49 results
To evaluate the efficacy and safety of nilotinib in spondyloarthritis
The primary objectives are:- To evaluate clinical remission for the 2 subcutaneous (SC) maintenance regimens of ustekinumab in subjects with moderately to severely active Crohn*s disease induced into clinical response with ustekinumab in the…
To study the effect of a nerve block of the infrapatellar nerve with local infiltration with lidocaine or saline on chronic anterior knee pain after tibial nailing.Secondairy objectives:- to measure knee pain on a VAS for eight different activities…
Aim of the studyTo study the effectiveness and toxicity of dexamethasone to prevent the occurrence of a pain flare after short schedule radiotherapy for painful bone metastases and to define the optimal schedule of dosing.Research questions:1. What…
Primary Objective:• To determine the safety and feasibility of intracoronary allogeneic, immuno-selected, bone marrow-derived Stro3 MPC delivery in the treatment of subjects with STEMI undergoing PCI of the LAD coronary artery.Secondary Objectives…
Primary Objective: - To confirm the effect of dexamethasone on clinical outcome in patients admitted with CAP.Secondary Objectives: - To study what patients admitted with CAP benefit most from dexamethasone therapy. Predefined subgroup analysis…
1. To investigate the efficacy of Cogmed working memory training in reducing behavioral symptoms in children with neuropsychiatric disorders and borderline intellectual functioning.2. To investigate whether WM training improves neurocognitive…
The goal of this study is to positively influence quality of life in patients with hypothyroidism by giving them back control in their treatment. We also want to see what the placebo effect will be. And at last we want to check if patients have the…
To study in clinically stable COPD patients with muscle atrophy eligible for out-patient pulmonary rehabilitation:1.The short-term effects of 4 months exercise training including nutritional supplementation versus exercise training alone on physical…
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Primary objective: To identify the neural mechanisms via which testosterone modulates social decision-making. Secondary objectives: - To provide an extension of observed behavioral effects of testosterone on decision-making, specifically to examine…
Cost effectiveness of augmented cognitive behavioural therapy for post stroke depression and anxiety
Our main objective is to investigate whether an augmented CBT leads to the reduction of depression and anxiety symptoms in stroke patients. We will compare the outcomes of this experimental treatment with a control intervention (i.e., computerized…
The primary objective of this study is to evaluate the effect of dalcetrapib on HDL-C levels after 4 weeks of treatment whentreatment is initiated within 1 week after an ACS. The secondary objectives of this study are:- To compare the effect of…
The present study is aimed at investigating cognitive underpinnings of depression, by focusing on working memory abilities in both depressed and non-depressed individuals. These findings will be employed to design and test a therapeutic intervention…
PRM-151 is being developed for potential therapeutic use to prevent, treat and reduce fibrosis. This study will provide an assessment of the safety, tolerability, pharmacokinetics and pharmacodynamics of PRM-151 after administration of ascending…
Primary Objective: - Determine the effectiveness of a treatment with pulsed electromagnetic field therapy in patients with medial tibial stress syndrome (MTSS).Secondary Objective(s): - Determine the feasibility of the study design.- Determine the…
The primary objective of this study is to assess the safety and efficacy of voclosporin as therapy in subjects with active noninfectious uveitis involving the intermediate and/or posterior segments of the eye (i.e., anterior + intermediate-,…
Assessing the effectiveness and safety of parecoxib compared to placebo in pain relief children undergoing scoliosis surgery
The primary objective of this study is to compare overall survival (OS) in patients with metastatic colorectal carcinoma (CRC) when treated with FOLFIRI in combination with placebo versus FOLFIRI in combination with ramucirumab DP.Secondary…
Objective: To investigate whether acetaminophen is effective in treating self-reported sleep problems.