107 results
To fully characterize skeletal muscle strength and endurance, phenotype and muscle fiber type-specific satellite cell content in frail elderly as compared to those elderly that do not classify as frail according to clinical criteria.
The purpose of the study is to investigate the effect of (repeated) cast immobilization on the bone strength of the lower leg in patients with diabetes mellitus. In this study, bone strength is examined by cortex thickness in millimeters and density…
Objective: We want to extend our understanding of the disease aetiology by performing a small pilot study that incorporates other immunologic sites involved in the disease (the skin and the microbiome) while additionally strengthening our disease…
PRIMARY OBJECTIVE1. To determine the contractile strength and the (ultra)structure of single diaphragm muscle fibers of mechanically ventilated patientsSECONDARY OBJECTIVE1. To determine whether diaphragm muscle fiber weakness is part of a…
Primary Objective: to study the differences in CD4+ T cell subsets (Th1/Th2/Th17/Tregulatory/Tsenescent) between GCA patients and healthy controls at diagnosis and during follow up and in remission. Secondary Objective(s): - To characterize the cell…
Previous studies [10] have proposed that cartilage degeneration due to obesity could be caused by changes in the joint kinematics during ADL that shifts the loading applied to cartilage. Such a shift may cause regions of cartilage to become newly (…
The aim of this project is to determine the possible use of biomarkers for non or delayed union in long bone fractures of the diaphyseal femur and tibia.
The aim of this study is to develop an immortalised B-cell line derived from MG patients. This antibody producing cell line will be used for different applications:- The establishment of new passive transfer disease models for MG- The identification…
Measuring the brain activity in patients with chronic WAD and compare the results with those obtained in healthy volunteers. The goal of this research is to better understand the cause of chronic WAD and how to better treat the WAD-patients.
The aim of this project is to determine the possible use of biomarkers for non- or delayed-union in fractures of the diaphyseal femur and tibia.
Within WP6 of a EU Seventh Framework project, we will investigate associations between purinergic receptor SNPs and osteoporosis risk in humans. Genetic data from a fracture cohort in The Netherlands with high prevalence of osteoporosis will be…
The primary objective in this study is to detect the presence of supra-spinal central sensitization in patients with chronic neck pain secondary to cervical facetal arthropathy. We aim to show this by comparing the pressure-pain thresholds (PPT; the…
The goal of this study is to establish differences and agreements in the integration of vestibular, visual and somatosensory information and in the neural regulation of head position between girls with idiopathic scoliosis, woth congenital scoliosis…
To clarify the aetiology of CTS and prognostic factors for the development of CTS.
The aims of the present study are 1) to confirm the high prevalence of dRTA in Sjögren using the urinary acidification test with ammonium chloride, 2) to determine the prevalence of disorders in calcium metabolism in pSS patients with dRTA, 3) to…
Primary objective(s): Is to determine the effect of botulinum toxin injections on postoperative pain and discomfort after an arthroscopic rotator cuff repair.Secondary: To determine whether postoperative immobilization of the rotator cuff, after…
Primary Objective: To investigate which underlying muscle properties can explain (expected) differences in strength between subjects with and without OA, and how muscle strength, voluntary activation and fatigability are related to function.…
The primary objective of this study is to examine whether distraction interferes with CPM modulation differently in patients with fibromyalgia compared to healthy controls. Secondary objectives include assessing whether patients have a general…
To study the inflammatory response (induration) to intracutaneous Candida albicans in healthy individuals, patients with diabetes without polyneuropathy, patients with diabetic polyneuropathy and patients with a history of Charcot neuro-…
The first aim is to determine see if knee proprioception is related to patellar tendinopathy. The second aim is to study whether application of a patellar strap influences proprioception.