44 results
The primary objective in the glucocorticoid-continuing subpopulation of men and women treated with chronic glucocorticoid therapy (>= 7.5 mg daily prednisone or its equivalent for >= 3 months and are planning to continue treatment for…
1. The primary objective is to evaluate the characteristics of the distal radial growth plate on MRI (including functional imaging techniques) and on conventional radiographs in young gymnasts with wrist pain, compared to young gymnasts without…
The primary goals of this study are to: i. Identify genetic variations responsible for PLP across the whole genomeMore than 90% of SNPs are found in introns or intergenic regions and most of them are probably of little functional consequence.…
The purpose of the study is to investigate the effect of (repeated) cast immobilization on the bone strength of the lower leg in patients with diabetes mellitus. In this study, bone strength is examined by cortex thickness in millimeters and density…
What is the most optimal treatment strategy for children / adolescents with knee complaints? Our hypothesis is (based on the invasive surgical procedure) patients that will be surgical treated (index group) have a clinical relevant gain of pain…
To assess the effect of AMG785 treatment for 12 months followed by alendronate treatment compared with alendronate on the incidence of clinical fracture and new vertebral fracture.
Our aim is to study whether the pain response after three months in patients with bone metastatic disease increases after SBRT in comparison to low dose EBRT.
Effect on bone mineral density.
The aims of the present study are 1) to confirm the high prevalence of dRTA in Sjögren using the urinary acidification test with ammonium chloride, 2) to determine the prevalence of disorders in calcium metabolism in pSS patients with dRTA, 3) to…
To investigate whether bone mineral density is lower in apheresis donors than in blood donors.
To study the inflammatory response (induration) to intracutaneous Candida albicans in healthy individuals, patients with diabetes without polyneuropathy, patients with diabetic polyneuropathy and patients with a history of Charcot neuro-…
The objective is to study the effect of beta-agonist and beta-antagonist treatment on human bone remodeling.
What is the effectiveness of an epidural painmanagement compared with a PCA method as postoperative treatment after an epiphysiodesis for adolescents during the first 5 days after the procedure?
This will be a pilot study that aims to gain insight into the effect of Gaucher disease on bone metabolism. For this purpose we formulated the following research questions:What is the effect of inflammatory factors in the serum of patients with…
To test the surgical feasibility of the less invasive percutaneous pedicle screw instrumentation system for the treatment of children with a so called "hypotonic" scoliosis. Additionally, postoperative pain reduction and a reduced hospital…
The Purpose of this study is to compare the surgical treatment of flail chest with the non-operative treatment regarding complications.Hypothesis: Surgical stabilization of rib fractures in flail chest results in fewer respiratory complications,…
In this exploratory pilot study, we aim to investigate the role of immune activation in osteoporosis in HIV-infected patients on HAART with proven osteoporosis/ osteopenia in comparison to HIV-infected patients on HAART without osteoporosis/…
The Sciatica-Gill trial is a randomised cost-effective study about nerve root decompression according to Gill versus instrumented fusion in the treatment of patients with radicular legpain or neurogenic claudication due to spondylolytic…
To investigate whether parents of children with adolescent idiopathic scoliosis have a significantly different neutral upright sagittal alignment compared to adult volunteers whose offspring does not have adolescent idiopathic scoliosis.
To determine if denosumab is non-inferior to zoledronic acid (Zometa) with respect to the first on-study occurrence of a skeletal-related event (SRE) in men with hormone-refractory prostate cancer and bone metastases.