33 results
Main study:We want to assess whether bleeding risk in women with uterine leiomyomas is associated with CK activity and attenuated platelet aggregation.Objective of pilot study:Firstly, to perform a feasibility pilot of CK/AK measurement in menstrual…
The aim of the project is to examine the association between clinical, environmental and genetic characteristics of the recipient of erythrocyte transfusions and the risk or resistance to immunization against erythrocyte alloantigens that he/she was…
The objective of this study is to investigate if the Thrombin Generation Curve has an additional, possible more accurate, value besides the conventional tests such as PT, APTT, INR, AT and the mearument of coagulationfactors for determining…
To get more insight into the T cell homeostasis in lymfocytopenic, ATG treated patients and normocytopenic patients treated with standard maintenance immunosuppressive drug therapy.
1. To compare the platelet function between healthy controls and patients with ET under both static and dynamic conditions. 2. To study the effects of anagrelide and hydroxyurea on platelet function. 3. To study the intrinsic platelet activation…
In our laboratory we are able to characterize and culture MSCs. In order to study more extensively the possible alterations in MSC biology in AA we will investigate bone marrow cells of patients with newly diagnosed AA and at the time of response…
Main: Investigate the cyclic variation in clot lysis time in women with HMB in comparison to controls. Secondary:- Investigate the cyclic variation in TAFI, PAI-1, tPA, PI, thrombin generation, fibrinogen, fibrin clot permeability and confocal…
We plan to compare the costs and effects of both methods.
MRI vessel wall characteristics of peripheral arteries and arterial stiffness in hemophilia patients
The primary objective is to analyze and compare morphological (media- thickness) and functional (stiffness) vessel wall parameters of peripheral arteries between hemophilia patients with an ankle- brachial index >= 1.3 and hemophilia patients…
To sess the relationship between cerebral perfusion and clinical findings (neurological and neuropsychological) in patients with sickle cell disease.To compare iamging fincdings in children with and without sickle cell disease.
The objective of the study is to gain new insights in the causes of a higher clopidogrel resistence in type II diabetes mellitus patients
To investigate the relation of platelet responsiveness and systemic platelet activity to phenotype in patients with severe hemophilia A.
Main: To confirm the findings of our previous, explorative study that the overall FXI plasma levels in patients with menorrhagia are lower than in controls. Secondary: To establish the prevalence of FXI mutations/polymorfisms in patients with…
To get more insight into lymphocyte kinetics during immune reconstitution after hematopoietic stem cell transplantation
To characterise the different platelet activating pathways using the FACS assay and the different steps of primary hemostasis with a perfusion flow model in patients with hereditary thrombocytopathies; Storage Pool Disease (SPD), Glanzmann*s…
The overall aim of this study is to evaluate the use of the thrombin generation test in patients with CKD, including haemodialysis-dependent patients.
This observational cohort study is designed to evaluate the prevalence of acquired von Willebrand*s syndrome in patients with a new diagnosis of overt hypothyroidism.
The main, primary objective of this study is identification of the molecular mechanisms that regulate structure and function of red blood cells in patients with neurodegeneration accompanied by the presence of abnormal red blood cells (…
- The primary research objective is to estimate the prognosis of children affected by ICL. - A secondary research objective is to explore the heredity of ICL between first degree family members.
To elucidate the pathogenetic mechanism of endothelial cell activation in DENV infected patients with sickle cell disorder.