61 results
To determine the effects of biphosphonates on radiation induced microvascular damage in the skin of breast cancer patients by comparing skin biopsies taken prior to and 4 months after treatment with a biphosphonate.
This study will investigate the effect of shear and pressure on tissue viability of human skin. Skin vitality is determined by tissue oxygenation and blood flow, measured with the 'Oxygen to See'. The focus will be on individual response…
To investigate biomarkers that play a role in the induction and resolution of AD.Secondary objective: to develop therapeutic interventions (pharmacologically) based on the revealed biomarkers.
The primary objective of this study is to evaluate whether the recovery of the skin barrier after acute perturbation by repetitive application of adhesive tape (*tape stripping*) is accelerated following irradiation with visible light. The secondary…
1. To characterize long-term neurologic- and cognitive disorders, audiological and ophthalmological alterations in cCMV-infected children.2. To identify immunological, neurological host factors and virological factors that are predictive of…
This is a pilot study with the objective of studying the effect of vaselin on TSLP expression in nonlesional human AD skin.
In the present study we sought to determine the levels of IL-1 cytokines in the SC and to relate them to FLG genotype, pH and the levels of filaggrin degradation products. Furthermore, we aim to investigate whether FLG genotype status relates to the…
The objective of the study is mapping and assessing of the effects of filaggrin mutation on atopic eczema and other atopic diseases together with serological parameters.
With this project we would like to answer the following questions:To what extent do we observe Treg toTh17 conversion in inflammation of the human skin, as elicited in response to general standardized skin injury (i.e. tape-stripping and topical…
1) to examine the expression of cytokeratins and Notch in healthy human FPSUs at different segments. 2) to describe the association between expression of the cytokeratins and Notch 1 in the FPSUs of healthy volunteers.
1. To investigate the relative contributions of different ocular abnormalities to the visual function.2. To investigate the precise relationship between ocular pigmentation and the development of the visual system abnormalities.
Primary Objective: What is the frequency of positive patch test reactions to the 26 declarable fragrance allergens in fragrance mix I and/or II positive participants?Secondary Objectives: Do Weleda cosmetic products containing essential oils,…
To examine whether the use of systemically administered antibiotics in therapy resistant Lichen Sclerosus leads to:- Relief of symptoms- Improvement of clinical picture- Improvement of histological abnormalities- Effect on quality of life-…
The objective of tje study is to investigate the lipid organization and composition in the SC of AE patients and healthy subjects in relation to the water and nmf-content in the SC.
To estimate the one year-prevalence of contact allergy to fragrance ingredients in the general population of six different geographical areas in Europe spread over five different countries
Aim of the studyIn addition to the aims of the compassionate use protocol.To study:1. hypothalamic structure before and during leptin therapy2. hypothalamic function before and during leptin therapy
The present proposal aims at detecting the pathogenesis of keloids in RTS by studying 50 RTS individuals from 3 countries (Netherlands, Norway, UK) with keloids clinically, and take 3 biopsies in 5 of them from normal skin, edge of normal skin-…
The objective of this studie is to gather knowledge about cytokine concentrations (IL-1 *) in the skin of healthy volunteers after the application of shear- force. We want to use this knowledge in the future to investigate if different prophylactic…
This study's major aim is to determine whether a relation can be found between specific penile HPV types and the presence, quantity and size of flat penile lesions. Secondly, other possible determinants, such as HIV status, circumcision status…
Primary objective is to determine the actual occurrence of and risk factors for OCD on the hands of Dutch construction workers.With these new insights into the risk factors for OCD, we aim to develop 1) a new diagnostic tool to be used by…