399 results
Primary Objective: To determine the effectiveness of a comprehensive lifestyle intervention program aimed at reducing the risk of recurrent cardiovascular events in patients who have suffered an acute coronary syndrome.Secondary Objective:…
The primary objective of this study is to examine the effectiveness of the serious game called HealSeeker for improving time management, planning and organisation and social behaviour skills of children with ADHD. The secondary objective of this…
1. To reduce the time required for pre-exposure rabies vaccination of military personnel2. To reduce costs of pre-exposure rabies vaccination of military personnel 3. To obtain a non-inferior immune response to a shortened, low-dosed scheme compared…
To evaluate the effectiveness, cost-effectiveness and quality of life of Flaminal® versus Flammazine® in the treatment of superficial and deep partial thickness burns.
The objective of this study is to evaluate the effect of cabozantinib compared with everolimus on progression-free survival (PFS) and overall survival (OS) in subjects with advanced renal cell cancer that has progressed after prior VEGFR tyrosine…
The aim of this study is to determine whether the presence and the extent of periodontitis are independently related to the presence and extent of coronary calcification.To determine if periodontal treatment has an positive effect on the…
1. Overall survival (primary efficacy endpoint)2a. Efficacy: progression-free survival (PFS), overall response rate (ORR = CR + PR), and a clincal benefit rate (CBR) will be evaluated as CR + PR + SD for at least 3 months.2b. Safety: adverse events…
To externally validate the accuracy of a host-response based diagnostics for differentiating between bacterial and viral etiology in pediatric patients aged 2 to 60 months with LRTI or FWS.
The primary objective of this study is:• To evaluate the non-inferiority of switching to a TAF Containing STR relative to maintaining TDF Containing Regimens in Virologically Suppressed HIV-1 positive subjects as determined by having HIV 1 RNA * 50…
Primary Objective is to evaluate the long-term safety of sirukumab in subjects with RA who are refractory to DMARDs or anti-TNF* agents.The secondary objectives are to observe the following long-term effects of sirukumab in subjects with RA who are…
- To investigate the biochemical response of ITF2984, defined as a reduction in (random) GH < 1.0 mcg/l and/or normalization of IGF-1.- To investigate the biochemical response of ITF2984, defined as a reduction of GH to no more than 2.5 mcg/l…
To investigate the short-term and long-term effects of a 12-week motor skills intervention, including behavioural motivation techniques, on motor skills, physical activity, perceived motor competence and global self-worth in children with DCD.
The primary objective of the present study is to demonstrate that maintaining sinus rhythm after ECV for persistent AF in patients with severe chronic heart failure and reduced ejection fraction reduces NT-proBNP levels.
The primary objective is to investigate the effect of training on a neurofeedback task targeting the DLPFC, on the frontostriatal network. As a secondary objective, we investigate whether such training changes mental effort.
1. To explore the validity and usefulness of Bone Microindentation Technique (BMT) in the assessment of bone quality in patients with osteoporosis and a spectre of bone diseases characterised with (localised) increased bone turnover. 2. To study the…
The primary objective of the study is to assess the safety and tolerability of long-term open-label CP-690,550 therapy in subjects with CD.Secondary objectives are to evaluate the effect of CP-690,550 maintenance therapy on clinical remission and on…
This study investigates the optimal intraoperative treatment algorithm to lower glucose in patients with diabetes mellitus type 2 undergoing non-cardiac surgery, comparing intraoperative glucose-insulin-potassium infusion, insulin bolus regimen and…
In the current study, we want to demonstrate Rienso uptake in the vessel wall in patients with cardiovascular disease and relate the uptake of Rienso to endothelial permeability.
The primary objective of the proposed study is to examine the neural substrate of cognitive and social-emotional apathy in patients with schizophrenia. Secondary, we intend to explore the concentration of brain metabolites and structural differences…
-To determine the feasibility of detection of synovitis by photoacoustic imaging using three discrete wavelengths of pulsed light as an early indicator of the presence of RA.-To correlate the photoacoustic markers that are indicative for…