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Target Molecules and their Respective Pathogenic and Protective Antibodies in Myasthenia Gravis.

The aim of this study is to develop an immortalised B-cell line derived from MG patients. This antibody producing cell line will be used for different applications:- The establishment of new passive transfer disease models for MG- The identification…

Purinergic signalling in human osteoporosis:
Evaluation of variability in purinergic receptor genes and receptor function

Within WP6 of a EU Seventh Framework project, we will investigate associations between purinergic receptor SNPs and osteoporosis risk in humans. Genetic data from a fracture cohort in The Netherlands with high prevalence of osteoporosis will be…

Pathogenesis of community-acquired pneumonia, chronic obstructive pulmonary disease and cystic fibrosis: mechanism of inflammatory response and the role of Th17 differentiation

To assess whether Th17 cells play a central role in COPD, CF and pneumonia pathogenesis

Impulsivity, a risk factor in relapse to substance use disorder: investigating neural substrates before and after pharmacological challenges.

The goals of the proposed study are: (1) to further elucidate the relations between impulse control, motivational strength of drug cues, and brain activation patterns (using fMRI); (2) to examine the relative strength by which these processes are…

Regulation of muscle oxidative phenotype by hypoxia in Chronic Obstructive Pulmonary Disease and Chronic Heart Failure

The aim of this study is to identify direct markers of muscle and adipose tissue hypoxia in COPD and CHF patients in relation to the altered muscle oxidative phenotype and the putative mediators HIF-1α and PPARs/PGC-1. Insight in the underlying…

Characterisation of regulatory T cells and cytokine production in children diagnosed with asthma

To characterise the number, phenotype and functionality of regulatory T cells and cytokines produced in the peripheral blood of children diagnosed with asthma.

Imaging in amyotrophic lateral sclerosis;
novel biomarker research with 7Tesla MRI

Identify and further explore the structural brain alterations in ALS patients in comparison to healthy controls and to investigate the correlations of anatomical changes with clinical variables.

The role of indoleamine 2,3-dioxygenase in virus-induced asthma exacerbations

With this project we aim to clarify the differences in airway pathophysiology between asthmatics and healthy controls that underlie the prolonged survival of virus and the exaggerated inflammation in virus-induced exacerbations of asthma. We will…

Functional brain imaging of the influence of interoceptive awareness and autonomic nervous system function in pain processing in fibromyalgia

This study will investigate the relationship between autonomic nervous system function and pain in fibromyalgia, with a specific emphasis on awareness of bodily sensations, also refered to as interoceptive awareness, as a potential modulator of pain…

Unravelling the etiology of chronic idiopathic axonal polyneuropathy

Objectives1. Achieve a complete ascertainment of incident CIAP patients in the middle of the Netherlands during a three-year period and determine the frequency of CIAP.2. Establish whether CIAP is associated with the metabolic syndrome, and if so,…

Seizures in stroke patients.

Firstly, measurement of the impact of seizures in stroke patients by comparing quality of life, cognitive function, disability, handicap, and mood between stroke patients with and without seizures.Secondly, recording information on treatment of post…

Haemodynamics, arterial stiffness and endothelial function in young prehypertensive subjects

1. to investigate early haemodynamic alterations and endothelial function in young prehypertensive medical students; 2. to examine the possbility to improve these haemodynamic changes after exposure to an endothelial dependent (salbutamol) and…

The clinical importance of the neonatal Fc receptor in RPE.

1) To demonstrate that the FcRn functions as a transporter and protector for vitreous IgG and monoclonals (Avastin, Lucentis) and show that monoclonal therapeutic antibodies are transported over the RPE via the FcRn. 2) To investigate if…

The role of pain catastrophizing in the mood-as-input model

The aim of the experiment is to test whether people who catastrophize about pain stop sooner with a task in a negetaive mood than in a positive mood

Functional studies in different forms of hyperkinetic movement disorders

The purpose of this study is to obtain a better understanding of the pathophysiological substrate of jerky movements, with a focus on psychogenic jerks, myoclonic jerks in Myoclonus Dystonia, and tics in Gilles de la Tourette syndrome.

In vitro activation of monocytes from pregnant women by different types of bacterial lipopolysaccharides leads different immunological pathways

Objective of this study is to investigate cytokine production and expression of toll-like receptors on monocytes in blood samples from pregnant and non-pregnant women using sonicates from different types of oral pathogenic micro-organisms and…

Assessment of endothelial function, accumulation of advanced glycation end products and atherosclerosis in patients with longstanding Rheumatoid Arthritis

1. Is EC dysfunction, measured by PWA, present RA patients?2. Is EC dysfunction in RA related to EC activation markers (CRP, thrombomodulin, sVCAM, vWF), AGEs, and the presence of atherosclerosis?3. Is EC dysfunction related to traditional…

Functional MRI during Sleep in Patients with Posttraumatic Stress Disorder

The current study assesses activation of hippocampus and prefrontal cortex during sleep spindles in veterans with and without PTSD. Furthermore, the correlation between sleep spindles and memory consolidation will be examined.

International study on etiology of inhibitors in patients with a moderate or mild form of hemophilia A, influences of immunogenetic and hemophilia treatment factors.

The aims of this project are:A. To describe the incidence of inhibitor formation in moderate/mild hemophilia A patients.B. To identify clinical and genetic factors that induce inhibitor formation in patients with moderate/mild hemophilia A.C. To…

The role of genetic variations in type I Interferons related to respiratory tract infections in Down Syndrome children.

The main objective is to identify a difference in mRNA expression level of IFN and IFN related genes between Down Syndrome children and a control group of healthy children (siblings). The secondary objective is to identify a relationship between…