728 results
One of the he questions that remains to be answered to further elucidate the mechanism of action is whether ot not UAG improves insulin sensitivity during a euglycemis-hyperinsulinemic clampThis study aims to clarify the effects of the continuous…
The primary objectives of this study are: * To characterize the effects of 150 mg and 450 mg of AT1001 administered 2 hours before administration of agalsidase on the safety and plasma pharmacokinetics of agalsidase in subjects with Fabry Disease*…
The primary objective of this study is to investigate whether skeletal muscle glucose metabolism, perioperative glucose control and hemodynamics are affected by increasing physical activity in the weeks preceding surgery in patients identified with…
The objective of the study is to quantify endurance and respiratory function in subjects with MPS IV A and to better characterize the spectrum of symptoms and biochemical abnormalities in MPS IV A disease over time.
The major research objective is to examine if acute exercise results in a more pronounced increase in acetylcarnitine concentration in sedentary subjects compared to endurance-trained subjects and if the exercise-induced increase in acetylcarnitine…
To assess whether a change in BMD as detected big DXA (gold standard) is comparable with the decline measured by the achilles method
The objective is to sequentially test, validate, obtain regulatory approval for, and deploy at home, a closed-loop Control-to-Range (CTR) system comprising two algorithmic components: a Safety Supervision Module (SSM) and an automated Range…
This study primarily aims to explore changes in physical activity pattern and energy expenditure in head and neck cancer patients, during and after treatment with surgery with or without (chemo)radiation. The secondary aim of this study is to gain…
To investigate the dynamic changes in bone marrow adiposity during the menstrual cycle as assessed by Dixon*s Quantitative Chemical Shift Imaging (QCSI) measurements and to determine the role of estrogen in these changes.
The objectives of this follow-up/extension study of the VIPES study are:• To assess the efficacy of Viaskin® Peanut after up to 36 months of Epicutaneous Immunotherapy (EPIT) in peanut-allergic subjects.• To evaluate the safety of long-term…
To investigate whether increased aldosterone levels in obese individuals lead to impairment of microvascular function through reduction of NO-availability, and to establish the role of microvasculaire dysfunction in the pathogenesis of salt-…
Primary objective:To determine sAF levels in children and young adults with T1DM and in children with obesity with or without T2DM and determine the correlation between sAF levels and HbA1c in children and young adults with T1DM and in children with…
To investigate if the active product shows a postprandial plasma triglyceride profile different from the control product in healthy adult male volunteers.
To perform 31P-MRS during and after exercise using a specifically designed probe to determine variations in energy metabolism along the TA muscle in healthy humans subjects.
The main objective is to assess the efficacy of the closed loop system at the home of the patient. Secondary objectives are to assess the safety of the new prototype while the telemonitoring intensity is being reduced during the trial; to…
1a. Compare fat endocrine function in obese fit versus obese unfit people under resting conditions and immediately after exercise.1b. Compare fat endocrine function in non-obese fit versus non-obese unfit people under resting conditions and…
Research Questions: Primary:1. Does a single night of short sleep reduce metabolic flexibility following a mixed meal challenge?2. Does a single night of short sleep alter the responsiveness of the HPA-axis?3. Are the disturbances of a single night…
Primary objective of this study is to assess changes in brain connectivity and activity in the Default Mode and Salience Network (hypothalamus, prefrontal cortex, nucleus accumbens, Ventral Tegmental Area) after different sugars and sweeteners.
Primary objective of this trial is to generate open-label, long-term (up to 12 months) safety and tolerability data for ZS in subjects with hyperkalaemia (S-K * 5.1 mmol/L)Secondary objectives:* To evaluate the portion of ZS-treated subjects in whom…
There are two objectives for this study: first, to find specific serum beta cell damage markers that can serve as a clinical predictive tool for beta cell allograft loss. Second, to compare quality of life and diabetes-related outcomes in patients…