18 results
Primary Objective: 1. To compare total testosterone levels between male CCH and ECH patients and healthy controls To compare total testosterone levels in males with ECH during remission (remission ECH) and during an active…
To investigate whether high perceived stress is associated with inflammatory reprogramming of innate immune cells and their bone marrow progenitors, and with increased arterial wall inflammation, in subjects with an increased CVD risk.
In this study, we therefore aim to investigate how trained immunity is systemically regulated in kidney transplant patients and how the degree of trained immunity affects graft survival in patients. A better understanding of these processes…
Previous studies have shown that the origin of trained innate immunity lies in the bone marrow and is determined by epigenetic and metabolic reprogramming in hematopoietic stem and progenitor cells. In this study, we investigate whether long-term…
To demonstrate the ability of using non-invasive 31P-MRS to monitor changes of in vivo markers of mitochondrial function in skeletal and cardiac muscles (i.e., skeletal muscle PCr recovery rate constant and cardiac PCr/ATP ratio)…
The aim of the THRIVE study is to examine two objectives: 1. What are the mechanisms through which friendships aid resilience?a. Does friendship support relate to reduced neural stress responses in young adults with CA?b. Does friendship…
To gain insight in the disease mechanisms of IBD, the immune system, gut and oral microbiome, environmental factors, the intestinal mucus barrier, intestinal epithelium, nutritional factors and metabolome will be studied in unaffected siblings of…
Primary objectives: 1.1) To investigate to what extent the different functions of the cerebral microvasculature are impaired in type 1 diabetes; and 1.2) To investigate to what extent the different functions of the cerebral microvasculature are…
Primary objective: to register and investigate Dutch patients suspect for an inherited platelet function disorder, to assess clinical presentation, bleeding score, treatment, burden of disease and quality of life. Secondary objectives: to…
The main descriptive and analytic objectives are: Descriptive: To gather epidemiological evidence (prevalence, incidence) about the course of the mental, musculoskeletal and neurocognitive health (dependent variables) of…
Which markers and which vascular calcifications can be used as diagnostic markers in the dectecion of heart failure with preserved ejection fraction and diastolic dysfunction. Diabetes is a progressive disease. We therefore expect…
To identify the effect of psoriasis and the treatment with biologics on the pre-pregnancy uterine immune environment of psoriasis patients.
To assess the impact of short-term forearm immobilization on forearm muscle glucose uptake and amino acid net balance and kinetics of individuals with T2D compared with a control group with normoglycaemia.
This study aims to develop a RI using CTA-based CFD simulations for estimating the hemodynamic significance across mesenteric arterial stenoses (MAS).
The aim of this study is to objectively determine physical activity levels and to explore factors associated with the level of physical activity during hospital admission in hospitalized children between six months and 18 years old.
The purpose of this protocol amendment is to meet the current and future needs of the MacTel Project’s collaborating investigators and continue meeting initial objectives. In addition, a third objective is to understand the mechanisms involved in…
The main aim of this study is to investigate how brain water oscillations measured with NIRS correlate to blood pressure.
Better knowledge of the clinical phenotype/natural history and genotype of Traboulsi Syndrome.