27 results
• Compare bone density between patients with mild haemophilic and those with severe haemophilia*.• Compare the relationship between treatment regimen: prophylactic (high-dose vs. intermediate dose) and on-demand and bone density.• Examine the…
To investigate in vivo whether a measurable increase in systemic ATP levels occurs in response to mechanical stimulation of bone in humans.
It is our goal to predict the efficacy of glucocorticoid-treatment of RA patients by means of a list of markers predicting the reponse to GC treatment in order to avoid ineffective but potentially harmful treatment in the glucocorticoid non-…
Primary Objective To assess the feasibility and safety of combining stereotactic body radiotherapy and pedicle screw fixation in a 48-hour window for the treatment of painful unstable metastases of the thoracic and/or lumbar spine.Secondary…
Primary Objective: To evaluate the change in serum βCTX in patients who start with HCQ treatment.Secondary Objective(s): To evaluate the change in serum PINP and BAP in patients who start with HCQ treatment
To determine the incidence of radiological adjacent segment pathology (RASP) at 5 and 10 years after posterior and anterior fusion performed for low grade L5-S1 isthmic spondylolisthesis, and to evaluate the clinical outcome.
The objective of this study is to evaluate whether an in- or outpatient initiation of the brace treatment has an influences short and long term brace compliance.
The aim of the present study is to use a more complete analysis of spinal motion (using a 3D multi-segment spine model) and to introduce challenging gait tasks which can optimally reveal the compensation strategies of the spine. Furthermore, static…
The goal of this trial is to find the best available conservative treatment, based on subjective pain scores, for children with Sever*s disease. Our primary objective is to score the possible decrease of pain experienced by the subjects. This will…
The primary objective of the study is to evaluate the effect of denosumab 60mg every 6 months (Q6M) compared with Actonel 150mg monthly (QM) on total hip Bone Mineral Density (BMD) at 12 months in postmenopausal women transitioning from previous…
To investigate the long term stability (> 5 yrs) in patients treated with mandibular distraction osteogenesis (MDO) for correction of a Class II-occlusion. Hypotheses:1) MDO is a technique for mandibular lengthening with comparable stability…
The purpose of the study is to investigate whether the cyclodextrin added to the cholecalciferol formulation has an effect on the vitamin D3 availability in the body. Thus, it will be investigated if concentrations of vitamin D3 that are found in…
The objective of the study is to obtain information on the bioavailability and pharmacokinetics of the phenolics present in an olive leaf extract (Bonolive®, dose 250 mg), standardized on 40% oleuropein, and to identify the composition of the…
In patients with benign bone tumors, the defect originated from curretage of the tumor, will be filled with Progentix TCP. The bone regenerative capacity of Progentix TCP will be compared to the capacity of autologous bone (the golden standard).…
We propose a protocol to invite patients with unicondylar fractures identified from the AMC database to return for evaluation and radiographs in order to collect long term (>10 years) data regarding the outcomes of these rare fractures.
To describe the safety and tolerability of up to 5 years denosumab administration as measured by adverse event monitoring, immunogenicity, and safety laboratory parameters in subjects who previously received denosumab.
The aim of this project is to do an objective and subjective functional long-term outcome assessment of patients with distal radius malunions, treated with intraarticular osteotomy and therefore evaluate factors that are good outcome predictors for…
The primary objective is to determine whether micro-structured TCP granules provides sufficient bone volume as basis to insert endosseous dental implants in a two staged sinus floor elevation technique by benefiting from the clinical handling…
We will investigate whether wearing the insoles can cause a reduction in the hallux valgus angle and the angle intermetatarsaal angle. Furthermore, we investigate the possible decrease in pain and improvement in functional score.
The PRE-FURTHER project aims to evaluate the feasibility of the combined EBRT and MR-HIFU treatment for relief of metastatic bone pain, and to optimize the combined treatment logistics.