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CD4+ T cells and immune ageing; major players and predictors for disease activity in giant cell arteritis

Primary Objective: to study the differences in CD4+ T cell subsets (Th1/Th2/Th17/Tregulatory/Tsenescent) between GCA patients and healthy controls at diagnosis and during follow up and in remission. Secondary Objective(s): - To characterize the cell…

Scleroderma target discovery

Because the pathophysiology of SSc is unknown, there is currently no treatment available to cure the disease itself, so only individual organ system complications are treated (7,8). Therefore, treatment is patient-specific and aimed at ameliorating…

Control of breathing in systemic sclerosis

-To assess the central chemosensitivity by an carbon dioxide rebreathing test-To assess mouth occlusion pressures during the carbon dioxide rebreathing test-To study the relation between these results and the results obtained with the MRI and…

Genetic origin of Dupuytren*s disease and associated fibromatosis

The purpose of this study is to further unravel the genetic origin of these individual diseases and their relation at genes level.

COLPOP
'"Collagen metabolism in patients with and without Pelvic Organ Prolapse; a pilot study*

To investigate the collagen metabolism in pelvic floor tissue, pelvic floor-derived fibroblasts, and adipose tissue stem cells in patients with and without pelvic organ prolapse (POP)

Assessing the frequency, phenotype and function of plasmacytoid dendritic cells and T cells in blood and skin of patients with skin fibrosing disorders

To investigate the difference in number, phenotype and function of plasmacytoid dendritic cells and T cells in and between patients with SSc, LS and EF and between patients with these diseases and healthy controls / patients with psoriasis.