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An Open-Label Drug-Drug Interaction Study in Healthy Male Subjects to Explore the Effects of Single and Multiple Doses of JNJ-39393406 on the Pharmacokinetics of a Single Oral Dose of Midazolam

The purpose of this investigation is: • To examine the effect of single and multiple doses of the new drug JNJ-39393406 (the study medication) on absorption, metabolism and excretion by the body after single administration of the drug midazolam.• To…

Non-Adherence with Psychoeducation in patients with Schizophrenia Study (NAPSS):
prevalence, risk factors and outcomes

1. To compare patient outcomes during follow-up between adherents versus non-adherents with psychoeducation in patients with schizophrenia. We selected *time to (re)hospitalisation* as the most important outcome.2. To assess the prevalence and risk…

Beat Victimization! Feasibility study for a psychomotor assertiveness training with elements of kickboxing for people with a psychotic disorder

In preparation for a multicentre randomized controlled trial (RCT) we want to test the psychomotor assertiveness training in a feasibility study. The aim of this study is threefold: 1) We want to evaluate and improve intervention protocol also using…

Prediction of psychosis: a follow-up study.

HypothesisChildren and adolescents with non-psychotic psychiatric disorders represent a vulnerable group high prone for psychotic symptoms. In contrast with normal populations more pronounced symptom and cognitive profiles will be found predicting…

Phenomics and Genomics of Clozapine Pharmacotherapy - New Clozapine Users

To investigate whether methylation patterns/levels and gene expression profiles predict treatment outcome after initiating CLZ.

Voices, Attachment and Trauma (VAT): a study on the recovery of people with severe mental illness

The VAT study aims to investigate which factors influence and predict the different areas of recovery. VAT also examines how the content of voices that patients hear should be mapped and registered. We examine whether these factors can predict…

Prediction of REsPonse to Antipsychotics using electRoEncephalography

The aim of this study is to validate EEG prediction markers of antipsychotic treatment outcome in patients with psychosis. *

Antipsychotics: about Safety, Acceptation and Pharmacokinetics in adults

In the ASAP study, we aim to investigate pain associated with capillary sampling in a population of patients with serious psychiatric problems, compared to pain associated with standard venous access. This study is a pilot for a planned larger study…

Pilot study on Ketosis Impact on Signs and Symptoms of Schizophrenia and Bipolar Disorders

The current pilot study intends to establish the effect of a single dose of dGK on relevant (neuro-)electrophysiological (primary outcome: Pre-Pulse Inhibition (PPI); furthermore on resting EEG, on the ERP P300, cognitive, metabolic, inflammatory,…

Language In PSychosis

The main objective of the LIPS study is to use NLP and SLP quantitative features as well as passive sensing data to predict psychotic relapse above chance both at the group and individual levels. The LIPS study will also retrospectively assess, as…