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Chronic Cerebrospinal Venous Insufficiency and Multiple Sclerosis: An age and sex-matched controlled Study.

The main point of this study is to detect in a controlled fashion if there is a relationship between CCSVI and MS. We focus on 5 parameters indicative of CCSVI: 1-reflux in the internal jugular vein (IJV) or in the vertebral vein (VV), or both with…

A 24-week, multicenter, international, randomized (1:1), parallel-group, open-label, comparative study of insulin glargine versus liraglutide in insulin-naïve patients with Type 2 diabetes treated with oral agents and not adequately controlled, followed by a 24-week extension period with insulin glargine for patients not adequately controlled with liraglutide

The primary objective of this study is to demonstrate the superiority of insulin glargine over liraglutide in termsof percentage of patients reaching a HbA1c < 7% at the end of the comparative period in Type 2 diabetic patientsfailing…

A prospective patient registry for bonegraft substitutes in spinal fusion

To identify the patient profile for Actifuse and for other grafting products used to achieve bone fusion.

Genetic Susceptibility to Papilloma-induced Voice Disturbance

To discover human genes which are likely to confer susceptibility for recurrent respiratory papillomatosis

The correlation between culture of the nasopharyngeal swab, the nose swab, swab from a handkerchief and a handkerchief directly in children with an upper respiratory tract infection

The objective is determine the correlation between the outcome of the cultures of the nasopharyngeal swab, the nose swab, the swab from a handkerchief and the handkerchief.

Effect of biphosphonates on teleangiectasia in irradiated breast cancer patients

To determine the effects of biphosphonates on radiation induced microvascular damage in the skin of breast cancer patients by comparing skin biopsies taken prior to and 4 months after treatment with a biphosphonate.

The Role of the Intestinal Barrier Function in Liver Cirrhosis

Understanding the pathophysiological mechanisms that play a role in liver cirrhosis and its complications. For that aim, we want to study the functional and morphological intestinal epithelial barrier and microbiota of both small and large intestine…

Brown Adipose Tissue Activity in Caucasians and South Asians

Main objective: 1) To investigate whether BAT activity differs between South Asians and Caucasians.Secondary objectives: 1) To investigate whether sympatic stimulation of BAT differs between South Asians and Caucasians2) To investigate the…

Influence of ryanodyne receptor 1 mutations on pulmonary arterial pressure and ventilation during isocapnic hypoxia

W want to investigate the influence of a mutaion in the MH allel on the HPV and the normal reaction of MH patients to hypoxia

Effects of Human Unacylated Ghrelin on Insulin Sensitivity during Euglycemic-Hyperinsulinemic- Clamp in Patients with Type 2 Diabetes Mellitus

One of the he questions that remains to be answered to further elucidate the mechanism of action is whether ot not UAG improves insulin sensitivity during a euglycemis-hyperinsulinemic clampThis study aims to clarify the effects of the continuous…

QEEG measurements to help identify developmental disorders in children.

The main aim of this research is to search for sensitive and specific QEEG markers to differentiate between children with a developmental disorder, in this case ADHD and ASD, and a control group and to differentiate between these two developmental…

An open-label phase 2A study to investigate drug-drug interactions between AT1001 (migalastat hydrochloride) and agalsidase in subjects with Fabry disease.

The primary objectives of this study are: * To characterize the effects of 150 mg and 450 mg of AT1001 administered 2 hours before administration of agalsidase on the safety and plasma pharmacokinetics of agalsidase in subjects with Fabry Disease*…

Clinical evaluation of Remote monitoring with dirEct Alerts* to reduCe Time from event to clinical decision

St. Jude Medical developed the Merlin.net* Patient Care Network (Merlin.net* PCN) to augment or replace routine scheduled in-clinic visits. This investigation is designed with the hypothesis that detection of events (system integrity and diagnostic…

Gadobutrol (Gadovist®) versus gadofosveset-trisodium (Vasovist®) in MR venography of the peripheral venous vasculature in deep vein thrombosis: is their a need for blood pool contrast agents?

Primary objectives:1. To determine image quality and diagnostic accuracy of CE-MRV using a new, optimized high resolution 3D T1 weighted volume interpolated gradient echo sequence with fat suppression (THRIVE) with both a blood pool and a…

Skeletal muscle characterization in frail elderly

To fully characterize skeletal muscle strength and endurance, phenotype and muscle fiber type-specific satellite cell content in frail elderly as compared to those elderly that do not classify as frail according to clinical criteria.

The effect of a preoperative lifestyle intervention in patients with acquired risk factors on perioperative glucose control and hemodynamics

The primary objective of this study is to investigate whether skeletal muscle glucose metabolism, perioperative glucose control and hemodynamics are affected by increasing physical activity in the weeks preceding surgery in patients identified with…

Construction of intraoperative pressure-volume loops using transesophageal echocardiography and noninvasive beat-to-beat continuous finger blood pressure monitoring

Is it possible to reconstruct intraoperative left ventricular end-systolic pressure-volume relations from a combination of non-invasive finger arterial blood pressure measurements and transoesophageal echocardiography in patients undergoing surgery?

INTERVENTIONAL MANAGEMENT OF STROKE TRIAL CLINICAL PROTOCOL - IMS III
A phase III, randomized, multi-center, open label, 900 subject clinical trial that will examine whether a combined intravenous (IV) and intra-arterial (IA) approach to recanalization is superior to standard IV rt-PA (Activase®/Actilyse®) alone when initiated within three hours of acute ischemic stroke onset.

The primary objective of the trial is to determine if ischemic stroke subjects with a baseline NIH Stroke Scale Score (NIHSSS] >= 10 (8-9 with positive CTA) treated with recombinant tissue plasminogen activator (rt-PA; [Alteplase recombinant…

Long term prospective observational cohort study of the safety and efficacy of golimumab in the daily clinical practice of rheumatoid arthritis with emphasis on the lipid profile

To determinate the efficacy and safety of golimumab in rheumatoid arthritis patients in daily clinical practice during 48 months. In addition, the effect of treatment with golimumab on the lipid profile will be monitored during this study.

A Multicenter, Multinational, Longitudinal Clinical Assessment Study of Subjects with Mucopolysaccharidosis IVA (Morquio Syndrome).

The objective of the study is to quantify endurance and respiratory function in subjects with MPS IV A and to better characterize the spectrum of symptoms and biochemical abnormalities in MPS IV A disease over time.