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Implementation of a home-based computerized cognitive rehabilitation program for patients with acquired brain injury

Patients with ABI follow a multidisciplinary rehabilitation program. This program is very intensive and also requires a lot from loved ones. The burden can be reduced by partly delivering the program from home.The aim of this project is to implement…

The DRAGON-PLC trial: An international multicentre randomised controlled trial to compare combined Portal and Hepatic Vein Embolisation (PVE/HVE) with PVE alone in patients with primary liver cancers.

To evaluate the effect of combined PVE/HVE compared to PVE alone on resectability and overall survival in patients with primary liver cancers.

HIPPI shoulder - Hip-allograft In Proximal humerus fractures versus Plate Implantation alone: a randomized controlled trial

The aim of this RCT is to examine the differences in functional, clinical, and radiological out-comes, between LCP fixation alone and femoral allograft augmentation in addition to LCP. Ultimately, the purpose is to optimize treatment strategies and…

Restorative Deepfake Intervention Netherlands (REDEFINE):
Deepfake survivor-perpetrator confrontation for young adults with sexual violence-related PTSD

To evaluate the acceptability and effectiveness of a deepfake victim-perpetrator confrontation in young adults with sexual violence-related PTSD.

Laparoscopic versus robot-assisted left-sided pancreatectomy for benign and pre-malignant lesions (DIPLOMA-3): an international multicenter patient-blinded randomized controlled trial

To compare L-MILP with R-MILP for benign and pre-malignant lesions of the pancreas in high-volume centers, regarding:1. Peri- and postoperative outcomes in terms of COMPOS-panc left score, for non-inferiority2. Total hospital-related costs, for…

Deliver mOre aPplications for more durable Pulmonary vein IsOlation with the Pentaspline Pulsed Field Ablation catheter, the DOPPIO trial

to determine if freedom of AF may be improved by delivering more, and targeted PFA applications while avoiding side-effects of higher PFA dosing.

A comparison of pericapsular nerve group block, fascia-iliaca compartment block and femoral nerve block for pain management in patients with hip fracture in the emergency department - A randomized controlled trial

The aim of this study is to compare the efficacy and safety of preoperatively placed Pericapsular Nerve Group block (PENG), Fascia-Iliaca Compartment Block (FICB) and Femoral Nerve Block (FNB) for patients with hip fractures in the ED.

Splintless versus conventional maxillomandibular advancement surgery for obstructive sleep apnea: a randomized controlled trial

The main objective is to investigate if splintless approach improve the surgical accuracy of MMA for OSA. The secondary objectives are to assess the effect of splintless MMA on duration of surgery, blood loss, adverse events, respiration function,…

Online Breathwork-Assisted Therapy for Social Anxiety

Primary Objective: The primary objective is to assess the effectiveness of HVB-assisted therapy (HV-BAT) in reducing self-reported SA.Secondary Objectives: The secondary objective is to assess the effectiveness of HVB-assisted therapy (HV-BAT) in…

Tissue-level versus bone-level single implants in the posterior area, a randomized clinical trial

This study aims to evaluate and compare the long-term outcomes of tissue-level and bone-level single implants in the posterior region of the mandible or maxilla in patients with adequate bone for implant placement, with or without prior bone…

Are muscle characteristics associated with the effect of exercise training on muscle strength in rheumatic diseases and sarcopenia? - an explorative study
The Care for Muscle (C4M) Study

Primary Objective: To study the association between muscle characteristics (contractile, morphological,biochemical, and histological) and the response to high- and low-load exercise training on muscle strength in patients with rheumatoid arthritis (…

A PrOspective RandoMIsed Study of Treatment Selection Based on Epigenetic Markers Versus Standard of Care Treatment Selection in Adults With

Primary: To compare the efficacy of epigenome-guided treatment selection to usual standard of care (SOC) treatment selection for inducing clinical remission and endoscopic response at Week 26 in participants with active CD.Secondary:-To explore the…

CATALYST: Cataract Surgery in Conjunction with Ab-interno Canaloplasty Compared to Cataract Surgery Only in Patients with Mild to Moderate Primary Open-Angle Glaucoma

To demonstrate the clinical efficacy and safety profile of canaloplasty utilizing the iTrackTM Advance canaloplasty device performed via an ab-interno surgical technique achieves:1. Enhanced IOP reduction at 12 months due to the techniques ability…

Balloon pulmonary angioplasty versus pulmonary endarterectomy in patients with chronic thromboembolic pulmonary hypertension: a non-inferiority randomized trial

To evaluate if balloon pulmonary angioplasty (BPA) is non-inferior to pulmonary endarterectomy (PEA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) who are eligible for both treatments.

The role of glucocorticoid receptor sensitivity in congenital adrenal hyperplasia

The aim of this study is to investigate the GRS in CAH patients and compare these findings with patients with Cushing's syndrome and healthy controls. Additionally, this study will examine the influence of PS and AA on GRA to better understand…

ShOrt neCK AAA RAndomized Trial - ESAR and FEVAR: SOCRATES
Physician-Initiated Trial Investigating ESAR (EVAR Plus Heli-FX EndoAnchors) and FEVAR for the Treatment of Aortic Aneurysms With Short Infrarenal Aortic Neck

The aim of this randomized study is to compare the safety and performance of EndoVascular Aneurysm Repair with ESAR using Endurant + Heli-FX EndoAnchor and FEVAR using customizable grafts from Cook (Zenith Fenestrated Graft) and Terumo (Fenestrated…