain in patients with 22q11.2DS. The secondary objective is to examine the effects of riluzole on psychotic symptoms and cognitive functioning. In…

Touch; reducing pain in Parkinson patients study 1

To determine whether CT optimal touch reduces pain experience in PD patients.

Evaluation of a Compensatory Brain Game supporting Goal Management Training intervention targeting executive function after Acquired Brain Injury using single-case experimental design methodology

The primary objective of this study is to assess whether the use of a compensatory brain game supported GMT treatment could be of interest in people with EF deficits after ABI, to improve goal achievement, their executive function performance during…

A Phase 1/2 Open-Label, Ascending Dose, Multicenter Study to
Evaluate the Safety and Preliminary Efficacy of AVB-101
Administered by Bilateral Intrathalamic Infusion in Subjects With
Frontotemporal Dementia With Progranulin Mutations (FTD-GRN)

Primary Objectiveo evaluate the safety and tolerability of a one-time, intrathalamic administration of AVB-101 in subjects with FTD-GRN.Secondary Objectiveo To evaluate the preliminary clinical and biomarker measures of efficacy of a one-time,…

REstoring CONsciousness with NEurostimulation of the Central Thalamus in patients with a persistent minimally conscious state (RECONNECT): a pilot study

To explore the efficacy of central thalamic DBS in restoring consciousness in MCS patients. Hypothesis: Central thalamic DBS improves the level of consciousness in MCS patients.