20 results
A prospective randomized phase III clinical trial to study the effectiveness of pathogen-reduced platelet concentrates in plasma, stored for up to 7 days, and compare these with untrested platelet concentrates in plasma, stored for up to 7 days. The…
The primary objective for this study is to evaluate the cerebrovascular reactivity of HCHWA-D patients:1. To compare the (autoregulatory) function of small brain vessels in HCHWA-D patients with matched controls using the cerebrovascular reactivity…
The main object is to evaluate the validity of a diagnostic screening package for bleeding tendency consisting of point-of-care devices when compared with the gold standard for bleeding tendency diagnosis.Other objects which will be investigated are…
The general aim of this study is to implement validated markers for CAA in asymptomatic individuals with CMBs, to investigate whether presence of CMBs signifies early CAA.
The primary aim of this study is to evaluate the effects of a structured, progressive task-oriented fitness training program applied in a group of 8 to 10 patients on perceived outcome of mobility after stroke when compared to individually-tailored…
The purpose of this study is to gain insight into the effects of auditory pacing on the stability and flexibility of hemiplegic gait coordination. It will be examined how auditory pacing can be best administered to improve the quality of hemiplegic…
The overall aim of this study is to investigate the pathophysiology of ICH by investigating intracerebral hemorrhage in HCHWA-D patients. By investigating triggers for ICH, hematoma expansion, recurrence rate and outcome in HCHWA-D related ICH we…
Primary Objective: 1) To charaterize microbleeds and microinfarcts at 7T, and compare their prevalence in people with and without diabetes, with or without cognitive impairmentSecondary Objective(s): 2) To assess the relevance of the lesions in the…
Primary Objective: 1) To compare the prevalence en number of microbleeds at 7T between older people with and without DM2, and to relate the lesions to cognitive performanceSecondary Objective(s): 1) To characterize cerebral microinfarcts at 7T and…
Primary aim: Examine whether and to what extent fatigue and quality of life of patients with SAH improve after participating in RE-SAB.Secundary aims: (1) Examine whether and to what extent physical activity level, physical fitness, coping style,…
The objective of this study is to investigate the effect of virtual reality training, given between 2 weeks and 6 months after stroke, on participation and subjective physical functioning in independently living patients .Primary research question:…
In oral FXa inhibitor-treated patients with acute intracranial bleeding, the objectives of this study are as follows:Primary Efficacy Objective:• To evaluate the effect of andexanet versus usual care on the rate of effective hemostasis.Secondary…
The objective of this study is twofold. The first objective is to study the effectiveness of implicit motor learning on walking speed in clients after stroke in daily practice. The second objective is to determine the technology acceptance,…
To investigate longitudinal changes in VR in patients with subjective cognitive impairment (SCI), mild cognitive impairment (MCI) and AD dementia compared with controls. To investigate whether VR predicts progression of disease severity (cognitive…
In oral FXa inhibitor-treated patients with acute intracerebral bleeding, the objectives of this study are as follows:Primary Efficacy Objective:To evaluate the effect of andexanet versus usual care on the rate of effective hemostasis.Secondary…
To compare the (cost-)effectiveness of early surgical hematoma evacuation versus a conservative treatment in elderly patients with a traumatic ASDH.
Primary objective: describe the longitudinal changes of Aβ38, Aβ40, Aβ42, and Aβ43 concentrations in CSF of patients with CAA, AD, and healthy control cases and estimate the differences in change between those groups.1. Explorative study to…
The effects of DPA compared to STOPP-START approach (SSA) prescribing on adverse drug reactions, medical complications, hospital readmission, quality of life in hospitalized geriatric patients with sarcopenia
This study has been transitioned to CTIS with ID 2024-511679-14-00 check the CTIS register for the current data. Our primary objective is to evaluate whether aSAH patients treated with therapeutic dose nadroparine have a lower 30-days mortality rate…
Objective: 1. To determine whether vascular reactivity is lowered in memory clinic patients with mixed and pure AD pathology. 2. To define whether vascular reactivity upon visual activation is associated with CAA or with other small vessel disease (…